Thomas Pradeu's Avatar

Thomas Pradeu

@pradeu

CNRS Research Director, Philosophy of Science and Theoretical Biology. Works on Immunology, cancer, and microbiome. CNRS & University of Bordeaux, France.

4,351
Followers
706
Following
11
Posts
12.10.2023
Joined
Posts Following

Latest posts by Thomas Pradeu @pradeu

Figure showing an overview of VEXAS syndrome. The clinical phenotype is expanding and the pathobiology of some manifestations have been elucidated. VEXAS=vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic.

Figure showing an overview of VEXAS syndrome. The clinical phenotype is expanding and the pathobiology of some manifestations have been elucidated. VEXAS=vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic.

VEXAS syndrome is a newly discovered multisystemic disease affecting most organs.

A Review provides a comprehensive overview of VEXAS syndrome, including the disease's discovery, diagnosis, and treatment: spkl.io/63321AvBXS

01.03.2026 14:33 πŸ‘ 14 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

Hi everyone, I am preparing a lecture and was thinking of the milestone papers in the field of bacterial immunity.

I was curious which ones would you include ?

Thanks!

26.02.2026 07:50 πŸ‘ 6 πŸ” 7 πŸ’¬ 2 πŸ“Œ 0
Master Zoom Q&A Meeting – philinbiomed We are organizing two informal online meetings via Zoom, during which we will provide further information about the PhilInBIoMed master program and answer any questions you may have.

Reminder: Master Philosophy in Biology and Medicine – Zoom Q&A

We are hosting our second online meeting to share details about the PhilInBioMed Master program on March 3, 11am (CET).

More information here: philinbiomed.cnrs.fr/master-zoom-...

26.02.2026 16:59 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Report on PhiloNeuro kick-off Conference – philinbiomed Behavioral models, neural representation, cognitive functions and dysfunctions, cellular memory, even NMDARs. Subjects typical of any neuroscience conference, but examined through the lens of philosophy: this is what the attendees of the Impact of Philosophical Thinking on Today’s Neuroscience meeting at the Bordeaux Neurocampus were treated to this past 24th and 25th of November. The first conference of its kind to be held in France, the meeting brought together international neuroscientists and philosophers who approach neuroscientific questions through philosophical perspectives, with researchers who apply scientometric approaches to evaluating the extent and nature of cooperation between the two disciplines. The objective of the conference was to launch a new interdisciplinary research project which itself unites Bordeaux-based neuroscientists (Nora Abrous, Serge Ahmed, Thomas Boraud, and Aline Desmedt) with Bordeaux-based philosophers of science (CΓ©dric Brun and Thomas Pradeu) in order to investigate, with the help of neuroscience and philosophy post-doc Christopher Stevens, the influence philosophical thinking has exercised and continues to exercise within the brain sciences.

Last November, we held a conference here at @neurobordeaux.bsky.social to kick off the new Impact of philosophical thinking in today's neuroscience post-doc project I'm now working on with @philinbiomed.bsky.social. Keynote speakers were John Bickle & Paul Thagard. My report here:
#PhilSky

13.01.2026 17:14 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Master β€œPhilosophy in Biology and Medicine” – philinbiomed The International Master of Philosophy in Biology and Medicine in Bordeaux offers a unique philosophical approach to the life sciences that combines the development of conceptual tools and direct engagement with scientific theory and practice.

Applications open: Bordeaux Master in Philosophy in Biology and Medicine (deadline March 27)

The international program is targeted at philosophy and science students interested in integrating both approaches in fields like cancer,immunology,neuroscience, aging.
Info: www.philinbiomed.org/teaching

16.02.2026 10:59 πŸ‘ 8 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
Master Zoom Q&A Meeting – philinbiomed We are organizing two informal online meetings via Zoom, during which we will provide further information about the PhilInBIoMed master program and answer any questions you may have.

Master Philosophy in Biology and Medicine – Zoom Q&A

We are hosting two informal online meetings to share details about the PhilInBioMed Master program and answer questions on Feb 16, 5pm (CET) & Mar 3, 11am (CET).

More information can be found here: philinbiomed.cnrs.fr/master-zoom-...

16.02.2026 11:05 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Bordeaux Summer School - Philosophy in biology and medicine

Bordeaux Summer School – Philosophy in Biology & Medicine (1–5 June 2026)

Join us in collaboratively exploring the conceptual foundations of scientific research at the crossroads of philosophy, biology and medicine!

Apply by March 15
More information: bss-philinbiomed.u-bordeaux.fr/en/

18.02.2026 09:55 πŸ‘ 8 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
Post image

This Thursday! Online PhilInBioMed Talk by David B. Allison, Professor, Baylor College of Medicine, USA, #nutrition expert: "Truth, #Trust, Trustworthiness, and #Transparency: Foundations for Rigorous Science and Communication"
February 26th, 5pm French time: philinbiomed.cnrs.fr/event/david-...

23.02.2026 08:26 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Preview
The Importance of Biological Theory - Biological Theory Biological Theory -

I am happy to share this article, entitled "The importance of Biological Theory". It is my inaugural editorial as the new Editor-in-Chief of @biologicaltheory.bsky.social . In these complex and challenging times, theory is more important now than ever. Enjoy!

doi.org/10.1007/s137...

30.01.2026 13:40 πŸ‘ 87 πŸ” 42 πŸ’¬ 1 πŸ“Œ 2

⏰ Next week!

@aliboyle.bsky.social
@thebsps.bsky.social
@vanessaseifert.bsky.social

#PhilSci #Philosophy #Popper

16.02.2026 11:52 πŸ‘ 21 πŸ” 11 πŸ’¬ 0 πŸ“Œ 1
SISB2026

Abstract submission is now OPEN for the 2026 Symposium on the Immune System of Bacteria!

sisb2026.rockefeller.edu
πŸ—“ May 5–7, 2026
πŸ“ Rockefeller University, New York City
⏰ Abstract deadline: March 16, 2026

Attendance will be capped, be sure to register early and secure your spot.

See you in NYC!

11.02.2026 14:05 πŸ‘ 22 πŸ” 13 πŸ’¬ 0 πŸ“Œ 2

The 2026 symposium on the immune system of bacteria, New York, May 5-7

A fantastic lineup of speakers, looking forward to seeing top unpublished discoveries on bacterial immunity

20.02.2026 08:56 πŸ‘ 10 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0

We'll be there with many lab members, sharing new stories, we'll be very happy to get feedback on :)

Really looking forward.

11.02.2026 17:18 πŸ‘ 15 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Post image

Deadline is approaching (Feb 9) to apply for a PI position at Institut Pasteur. Come join us and contribute to an amazing scientific environment!!!

19.01.2026 16:55 πŸ‘ 17 πŸ” 31 πŸ’¬ 1 πŸ“Œ 0
Post image

Join us in congratulating Philip J. Kranzusch (@kranzuschlab.bsky.social) of @danafarber.bsky.social and @harvardmed.bsky.social, winner of the 2026 NAS Award in Molecular Biology for his groundbreaking work advancing understanding of innate immunity! www.nasonline.org/award/nas-aw... #NASaward

22.01.2026 16:04 πŸ‘ 60 πŸ” 12 πŸ’¬ 4 πŸ“Œ 2
Preview
Postdoctoral position - Synthetic Biology / Bacterial Immunity - Research The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...

🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology andπŸ›‘οΈ Bacterial Immunity. Come do great science with us in the middle of Paris! πŸ‡«πŸ‡·πŸ₯ research.pasteur.fr/en/job/postd...

28.01.2026 11:19 πŸ‘ 74 πŸ” 81 πŸ’¬ 0 πŸ“Œ 2
Preview
The paradox of immune systems conservation between prokaryotes and eukaryotes - Nature Reviews Microbiology The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Arg...

The immune systems paradox

Some widespread prokaryotic immune systems are absent in eukaryotes, whereas relatively rare ones became central to eukaryotic innate immunity

@audeber.bsky.social & E. Koonin hypothesize the answer is #HGT

shareable link: rdcu.be/e2EmD

www.nature.com/articles/s41...

06.02.2026 10:22 πŸ‘ 43 πŸ” 18 πŸ’¬ 2 πŸ“Œ 1
Post image

Excellent @philinbiomed.bsky.social seminar by Richard Michod (U Arizona) today: Reorganization of fitness during evolutionary transitions in individuality. Video available here: philinbiomed.cnrs.fr/event/richar... #biology #philosophy #individual #fitness #evolution #multicellularity #volvox

29.01.2026 05:06 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Preview
Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1934 Can't sign in? Forgot your password?

Special issue on "The ecology and evolution of bacterial immune systems." @pradeu.bsky.social @philinbiomed.bsky.social and all the other philosophers interested in immunology, etc.

royalsocietypublishing.org/toc/rstb/202...

05.09.2025 14:25 πŸ‘ 20 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0
Post image

PPP2R1A mutations are linked to improved response to immunotherapy in ovarian clear cell carcinoma @nature.com
www.nature.com/articles/s41...

02.07.2025 20:21 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Preview
What we stand to lose when foreign students are seen as a threat International students enrich university communities and strengthen civic life. We must defend their place in global education.

International students enrich university communities and strengthen civic life. We must defend their place in global education. @nature.com @mchankseliani.bsky.social
www.nature.com/articles/d41...

02.07.2025 20:22 πŸ‘ 13 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
Post image

The Somatic Mosaicism across Human Tissues Network @nature.com @timcoorens.bsky.social
www.nature.com/articles/s41...

02.07.2025 20:27 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Preview
Functional amyloid proteins confer defence against predatory bacteria - Nature Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a mechanism th...

Functional amyloid proteins confer defense against predatory bacteria @nature.com @hannahledvina.bsky.social @aaronwhiteley.bsky.social
www.nature.com/articles/s41...

02.07.2025 20:29 πŸ‘ 7 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
Post image

The mutagenic forces shaping the genomes of lung cancer in never smokers @nature.com
www.nature.com/articles/s41...

02.07.2025 20:31 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Post image

Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukemia @sabaghassemi.bsky.social
www.nature.com/articles/s41...

02.07.2025 20:35 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Post image

Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity @cp-immunity.bsky.social
www.cell.com/immunity/ful...

30.06.2025 16:00 πŸ‘ 10 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
Preview
Advancing cancer research via comparative oncology Nature Reviews Cancer - Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular...

New paper out! rdcu.be/etKdN Experts in #cancer across the tree of life and philosophers of science teamed up to explore how comparative thinking can improve current approaches to cancer, including conceptually and therapeutically. #evolution #ecology #oncology #philosophy

30.06.2025 07:48 πŸ‘ 11 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

We are looking forward to an exciting week with great speakers, interesting discussions on Philosophy in Science and intriguing project work! (4/4)

03.06.2025 17:09 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Post image

James DiFrisco (Crick Institute, UK) on "Moving beyond conceptual analysis: conceptual methodology for philosophy 'in' science"

03.06.2025 17:05 πŸ‘ 4 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
Post image

Some impressions of the first day of the #PhilInBioMed at University of Bordeaux! (1/?)

Full program here: www.philinbiomed.org/event/bordea...

#BSS2025 #Philosophy #Biology #Medicine #SummerSchool

03.06.2025 16:58 πŸ‘ 6 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0