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Lisa Genzel (she/her)

@lgenzel

in love with memory and sleep research, puts rats, mice and humans into complex, mulit-trial tasks

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18.11.2024
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Latest posts by Lisa Genzel (she/her) @lgenzel

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Deconstruction of a memory engram reveals distinct ensembles recruited at learning - Nature Neuroscience Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

How does the brain build a memory?
A common assumption is that the neurons activated during an experience collectively form the memory engram.
In our new Nature Neuroscience paper (finally out!), we show that this is not the case.
www.nature.com/articles/s41...

11.03.2026 21:48 πŸ‘ 136 πŸ” 51 πŸ’¬ 11 πŸ“Œ 1
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Every time you experience something new, your brain faces a decision: Should it update an existing memory or create a new one?

In our new paper in @sfnjournals.bsky.social #JNeurosci, we isolate that exact decision, moment-by-moment during learning 🧡

06.03.2026 18:54 πŸ‘ 131 πŸ” 46 πŸ’¬ 3 πŸ“Œ 1
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Young PI Symposium 2026 Visit the post for more.

Today we present another of our amazing speakers: @anne-schreiter.bsky.social the executive director from @gso-forresearchers.bsky.social. She will give us an interactive workshop about Leadership and Team-building.

Register to our @fens.org Satellite πŸ‘‰ youngpisymposium2026.com

06.03.2026 10:33 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

The deadline for our young PI symposium was extended! Don't miss out on this opportunity to build your community and share strategies to navigate these uncertain times.

06.03.2026 10:36 πŸ‘ 7 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Human hippocampal theta–gamma coupling coordinates sequential planning during navigation

Impressive study from Dan Bush's Lab at UCL:

www.pnas.org/doi/10.1073/...

02.03.2026 16:52 πŸ‘ 78 πŸ” 26 πŸ’¬ 2 πŸ“Œ 1
MEEP – Heidelberg Summer School on Memory and Sleep Join our 4-day summer school on memory consolidation, neural replay, and sleep. May 31–June 3, 2026 in Heidelberg. For Master, PhD students & postdocs.

Registration open πŸŽ‰

MEEP – Heidelberg Summer School on Memory and Sleep

www.zi-mannheim.de/forschung/ab...

23.02.2026 09:09 πŸ‘ 19 πŸ” 18 πŸ’¬ 0 πŸ“Œ 1

Awesome new opportunity to join SWC if you are into human ephys.

13.02.2026 18:05 πŸ‘ 4 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Do you work or study in the fields of psychology, neuroscience, computer science, artificial intelligence, or philosophy?

What does the term 'representation' mean to you?

We invite you to participate in a brief survey on key conceptual questions across fields.

eu.surveymonkey.com/r/VX9GNXM

12.02.2026 13:39 πŸ‘ 66 πŸ” 60 πŸ’¬ 4 πŸ“Œ 3
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Building compositional tasks with shared neural subspaces Nature - The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.

Thrilled that my paper is out in the @nature.com. We explored how the brain builds complex tasks by compositionally combining simpler sub-task representations. The brain flexibly performs multiple tasks by dynamically reusing neural subspaces for sensory inputs and motor actions

rdcu.be/eRVUk

11.02.2026 22:40 πŸ‘ 131 πŸ” 47 πŸ’¬ 4 πŸ“Œ 1
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New paper alert! 🚨

We found that the brain's compass is remarkably stable at two scales

1️⃣ the system maintains its internal organization for weeks
2️⃣ It "remembers" its orientation for weeks, even after a single visit

This may be key to how the brain aligns its other maps.

Paper: rdcu.be/e3waP

11.02.2026 17:52 πŸ‘ 199 πŸ” 69 πŸ’¬ 5 πŸ“Œ 7

Can we make brains β€œsmarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!

11.02.2026 11:36 πŸ‘ 58 πŸ” 20 πŸ’¬ 1 πŸ“Œ 6
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Why did consciousness evolve at all? A superb special issue of @royalsocietypublishing.org brings together experts across disciplines to explore the functions of consciousness and why it emerged in some species but not others. @tecumsehfitch.bsky.social royalsocietypublishing.org/rstb/issue/3...

08.02.2026 12:47 πŸ‘ 135 πŸ” 51 πŸ’¬ 6 πŸ“Œ 3
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"..hippocampal-prefrontal systems represent emotion concepts in a map-like way at multiple levels of abstraction.."

Map-like representations of emotion knowledge in hippocampal-prefrontal systems
by
@yumengma.bsky.social and @pkragel.bsky.social

www.nature.com/articles/s41...

09.02.2026 09:35 πŸ‘ 41 πŸ” 13 πŸ’¬ 0 πŸ“Œ 0

My lab is looking to recruit 1-2 paid summer interns to do wet lab work on learning in a unicellular organism (Stentor coeruleus). You can apply here:
forms.gle/b47WpSobjFjo...

05.02.2026 11:21 πŸ‘ 30 πŸ” 27 πŸ’¬ 1 πŸ“Œ 1
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Many people have no mental imagery. What’s going on in their brains? People with aphantasia are offering a window into consciousness.

Most people can call up pictures in their minds, visualizing the past & summoning images of the future. But for ~4% of us, such mental imagery is weak or absent. New edition of @nature.com has a nice introduction to how research on this phenomenon (aphantasia) opens up novel windows into the brain.πŸ§ͺ

04.02.2026 18:34 πŸ‘ 62 πŸ” 20 πŸ’¬ 0 πŸ“Œ 5

Infraslow modulation of theta synchrony in the hippocampus circuit during REM sleep https://www.biorxiv.org/content/10.64898/2026.01.30.702893v1

03.02.2026 03:16 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Attention-like regulation of theta sweeps in the brain's spatial navigation circuit https://www.biorxiv.org/content/10.64898/2026.01.27.702083v1

28.01.2026 10:16 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

This is totally wild. Remember the object they are attending to is presented egocentrically, but the allocentric theta sweeps follow it. The whole system is wired up to provide something like an "integrated attention reflex".

28.01.2026 10:28 πŸ‘ 36 πŸ” 5 πŸ’¬ 2 πŸ“Œ 0
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Deadline is almost here, have you applied? fenskavlinetwork.org/who-we-are/a...

24.01.2026 13:38 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Sequential coupling of sleep oscillations enables concept-neuron reactivation and supports information flow across the human hippocampal-cortical circuit https://www.biorxiv.org/content/10.64898/2026.01.15.699122v1

18.01.2026 08:15 πŸ‘ 10 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Tolman's Sunburst Maze 80 Years on: A Meta‐Analysis Reveals Poor Replicability and Little Evidence for Shortcutting In 1946, Tolman etΒ al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...

Can humans & animals really use internal maps to take shortcuts?

Tolman famously said yes - based largely on his Sunburst maze.

Our new review & meta-analysis suggests evidence is far weaker than you might think.
πŸ§΅πŸ‘‡ doi.org/10.1111/ejn....

@uofgpsychneuro.bsky.social @ejneuroscience.bsky.social

05.01.2026 19:52 πŸ‘ 135 πŸ” 57 πŸ’¬ 7 πŸ“Œ 11

Very happy for this @ejneuroscience.bsky.social editorial on the importance of diverse research animals in neuroscience. We make the case that embracing a plurality of model organisms enriches the field and accelerates both basic and translational research. onlinelibrary.wiley.com/doi/10.1111/...

06.01.2026 07:47 πŸ‘ 27 πŸ” 17 πŸ’¬ 2 πŸ“Œ 1
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What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

04.01.2026 06:17 πŸ‘ 130 πŸ” 50 πŸ’¬ 3 πŸ“Œ 2

Meta-learning is expressed through altered prefrontal cortical dynamics https://www.biorxiv.org/content/10.64898/2026.01.01.697272v1

02.01.2026 08:16 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Subspace communication in the hippocampal-retrosplenial axis https://www.biorxiv.org/content/10.64898/2025.12.31.697203v1

02.01.2026 08:16 πŸ‘ 9 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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❄️ A Year of #FENS: @fkne-scholars.bsky.social ❄️

🧠 #FKNE has continued throughout 2025 to champion excellence in European neuroscience by supporting researchers and strengthening scientific leadership across Europe

πŸ‘‰ Learn more about #FKNE here: buff.ly/2EWch1g

31.12.2025 11:00 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...

⚠️ New paper alert and what a way to end 2025! πŸŽ‰
Happy to share our story β€œSleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience.

Sleeping dragons 🦎 and functional ultrasound!
Read the full paper here: rdcu.be/eWJHb 1/8

29.12.2025 16:17 πŸ‘ 101 πŸ” 37 πŸ’¬ 3 πŸ“Œ 2

Deadline is approaching too fast!! Don’t miss it!

20.12.2025 10:42 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

It's an important conversation for society to have - that ethical trade-off that @micheleabasso.bsky.social describes and you point to.

As we have it, we need to acknowledge that without animal research, new treatments for neurodegenerative and psychiatric conditions will be blocked/stalled.

12.12.2025 14:21 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Share and apply!

10.12.2025 19:02 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0