Cardiovascular Research Cluster (CVRC)

Measurement of turbulent kinetic energy with colour Doppler echocardiography and particle tracing velocimetry in an ex-vivo aortic stenosis model - PubMed In this ex-vivo AS model, both TKE measurement methods successfully differentiated severe from non-severe AS. These findings underscore the potential importance of ultrasound colour Doppler echocardiography in estimating energy loss through turbulence, paving the way for the development of a new dia …

New publication: Measurement of turbulent kinetic energy with colour Doppler echocardiography and particle tracing velocimetry in an ex-vivo aortic stenosis model. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41584505/
#CVRCBern

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development - PubMed Congenital heart disease (CHD), the most common human birth defect, often results from disruptions in gene regulatory networks (GRNs) that control cardiac lineage specification and cell type identity during heart development. A conserved core set of cardiac transcription factors (TFs) orchestrates t …

New publication: Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41509364/
#CVRCBern @mosterwalder.bsky.social

Percutaneous left atrial appendage closure with concomitant dual-device implantation: a single-center observational study - PubMed In this small cohort of patients with complex multilobed LAA anatomy, concomitant implantation of two Amplatzer devices proved to be a feasible strategy with acceptable short-term safety, although potentially associated with an increased risk of pericarditis.

New publication: Percutaneous left atrial appendage closure with concomitant dual-device implantation: a single-center observational study. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41503611/
#CVRCBern

Future directions in viscoelastic hemostatic assay usage in bleeding patients - PubMed VHAs are valuable tools for bleeding management but remain limited by platform heterogeneity, incomplete assay specificity, and modest predictive accuracy. Future research should focus on assay standardization, dual platelet inhibition in fibrinogen assays, and improved discrimination of coagulation …

New publication: Future directions in viscoelastic hemostatic assay usage in bleeding patients. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41384757/
#CVRCBern

Pole-To-Pole 3D Radial Trajectory Designs Improve Image Quality and Quantitative Parametric Mapping in the Brain and Heart - PubMed Acquiring nearly opposing spokes in 3D radial trajectory designs compensates phase inconsistencies without requiring additional corrections, which improves quantitative imaging and anatomical visualizations.

New publication: Pole-To-Pole 3D Radial Trajectory Designs Improve Image Quality and Quantitative Parametric Mapping in the Brain and Heart. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41486091/
#CVRCBern

All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level A living cell is a nonequilibrium thermodynamic system where, nevertheless, a notion of local equilibrium exists. This notion applies to all micro- and nanoscale aqueous volumes, each containing a large number of molecules. This allows one to define ...

New publication: All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level.
Congratulations to the authors!
pmc.ncbi.nlm.nih.gov/articles/PMC...
#CVRCBern

DDR1 Regulates Femoral Arterial Calcification in Lower-Extremity Artery Disease Through NF-Kappa B Activation - PubMed This study identifies DDR1 as a key driver of calcification in LEAD, operating through NF-κB activation and the expression of calcifying proteins. Targeting DDR1 may offer a novel therapeutic approach to prevent MAC in LEAD.

New publication: DDR1 Regulates Femoral Arterial Calcification in Lower-Extremity Artery Disease Through NF-Kappa B Activation. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41399911/
#CVRCBern

A comprehensive workflow for CCTA and OCT data fusion with 3D printing validation: advancing patient-specific testing environments for percutaneous coronary intervention devices - PubMed We present a novel workflow to produce high-resolution patient-specific phantoms of coronary arteries.

New publication: A comprehensive workflow for CCTA and OCT data fusion with 3D printing validation: advancing patient-specific testing environments for percutaneous coronary intervention devices. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41430242/
#CVRCBern

Real-Time Fluoroscopic Assessment of Underexpansion Predicts Hemodynamic Valve Deterioration Following TAVR With Balloon-Expandable Device - PubMed Underexpansion of balloon-expandable THVs is associated with an increased risk for HVD at mid-term follow-up.

New publication: Real-Time Fluoroscopic Assessment of Underexpansion Predicts Hemodynamic Valve Deterioration Following TAVR With Balloon-Expandable Device. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41240026/
#CVRCBern

The DBMR is pleased to announce that Prof. Lucio Barile, Institute for Translational Research (IRT), Università Svizzera Italiana (USI), Lugano and Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland will have a special lecture at our DBMR Research Conference. tinyurl.com/9w2r8bp7

Last week to apply!
Want to attend meetings & present your work?
LS2 & SCNAT are offering PhD Travel Grants (up to CHF 1400) for conferences between Mar-Sep 2026!
You must present (poster or talk) + be an LS2 member.
🗓️ Apply by March 1, 2026: buff.ly/Pj80DRo...

MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells - PubMed The cardiac ryanodine receptor (RyR2) constitutes the molecular basis of the process of calcium-induced calcium release where activation of RyR2s can be locally regenerative. Here, we present purely optical data of RyR2 distribution with sub-molecular resolution by applying 3D MINFLUX microscopy. Us …

New publication: MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells. Congratulation to the authors!
pubmed.ncbi.nlm.nih.gov/41423693/
#CVRCBern

The '10 commandments' for the 2025 focused update of the 2019 ESC/EAS guidelines for the management of dyslipidaemias - PubMed The '10 commandments' for the 2025 focused update of the 2019 ESC/EAS guidelines for the management of dyslipidaemias

New publication: The ‘10 commandments’ for the 2025 focused update of the 2019 ESC/EAS guidelines for the management of dyslipidaemias. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41416697/
#CVRCBern

Low-Density Lipoprotein Cholesterol Levels and Neoatherosclerosis After STEMI: A Secondary Analysis of the CONNECT Randomized Clinical Trial - PubMed ClinicalTrials.gov Identifier: NCT03440801.

New publication: Low-Density Lipoprotein Cholesterol Levels and Neoatherosclerosis After STEMI - A Secondary Analysis of the CONNECT Randomized Clinical Trial. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41405905/
#CVRCBern

Watchman FLX versus Watchman 2.5 for left atrial appendage closure: a propensity score-matched analysis - PubMed In a large dual-centre cohort of consecutive, successful LAAC procedures using two iterations of the Watchman device, the Watchman FLX was associated with significantly lower rates of both DRT and PDL compared to the Watchman 2.5.

New publication: Watchman FLX versus Watchman 2.5 for left atrial appendage closure: a propensity score-matched analysis. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41489742/
#CVRCBern

Type B Aortic Dissection in Patients Aged 30 Years or Younger: A Retrospective Multicentre Study - PubMed In young patients, TBAD predominantly occurs in the context of HTAD. Both open and endovascular repair are associated with excellent early outcomes and mid-term survival. However, HTAD remains a significant predictor of recurrent aortic interventions.

New publication: Type B Aortic Dissection in Patients Aged 30 Years or Younger: A Retrospective Multicentre Study. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41392201/
#CVRCBern

International Day of Women and Girls in Science 👩‍🔬🎉

Heute feiern wir die Frauen in der Wissenschaft – an unserer Universität und weltweit!

Entdecken Sie Porträts und Videos von Wissenschaftlerinnen der Universität Bern: www.unibe.ch/universitaet/…

#WomenInScience #February11

Pulsed-field ablation demonstrates superior pulmonary vein isolation durability at 90 days: Pooled analysis of protocol-mandated remapping data - PubMed Pulsed-field ablation demonstrates superior pulmonary vein isolation durability at 90 days: Pooled analysis of protocol-mandated remapping data

New publication: Pulsed-field ablation demonstrates superior pulmonary vein isolation durability at 90 days: Pooled analysis of protocol-mandated remapping data. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41397499/
#CVRCBern

Functional and biochemical biomarkers of cardiac graft quality measured during normothermic ex situ heart perfusion in a porcine model of donation after circulatory death - PubMed Donation after circulatory death (DCD) provides excellent patient outcomes in heart transplantation and substantially increases graft availability. The lack of validated biomarkers for graft function constrains reliable graft assessment and highlights the need for more effective assessment strategie …

New publication: Functional and biochemical biomarkers of cardiac graft quality measured during normothermic ex situ heart perfusion in a porcine model of donation after circulatory death. Congratulations to the authors! pubmed.ncbi.nlm.nih.gov/41391783/ #CVRCBern @slongnus.bsky.social

The call for nominations for the 2025 Benoît Pochon Prize for an outstanding PhD or MD-PhD thesis conducted at the DBMR and defended in 2025 is now open. ✍️ Send us your nomination until March 10 ➡️ tinyurl.com/yc5ept89 @medfacultyunibe.bsky.social

Knowledge @ Noon – 10 Mar 2026 | 12–13 CET (Zoom)

Lunch-hour webinar with:
🔹 Irene Díaz-Moreno: FEBS funding & fellowships
🔹 Nicholas Draeger: long-term financing for innovators

Free to join online! Register today: meetings.ls2.ch/knowledge-at...

Sex-specific cardiac ageing and sympathetic compensation: a translational study - PubMed Age-related cardiac changes affect both women and men in similar ways, but are more pronounced in women-likely reflecting a greater decline in sex hormones. This is associated with more prominent compensatory mechanisms to offset their disadvantage of having a smaller heart. Animal and tissue models …

New publication: Sex-specific cardiac ageing and sympathetic compensation: a translational study. Congratulations to the authors! pubmed.ncbi.nlm.nih.gov/41367061/ #CVRCBern

Physician Modification of the TREO Stent Graft Using a Customized 3D-Printed Template (TREO FIT, Terumo Aortic, UK) - PubMed The use of a customized 3D-printed and sterilized silicone template of patient's reno-visceral aorta facilitates the creation and precise position of the fenestration in PMEG. Further development should aim to improve the template respecting aortic kinking/angulation.Clinical ImpactThe use of a cust …

New publication: Physician Modification of the TREO Stent Graft Using a Customized 3D-Printed Template (TREO FIT, Terumo Aortic, UK). Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41368850/
#CVRCBern

Mini-sternotomy for direct right atrial dialysis catheter placement in a child with central venous occlusion - PubMed We report the case of a pediatric patient with kidney failure and bilateral central venous occlusion, in whom conventional dialysis access was no longer feasible. Following multidisciplinary evaluation, a dialysis catheter was surgically inserted directly into the right atrium via a lower mini-stern …

New publication: Mini-sternotomy for direct right atrial dialysis catheter placement in a child with central venous occlusion. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41364179/
#CVRCBern

Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement: A Post Hoc Analysis of the SCOPE I Randomized Clinical Trial - PubMed ClinicalTrials.gov Identifier: NCT03011346.

New publication: Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41364435/
#CVRCBern

Electrodiffusion in cardiac intercalated disc nanostructures alters cell-cell action potential transmission via ephaptic coupling: A model study - PubMed Ephaptic coupling modulates and assists cardiac action potential (AP) propagation in conjunction with gap junctional coupling. Ephaptic interactions rely on negative extracellular potentials within narrow intercellular clefts in intercalated discs (IDs) which influence the Na⁺ current in …

New publication: Electrodiffusion in cardiac intercalated disc nanostructures alters cell–cell action potential transmission via ephaptic coupling: A model study. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41275402/
#CVRCBern

Transcatheter Treatment of Bicuspid Aortic Valve Stenosis: From Observational Studies to Randomized Clinical Trials - PubMed Bicuspid aortic valve (BAV) disease is the most common congenital heart abnormality, which affects up to 2% of the population and significantly increases the lifetime risk of aortic stenosis and the need for valve replacement. While surgical aortic valve replacement (SAVR) remains the standard of ca …

New publication: Transcatheter Treatment of Bicuspid Aortic Valve Stenosis: From Observational Studies to Randomized Clinical Trials. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41431655/
#CVRCBern

The CVRC Annual Meeting 2026 is happening today! We are excited to learn more about the multiple cardiovascular topics under investigation in fundamental, translational and clinical research in Bern!

Effect of age and sex on cardiac magnetic resonance native T1 mapping and synthetic extracellular volume - PubMed This CMR study demonstrates that native T1 and ECV are influenced not only by sex and age, but also by their interaction, as well as by cardiac chamber size and heart rate. These factors should be jointly considered when interpreting myocardial tissue parameters in older individuals.

New publication: Effect of age and sex on cardiac magnetic resonance native T1 mapping and synthetic extracellular volume. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/40882774/
#CVRCBern

Want to attend meetings & present your work?
LS2 & SCNAT are offering PhD Travel Grants (up to CHF 1400) for conferences between Mar-Sep 2026!
You must present (poster or talk) + be an LS2 member.
🗓️ Apply by March 1, 2026: buff.ly/Pj80DRo...
#TravelGrant #Conference #PhD