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Nick Loman

@pathogenomenick

Public health (meta)genomics & bioinformatics, Prof @unibirmingham.bsky.social, Director @imibirmingham.bsky.social & @climb.ac.uk

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05.09.2023
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Latest posts by Nick Loman @pathogenomenick

"Russian flu," the pandemic that hit in 1977, bears an evolutionary signature of having emerged from a lab, perhaps as part of a failed vaccine effort. Covid, mpox, Ebola, and other influenza pandemics don't. Here's my story on a new way to trace the origins of pandemics. Gift link: nyti.ms/46N0W33

09.03.2026 17:26 πŸ‘ 112 πŸ” 48 πŸ’¬ 2 πŸ“Œ 3

indeed, Bluesky's inherent overall hostility to AI means that the AI enthusiasts still willing to hang out here are usually far smarter and more thoughtful than the absolute dribbling freakshow AI cultists who dominate Twitter/X

09.03.2026 17:26 πŸ‘ 844 πŸ” 88 πŸ’¬ 25 πŸ“Œ 1

Let me tell you something. Y’all are asking too many damn questions at every point of sale. I have to leave a comment, make a suggestion, donate to a charity, choose a method of payment three times and then multiple choice of ways to get a receipt.

Take the damn money and leave me alone.

09.03.2026 16:38 πŸ‘ 3888 πŸ” 458 πŸ’¬ 65 πŸ“Œ 132

I remain fascinated by people who are 100% all-in on using LLMs at their jobs (and telling everyone that they're doing it) and who appear to have never paused to consider "what value am I personally adding in here, at this point, and why do I think my employers won't eventually figure this out"

09.03.2026 16:43 πŸ‘ 342 πŸ” 59 πŸ’¬ 24 πŸ“Œ 4
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Today is the start of the 5th Analysing Microbial Genomic Data course at @unibirmingham.bsky.social #AMGDMar26 - in the last three years we’ve trained nearly 80 attendees from six countries and multiple UK universities

09.03.2026 09:54 πŸ‘ 22 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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Blocking mobile internet on smartphones improves sustained attention, mental health, and subjective well-being Abstract. Smartphones enable people to access the online world from anywhere at any time. Despite the benefits of this technology, there is growing concern

This is empirically backed btw, even just blocking internet on your phone improves mental health more than anti-depressants.

09.03.2026 09:12 πŸ‘ 22 πŸ” 10 πŸ’¬ 3 πŸ“Œ 0

It’s fantastic!

09.03.2026 08:06 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Audiobook cover of "Enshittification: Why Everything Suddenly Got Worse and What to Do About It" by Cory Doctorow

Audiobook cover of "Enshittification: Why Everything Suddenly Got Worse and What to Do About It" by Cory Doctorow

Just finished listening to the audiobook of @doctorow.pluralistic.net's "Enshittification", and *wow* what a book! It encapsulates so many things I've been feeling about the modern tech industry, but articulated so much better than I could. Highly recommend!!

09.03.2026 02:17 πŸ‘ 30 πŸ” 7 πŸ’¬ 3 πŸ“Œ 0
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New post, on whether I could get Claude Code to complete a data task that had taken me AGES a decade ago…

kucharski.substack.com/p/how-much-t...

08.03.2026 08:09 πŸ‘ 128 πŸ” 43 πŸ’¬ 5 πŸ“Œ 6

Has been pretty vindicating that the people on Twitter we used to argue with about COVID actually got their chance to run things and they each turned out to be every bit the incompetent fuckwit that we knew they’d be

07.03.2026 00:17 πŸ‘ 335 πŸ” 52 πŸ’¬ 1 πŸ“Œ 0
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Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data.

The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k...

Figure 1 shows they key result

06.03.2026 19:32 πŸ‘ 181 πŸ” 86 πŸ’¬ 6 πŸ“Œ 8
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Quit ChatGPT: right now! Your subscription is bankrolling authoritarianism | Rutger Bregman As a historian, I’ve studied the major consumer boycotts of history. We can take down ChatGPT and send a powerful signal to Silicon Valley, says author and historian Rutger Bregman

"The most effective consumer boycotts in history share two qualities: they are narrow and they are easy," writes @rutgerbregman.com

04.03.2026 14:44 πŸ‘ 2338 πŸ” 1162 πŸ’¬ 74 πŸ“Œ 105
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Data Centers: The Hidden Backbone of Our Modern World | The Stepchange Show From room-sized mainframes to gigawatt campuses, discover the physical infrastructure that powers our digital worldβ€”and how the AI revolution is transforming data centers.

Everyone is interested in data centers these days, so I recommend going back and listening to this long, in-depth podcast about the history of data centers. You will feel much more grounded and informed about current debates.

04.03.2026 20:03 πŸ‘ 86 πŸ” 31 πŸ’¬ 2 πŸ“Œ 1
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1908: the Lancet, one of the most respected scientific journals, calls for 18 age limit on reading in bed amidst a moral panic surrounding children becoming "addicted" to novels, which were "designed to keep kids hooked" and destroy their attention/mental health

03.03.2026 17:13 πŸ‘ 2407 πŸ” 866 πŸ’¬ 3 πŸ“Œ 151
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3 Ways To Turn Overwhelm Into A Productivity Tool, By A Psychologist We’ve been taught to immediately cut off from the feeling of being overwhelmed. The science, however, might suggest that it’s asking you to lean in.

3 Ways To Turn Overwhelm Into A Productivity Tool, By A Psychologist

04.03.2026 14:45 πŸ‘ 56 πŸ” 14 πŸ’¬ 23 πŸ“Œ 3
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New personal view article

The role of microbial genomics in delivering the UK’s national action plan for confronting antimicrobial resistance 2024–29

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #AMR #OpenAccess #OA

04.03.2026 12:35 πŸ‘ 20 πŸ” 18 πŸ’¬ 2 πŸ“Œ 0

Nature is healing!

04.03.2026 15:10 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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With Eugene Koonin, we propose a concept of β€œthe selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

03.03.2026 08:58 πŸ‘ 223 πŸ” 96 πŸ’¬ 5 πŸ“Œ 13
Headshot of Jeff Cole

Headshot of Jeff Cole

We were deeply saddened to learn of the death of Professor Jeff Cole, a long-standing member who held many positions in the Society. Jeff was elected an Honorary Member in 2011. You can read his full obituary here: microb.io/46xYzkz

03.03.2026 10:15 πŸ‘ 18 πŸ” 9 πŸ’¬ 2 πŸ“Œ 2
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Deacon can now run in the browser using WebAssembly. Sequence data never leaves your machine. It currently supports FASTA/Q filtering using indexes up to 1GB in size.

Demo: bede.im/deacon

03.03.2026 14:30 πŸ‘ 29 πŸ” 10 πŸ’¬ 1 πŸ“Œ 1
MicroGPT Visualized β€” Building a GPT from scratch β€” an interactive visual guide Building a GPT from scratch β€” an interactive visual guide

Step 1 is now available in MicroGPT Visualized

microgpt.jtauber.com

01.03.2026 04:36 πŸ‘ 51 πŸ” 8 πŸ’¬ 1 πŸ“Œ 1
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Release SeqKit v2.13.0 (10-year-old birthday version) Β· shenwei356/seqkit Changelog SeqKit is 10 years old! SeqKit v2.13.0 - 2026-02-28 seqkit: add support for reading and writing LZ4 compression format. new command: seqkit sample2: improved seqkit sample by @stahiga....

Can't wait to release a 10-year-old birthday version for SeqKit!

- 10 years
- 2 papers, 3500 citations
- 20 contributors
- 40 subcommands
- 880 commits
- 500 issues
- 685.5K Bioconda total downloads

Thank you all, dear contributors and users!
I'll keep maintaining it.

github.com/shenwei356/s...

27.02.2026 13:25 πŸ‘ 123 πŸ” 35 πŸ’¬ 6 πŸ“Œ 1
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Quite rare to see a chart that says quite so overtly that no one involved has the slightest clue what’s happening here

26.02.2026 09:15 πŸ‘ 3400 πŸ” 604 πŸ’¬ 221 πŸ“Œ 387

Oh, this Allister Heath Headline Generator is brilliant fun. Check out the results of my first test πŸ‘‡πŸ‘‡πŸ‘‡ #UTISky

26.02.2026 15:54 πŸ‘ 13 πŸ” 2 πŸ’¬ 5 πŸ“Œ 0
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How the β€˜confident authority’ of Google AI Overviews is putting public health at risk Experts say tool can give β€˜completely wrong’ medical advice which could put users at risk of serious harm

How the β€˜confident authority’ of Google AI Overviews is putting public health at risk www.theguardian.com/technology/n...

26.02.2026 21:02 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

I am deeply saddened by Jeff's passing. Jeff lived and breathed microbiology, and was still very much part of the microbiology community in @imibirmingham.bsky.social until a few weeks ago. He was supportive to students and staff and will be sorely missed by many, here in Birmingham and elsewhere

26.02.2026 12:25 πŸ‘ 23 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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It is with deep sadness that we share the passing of Professor Jeff Cole. An esteemed academic, Jeffs research on bacterial adaptation to oxygen and nitrosative stress made a lasting impact on the field. He mentored nearly 60 doctoral students, our thoughts are with his family, friends & colleagues

26.02.2026 10:27 πŸ‘ 10 πŸ” 7 πŸ’¬ 0 πŸ“Œ 3

What’s holding back clinical use of phage therapy in the UK?

Our workshop last year brought together international experts, biotech and regulators to find out

Meeting Report out now in Nature Microbiology with our take on the challenges and opportunities facing the UK phage therapy sector

14.02.2026 17:54 πŸ‘ 46 πŸ” 21 πŸ’¬ 1 πŸ“Œ 0

I was an Amstrad guy….

25.02.2026 20:42 πŸ‘ 2 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

Can safely way this is the craziest and coolest study I have led. We chart the evolution of sheeppox virus, finding it in the Eurasian steppe ~3700 years ago, and also in a LOT of parchment from medieval Europe (made from a range of animals skins!) #aDNA

25.02.2026 07:45 πŸ‘ 55 πŸ” 23 πŸ’¬ 5 πŸ“Œ 1