St Vincent's Healthcare Group Libraries (@svhglibraries)

Agreement across different measurements for internal carotid artery stenosis in patients with TIA or stroke in the CONVINCE trial - PubMed Question Advances in CT angiography acquisition and semi-automated software introduce new methods for stenosis assessment. How do these methods compare to the traditional minimal diameter-based NASCET approach? Findings Stenosis classification varies substantially across methods, with both systemati …

pubmed.ncbi.nlm.nih.gov/40753328/

09.03.2026 12:47 👍 0 🔁 0 💬 0 📌 0

Cutting waste in cancer care: acceptability of novel waste-reduction strategies in oral therapies amongst Irish oncology stakeholders - PubMed Patients are open to split-fill prescribing, which could potentially decrease drug wastage.

pubmed.ncbi.nlm.nih.gov/41240258/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial - PubMed The Swedish Research Council (Vetenskapsrådet), the Swedish Heart-Lung Foundation, the Stig and Ragna Gorthon Foundation, the Knutsson Foundation, the Laerdal Foundation, the Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research, the Bundy Academy at Lund University, Regional Re …

pubmed.ncbi.nlm.nih.gov/41391459/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

KEYLYNK-009: Pembrolizumab plus Olaparib in Locally Recurrent Inoperable or Metastatic Triple-Negative Breast Cancer after Clinical Benefit from First-Line Pembrolizumab plus Chemotherapy - PubMed Although the primary endpoint was not met, postinduction pembrolizumab plus olaparib therapy resulted in similar PFS and OS compared with pembrolizumab plus chemotherapy in this setting. The positive trend for PFS and OS in participants with tBRCAm suggests a potential nonchemotherapy strategy for m …

pubmed.ncbi.nlm.nih.gov/41405563/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signaling - PubMed Together, our findings suggest that the TWEAK/NF-κB/STAT3 axis represents an attractive target to tune inflammatory stroma/monocyte crosstalk.

pubmed.ncbi.nlm.nih.gov/41765035/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Perioperative approaches for patients with biliary tract cancer - PubMed Biliary tract cancers, encompassing intrahepatic, perihilar and distal cholangiocarcinoma and gallbladder cancer, are a heterogeneous group of highly aggressive malignancies. Most patients have unresectable disease at first presentation, and even those who undergo surgery are likely to have disease …

pubmed.ncbi.nlm.nih.gov/41776242/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Evaluation and Management of Thyroid Nodules: A Joint Consensus Statement From the British Thyroid Association (BTA), British Association of Endocrine and Thyroid Surgeons (BAETS) and Collaborating Bodies - PubMed Evaluation and Management of Thyroid Nodules: A Joint Consensus Statement From the British Thyroid Association (BTA), British Association of Endocrine and Thyroid Surgeons (BAETS) and Collaborating Bodies

pubmed.ncbi.nlm.nih.gov/41784119/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Plasma exchange aids thyroidectomy in refractory amiodarone-induced thyrotoxicosis, despite variable biochemical responses - PubMed TPE may provide temporary biochemical improvement and clinical stabilisation in refractory AIT, facilitating safe progression to thyroidectomy. However, its biochemical effects can be inconsistent and transient, and complications such as coagulopathy must be anticipated. Our experience supports the …

pubmed.ncbi.nlm.nih.gov/41784295/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Clinical Practice Guideline on the Choice of First Antipsychotic Medicine for Females Experiencing a First-Episode of Psychosis - PubMed This is the first CPG addressing antipsychotic choice for females with FEP. By prioritizing critically important patient outcomes and lived experience, the guideline supports safer, sex-sensitive prescribing for females that may improve treatment acceptability, adherence, and equity in psychosis car …

pubmed.ncbi.nlm.nih.gov/41793755/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Minor non-fermenting Gram-negative bacilli in Europe, 2020-2024 (MINOFEu) - PubMed This study provides an updated overview of the diagnostic approaches and epidemiology of minor NFGNB across Europe, supporting future comparative analyses and improved diagnostic and antimicrobial strategies.

pubmed.ncbi.nlm.nih.gov/41794341/

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Papers authored/co-authored by staff/affiliates of SVHG @svuh.bsky.social

09.03.2026 12:47 👍 0 🔁 0 💬 1 📌 0

Bimekizumab demonstrated a favorable safety profile and high levels of efficacy with up to 2 years of treatment in patients with moderate to severe hidradenitis suppurativa: Pooled results from two phase 3 randomized, controlled trials and their open-label extension - PubMed Bimekizumab was well-tolerated up to 2 years; no new safety signals were identified with longer exposure. Bimekizumab provided deep, durable improvements in clinical and HRQoL outcomes.

pubmed.ncbi.nlm.nih.gov/41248770/

02.03.2026 12:32 👍 0 🔁 0 💬 0 📌 0

Navigating the ethical and regulatory landscape in surgical research: The Irish surgical research collaborative's guide - PubMed This ISRC and NSRSC guide provides a practical framework to support investigators in delivering high-quality, compliant, and patient-centred research within the Irish healthcare system.

pubmed.ncbi.nlm.nih.gov/41724645/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Advancing dermatologic patient decision aids: The need for standardized reporting and development practices - PubMed Advancing dermatologic patient decision aids: The need for standardized reporting and development practices

pubmed.ncbi.nlm.nih.gov/41725279/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Operating Together: Challenges and Solutions for Sustaining Impactful Global Health Partnerships From 18 years of the RCSI/COSECSA Surgical Training Collaboration - PubMed The RCSI/COSECSA collaboration program demonstrates that, over time, global health partnerships can play a transformational role in improving health outcomes in low-resource settings, while also benefitting high-income partners. Analysis of the development of the collaboration offers practical strat …

pubmed.ncbi.nlm.nih.gov/41725554/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Reply to: "Targeted Axillary Dissection Versus Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy: Why Staging Accuracy Matters," by Venkataraman, Janhavi et al - PubMed Reply to: "Targeted Axillary Dissection Versus Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy: Why Staging Accuracy Matters," by Venkataraman, Janhavi et al

pubmed.ncbi.nlm.nih.gov/41729464/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Interrogating the immune landscape of microsatellite stable RAS-mutated colon cancer - PubMed To explore the immune microenvironment of RAS-mutated (RASmt) microsatellite stable (MSS) colon cancer (CC), we retrospectively performed whole exome sequencing, RNA sequencing, and robust digital pathology analyses and studied immune markers in a cohort of 161 patients treated with standard-of-care …

pubmed.ncbi.nlm.nih.gov/41733106/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Elexacaftor/Tezacaftor/Ivacaftor for Cystic Fibrosis and Rare CFTR Variants: In Vitro Translation to a Phase 3, Double-Blind, Randomized, Placebo-controlled Trial and Real-World Study - PubMed In vitro, clinical, and real-world data support elexacaftor/tezacaftor/ivacaftor treatment in people carrying a range of CFTR variants and no F508del. The response of 84% of rare CFTR variants that produce protein to protein-stabilizing therapy suggests variants in many regions of the protein causes …

pubmed.ncbi.nlm.nih.gov/41738096/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Impact of Mobilization Dose on Outcome of Critically Ill Patients Receiving Mechanical Ventilation-A target trial emulation using data from the TEAM trial - PubMed Prolonged mobilization when only lower ICU mobility scale levels could be achieved were associated with increased 28-day mortality.

pubmed.ncbi.nlm.nih.gov/41738127/

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Clinical utility of lung biopsy in fibrotic interstitial lung disease - PubMed Lung biopsy has traditionally played a fundamental role in addressing diagnostic uncertainty and guiding management of fibrotic interstitial lung disease (fILD). Multiple lung biopsy procedures are available for evaluation of fILD, including bronchoscopic techniques such as transbronchial biopsy and …

pubmed.ncbi.nlm.nih.gov/41738223/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

p19ARF Deficiency Disrupts Lung and Lipid Homeostasis Resembling the Human Alveolar Proteinosis - PubMed The alternative reading frame (ARF) protein, encoded by the CDKN2A locus, is well-recognized for its role in tumor suppression. Emerging evidence has highlighted ARF as a critical regulator of innate immunity and inflammation, with links to increased susceptibility to cardio-metabolic diseases. This …

pubmed.ncbi.nlm.nih.gov/41738246/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Dyslipidemia in Diabetes: Navigating a Complex Landscape for Improved Cardiovascular Outcomes - PubMed Cardiovascular diseases are the leading cause of global mortality, accounting for roughly one-third of all deaths. Dyslipidemia is a key risk factor for atherosclerotic cardiovascular disease (ASCVD) and often coexists with diabetes, which exacerbates ASCVD risk. Despite the comprehensive management …

pubmed.ncbi.nlm.nih.gov/41743491/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Vascularised Composite Allotransplantation: Emerging Applications in Reconstructive Surgery and Solid Organ Transplantation - PubMed Vascularised composite allotransplantation (VCA) has an evolving role in the reconstruction of complex functional and aesthetic deficits non-amenable to autologous or implant-based reconstructive modalities. International applications of VCA span upper extremity, face, abdominal wall, uterus, and pe …

pubmed.ncbi.nlm.nih.gov/41752645/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Final overall survival results from EORTC 1333/PEACE-3 trial of enzalutamide plus radium-223 in metastatic castration-resistant prostate cancer - PubMed The final analysis of this study confirmed that the combination of enzalutamide with Ra223 significantly improved not only rPFS but also OS as first-line therapy for mCRPC versus enzalutamide alone. Co-administration of a bone-protecting agent is required to reduce skeletal complications.

pubmed.ncbi.nlm.nih.gov/41763609/

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Papers authored/co-authored by staff/affiliates of SVHG @svuh.bsky.social

02.03.2026 12:32 👍 0 🔁 0 💬 1 📌 0

Effect of psychological interventions on depressive symptoms in the long term after acquired brain injury: A systematic review and meta-analysis - PubMed This systematic review and meta-analysis was conducted to evaluate the effectiveness of psychological therapies applied more than one year after an acquired brain injury (ABI) in reducing depressive symptoms. A systematic literature search of databases yielded 48 studies that evaluated a psychologic …

pubmed.ncbi.nlm.nih.gov/40343850/

23.02.2026 11:10 👍 0 🔁 0 💬 0 📌 0

European survey on laser safety management in medical settings - PubMed The survey results indicate that the standard of medical laser safety arrangements vary considerably between European countries. This indicates there is work to be done to ensure that a consistent approach is taken across Europe to minimise laser risks to workers and patients.

pubmed.ncbi.nlm.nih.gov/41692665/

23.02.2026 11:10 👍 0 🔁 0 💬 1 📌 0

Development of a Core Outcome Set for research studies with older adults in the Emergency Department-CREAT-ED: A multi-stage study protocol - PubMed Development of a Core Outcome Set for research studies with older adults in the Emergency Department-CREAT-ED (COMET) initiative 2749 COMET Initiative | Development of a Core Outcome Set for research studies with older adults in the Emergency Department-CREAT-ED. https://www.comet-initiative.org/Stu …

pubmed.ncbi.nlm.nih.gov/41692798/

23.02.2026 11:10 👍 0 🔁 0 💬 1 📌 0

Building a Robust Investigator-Initiated Platform: The I-CARE Experience - PubMed Investigator-initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I-CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 coun …

pubmed.ncbi.nlm.nih.gov/41693257/

23.02.2026 11:10 👍 0 🔁 0 💬 1 📌 0

Surrogate Endpoints for Overall Survival in Advanced Hepatocelluar Carcinoma in the Era of Immunotherapy: A Trial Level Meta-Analysis - PubMed The correlation between HR-PFS and HR-OS is weak in 1st-line RCTs in advanced HCC where OS remains the most appropriate endpoint. There is a strong association between HR-PFS and HR-OS for 2nd-line RCTs, suggesting that PFS is a suitable surrogate endpoint in that setting.

pubmed.ncbi.nlm.nih.gov/41694651/

23.02.2026 11:10 👍 0 🔁 0 💬 1 📌 0

St Vincent's Healthcare Group Libraries

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