Matteo Calcagnile

Usually harmless in the throat, meningococcus can turn deadly by crossing barriers to the brain—and may even hide inside our cells. A complex invader still full of mysteries.

#IDSky #Microbiology #microsky #mevosky

doi.org/10.3389/fcim...

Neisseria meningitidis uses the methylcitrate cycle to detoxify propionate. Carbon sources and bicarbonate influenced propionate toxicity. Mutants lacking prpB/C are sensitive to propionate, and kbuT enables uptake of α-ketobutyrate.
#IDSky #Microbiology #microsky #mevosky

Currently, we are working on a peper on soil microbiota. We observed a similar shift in underground water and in soil. Thank you for your question

Pirin, a redox-sensitive modulator of beta-oxidation, generates hydroxyl radicals and interacts with CatR, the transcriptional repressor of the major vegetative catalase gene in Streptomyces Pirins are iron-containing proteins conserved throughout evolution, which have been implicated in diverse cellular processes, mostly associated with s…

We found that Pirin, a redox-sensitive modulator of β-oxidation in Streptomyces, generates radicals as a signal to activate antioxidant systems and interacts with CatR, the repressor of catalase

Evolutionary conservation of redox crosstalk?🔬✨

www.sciencedirect.com/science/arti...

We found that Pirin, a redox-sensitive modulator of β-oxidation in Streptomyces, generates radicals as a signal to activate antioxidant systems and interacts with CatR, the repressor of catalase

Evolutionary conservation of redox crosstalk?🔬✨
#mevosky #EvoBio #MicroSky

doi.org/10.1016/j.mi...

Per- and polyfluoroalkyl substances (PFAS) as environmental drivers of antimicrobial resistance: insights from genome sequences of Klebsiella grimontii and Citrobacter braakii isolated from contaminat... Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals widely used for industrial applications since the 1940s. PFAS are extremely persistent in the environment, to the extent that they hav...

🌱 PFOA alters soil microbial communities, boosting K. grimontii and C. braakii, both carrying antibiotic resistance genes and virulence factors.
📈 PFOA increases resistance gene transcription, raising concerns about soil as a reservoir for AMR pathogens.
#PFAS #microbiomesky #Microbiology #MicroSky

Genome duplication in a long-term multicellularity evolution experiment - Nature In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...

1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.

www.nature.com/articles/s41...