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Rich

@richcolepsych

Trainee Psychiatrist, Neurorehab RMO, PhD Student: TBI & Autism (@ReSpectLabKCL). Interested in Interoception, Computational Psychiatry, Alexithymia, FND, Embodiment. Sonic Queer.

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15.11.2024
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Latest posts by Rich @richcolepsych

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British Neuropsychiatry Association founded in 1987. Academic & professional body for practitioners & professionals allied to medicine at the interface of the clinical & cognitive neurosciences, & psychiatry

2026 British Neuropsychiatry Association Conference. Registration is open.

Memory & identity, brain injury, epilepsy, functional cognitive disorder, evolving forensic risk, neurostimulation

πŸ“ London | πŸ—“ 12–13 March 2026
🀝 Joint meeting with DoN

Programme and registrationπŸ‘‰ bnpa.org.uk/agm/

08.01.2026 13:34 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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Role of Serotonin in Schizophrenia and Association With Negative Symptoms This case-control study investigates the association of serotonin release with negative symptom severity in schizophrenia and if serotonin release is altered in vivo.

First paper to look at 5-HT release in vivo in schizophrenia, suggesting increased release (5-HT2A receptor availability not altered) in the frontal cortex, correlating with worse motivational symptoms, potentially by devaluing immediate reward shorturl.at/8Tfru

02.01.2026 08:18 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

@wiringthebrain.bsky.social 🫑

16.12.2025 14:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Beautiful takedown of the autism-microbiome hypothesis by Kevin Mitchell et al - Built on β€œpseudo-triangulation”: weak observational, mouse & clinical studies made to look convergent.

βœ…B

Autism β†’ behavioural/dietary differences β†’ microbiome variation, not the reverse

www.cell.com/neuron/fullt...

16.12.2025 14:23 πŸ‘ 10 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0
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Our June members' newsletter has just been sent out.

It has the latest in neuropsychiatry news and debates from the academic literature, media, and conference circuit.

Not a member? You can sign here:
bnpa.org.uk/membership/

02.06.2025 06:44 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

...and this capacity for shared agency required 1) self-reflection to consider oneself part of a group and 2) self-regulation & motivation to maintain group membership (a positive social identity) --> conformity and loyalty --> group membership --> survival

21.05.2025 08:02 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Loved this talk by Leon Li at the Royal Society on how social identity may have evolved as part of our human capacity & motivation for shared agency; putting β€œwe” over β€œme” - with the original form of social identity not being race/class, but moral identity as a cooperative group member....

21.05.2025 08:02 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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🧠 Help Us Understand Pain Perception in FND! 🧠

Looking for volunteers with & without #FND for a study in London @kingsioppn.bsky.social. Single lab visit testing pain perception with electrical stimulation.

Interested? Please message me: Livia.Asan@kcl.ac.uk βœ‰οΈ

Thanks for sharing!

07.03.2025 14:13 πŸ‘ 12 πŸ” 9 πŸ’¬ 2 πŸ“Œ 3

So interesting πŸ™

20.02.2025 10:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

ADM levels mediated up to 16.3% of the effect of loneliness on mortality, showing its importance in stress-related disease mechanisms

20.02.2025 10:32 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

ADM (Adrenomedullin) and ASGR1 (Asialoglycoprotein Receptor 1) showed the strongest causal evidence using colocalization analysis.

ADM levels correlated with reduced grey matter in the insula and caudate, brain regions involved in social and emotional processing…

20.02.2025 10:32 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Powerful study - used Mendelian Randomisation to show loneliness causally increased 5 proteins widely linked to various inflammatory and metabolic blood biomarkers but also brain regions involved in interoception, emotion, and social processes www.nature.com/articles/s41...

20.02.2025 10:32 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Our 2025 annual conference is happening in London, March 13-14.

Neuropsychiatry of sleep, FND treatment, impulsive control disorders, neuropsychiatry of TBI and much more.

Sign up, it'll be great to see you there
bnpa.org.uk/agm/

10.01.2025 13:14 πŸ‘ 3 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1

Interesting findings from this Phase 3 RCT of MDMA-assisted therapy for PTSD: Participants w/ higher baseline alexithymia saw the greatest PTSD symptom reduction, & the MDMA group saw a significant decrease in TAS-20 (DDF, DIF) scores. n.b. blinding challenges!

pmc.ncbi.nlm.nih.gov/articles/PMC...

21.01.2025 10:34 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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a woman is sitting at a table with her arms outstretched and the words `` guilty as charged '' . ALT: a woman is sitting at a table with her arms outstretched and the words `` guilty as charged '' .
17.01.2025 15:43 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Body and self: a dialogue between philosophy and neuroscience Join us for the next BRNet seminar with Ana Tajadura-JimΓ©nez and Adrian Alsmith.

🚨 Save the Date! 🚨

Join the next #BRNet Seminar:
πŸ’­ Body and Self: A Dialogue Between Philosophy and Neuroscience with @anatajadura.bsky.social & Adrian Alsmith.
πŸ“… Jan 17, 2025
πŸ“ Online
🎟️ Reserve your spot today: shorturl.at/nl3Ur
#Body #Philosophy #Neuroscience #Research

04.12.2024 10:28 πŸ‘ 21 πŸ” 13 πŸ’¬ 2 πŸ“Œ 3
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Psychiatric Comorbidities in Persons With Epilepsy Compared With Persons Without Epilepsy This systematic review and analysis examines the prevalence of 20 psychiatric disorders in persons with epilepsy compared with persons without epilepsy.

🚨 New meta-analysis highlights psychiatric diagnoses in persons with epilepsy (565,443 PWE vs. 13,434,208 controls)

1️⃣ Autism Spectrum Disorder: OR 10.67
2️⃣ Psychotic Disorder: OR 3.98
3️⃣ ADHD: OR 3.93
4️⃣ Schizophrenia: OR 3.72
5️⃣ Bipolar Disorder: OR 3.12

jamanetwork.com/journals/jam...

14.01.2025 09:22 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Matthias Michel, Jorge Morales, Ned Block & Hakwan Lau, Aphantasia as imagery blindsight - PhilArchive

Aphantasia as β€œBlindsight for the Mind’s Eye” – a fantastic letter presenting evidence (e.g., mental rotation tasks, forced choice tasks) that aphantasics may have nonconscious visual representations, not a true absence of imagery πŸ’­πŸ‘οΈπŸͺ¬πŸ§ 

Via @jorge-morales.bsky.social

philarchive.org/rec/MICAAI-5

19.12.2024 09:13 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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I (masochistically) enjoyed getting my head (almost) around Body as First Teacher on the Visceral Afferent Training Hypothesis – how the body’s rhythms (e.g. heartbeats) train the developing brain, shaping its architecture & building predictive models foundational for cognition

tinyurl.com/572pze6k

17.12.2024 11:08 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Why inflammatory reductionism is a threat to psychiatry (and the rest of medicine) Thomas Pollak explores the emergence of a new worldview which attempts to explain all manner of ills as the result of inflammation or immune dysfunction. H

Brilliant critique by Thomas Pollak on the rise of inflammation as a monocausal/catch-all explanation for complex conditions: "Inflammation has become the go-to explanatory model for those disillusioned by ambiguity and complexity" A must-read ❀️ academic.oup.com/brain/advanc...

28.11.2024 10:06 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Reconstructing dopamine’s link to reward The field is grappling with whether to modify the long-standing theory of reward prediction errorβ€”or abandon it entirely.

Enjoyed this article challenging the singular and classic reward prediction error role of dopamine www.thetransmitter.org/dopamine/rec...

20.11.2024 13:53 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0