MV Mazzuoli

Checkout our latest preprint which is a real lab-wide effort to map antibiotic stress signatures across the pneumococcal pangenome. All findings have also been incorporated in PneumoBrowse 2.0.
www.biorxiv.org/content/10.6...

First week as a visiting scholar in the @nizet.bsky.social lab at @ucsdhealthsci.bsky.social ! Excited to learn from everyone in the lab and very grateful for the warm welcome. Already in love with SoCal! ☀️ 🏄‍♀️

The virulence regulator CovR boosts CRISPR-Cas9 immunity in Group B Streptococcus - Nature Communications CRISPR-Cas9 is an adaptive immune system that protects bacteria against invading DNA. Here, the authors show that the master virulence regulator CovR controls the CRISPR-Cas9 system in Streptococcus a...

OUT NOW! We uncovered a coordinated regulation of CRISPR-Cas9 immunity and virulence in GBS.
Could this enhance bacterial immune repertoires during infection? Have a read:
🔗 www.nature.com/articles/s41...

👏 congrats to all co-authors!

The virulence regulator CovR boosts CRISPR-Cas9 immunity in Group B Streptococcus - Nature Communications CRISPR-Cas9 is an adaptive immune system that protects bacteria against invading DNA. Here, the authors show that the master virulence regulator CovR controls the CRISPR-Cas9 system in Streptococcus a...

Cool paper by @mvmazzuoli.bsky.social from her time at the Firon lab @pasteur.fr
The virulence regulator CovR boosts CRISPR-Cas9 immunity in Group B Streptococcus doi.org/10.1038/s414...

HU promotes higher order chromosome organization and influences DNA replication rates in Streptococcus pneumoniae Abstract. Nucleoid-associated proteins (NAPs) are crucial for maintaining chromosomal compaction and architecture, and are actively involved in DNA replica

ONLINE now! 👇🏼 @narjournal.bsky.social

Only an across-the-Alps collaboration could decipher pneumococcal chromosome biology!

academic.oup.com/nar/article/...

@jwveening.bsky.social and all the co-authors!👏🏻

OUT NOW! 👇🏼We built a make-or-break Prime editing tool—have a read to discover how it’s changing the way we do genomic engineering.

www.nature.com/articles/s41...

@JWVeening @AxelJans & all others authors! 👏🏻

Make-or-break prime editing for genome engineering in Streptococcus pneumoniae - Nature Communications Genome engineering in bacteria remains a complex multistep process. Here, the authors developed make-or-break Prime Editing, a precise method for genetic modification in Streptococcus pneumoniae that ...

www.nature.com/articles/s41...

1/ 🔬 Our work, "Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae", is now published in Nature Communications.
Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵

Link : www.nature.com/articles/s41...

Now updated!

www.biorxiv.org/content/10.1...