Marco Gallo

BCM Neurosurgery's Dr. Ben Deneen has received the inaugural Bert O'Malley Award for Outstanding Basic Research

“It is such an honor to receive an award named in honor of the most iconic figure in BCM cancer research. This award reflects the hard work and dedication of the numerous trainees and lab members here at Baylor College of Medicine who are committed to curing brain cancer.” -Dr. Ben Deneen

Dr. Ben Deneen receives the inaugural Bert O'Malley Award for Outstanding Basic Research during this year's Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine retreat.

#NEWS: #BCMNeurosurgery's Dr. Ben Deneen recently received the inaugural Bert O'Malley Award for Outstanding Basic Research at this year's Dan L Duncan Comprehensive Cancer Center at @bcmhouston.bsky.social annual retreat.

A functional perspective on astrocyte heterogeneity

"A functional perspective on astrocyte heterogeneity"
http://dlvr.it/TPML8T

Benjamin Deneen, Wookbong Kwon & @m-r-williamson.bsky.social
@cp-trendsneuro.bsky.social
#SfN2025

a penguin wearing a red bandana and a tie looks through binoculars Alt: a penguin wearing a red bandana and a tie looks through binoculars

Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below

shorturl.at/x0cSs

Français : L’image montre un vaste champ de coquelicots rouges éclatants sous un ciel sombre et orageux. Les fleurs, d’un rouge vif, contrastent fortement avec les tons gris et noirs du paysage environnant. Le soleil perce entre les nuages à l’horizon, projetant un rayon lumineux qui illumine certaines fleurs au premier plan. Les coquelicots, aux pétales ouverts et délicats, semblent danser doucement dans la lumière. L’atmosphère est à la fois dramatique et paisible — un moment suspendu entre la tempête et la sérénité, entre l’ombre et la lumière. English: The image shows a vast field of bright red poppies beneath a dark, stormy sky. The vivid red flowers stand out sharply against the gray and black tones of the surrounding landscape. The sun breaks through the clouds on the horizon, casting a beam of light that illuminates some of the poppies in the foreground. Their open, delicate petals appear to sway gently in the light. The overall mood is both dramatic and peaceful — a suspended moment between storm and calm, between shadow and light.

Lest We Forget
N'oublions Jamais

Veterans Day 2025 In honor of Veterans Day, Dr. Timothy Porea, professor of pediatrics-hematology and oncology at Baylor College of Medicine, reflects on his time in U.S. Navy and military medicine. Thank you to all veterans who support Baylor and the community.

In honor of Veterans Day, Dr. Timothy Porea shares how he uses his time in the U.S. Navy and military medicine to help current military students. Watch the interview with Dr. Porea on YouTube: https://bit.ly/4p6AUi0 Thank you to all veterans who support Baylor and the community. #VeteransDay

Epigenetic Replication during DNA Replication - Replicating histones and DNA methylation YouTube video by theCrux

DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:

Congratulations, Daniel!

This week, that idea reached patients: Viral-mimicry priming + anti-PD-1 in relapsed/refractory NK/T-cell lymphoma delivered 47.6% complete responses, 66.7% ORR, and ~50% 2-year OS, even after prior PD-1 failure (Huang, Cancer Discovery 2025).

Thanks to all collaborators, especially Dr Sameer Agnihotri at @news.upmc.com

EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism - Acta Neuropathologica Communications It is currently understood that the characteristic loss of the repressive histone mark H3K27me3 in PFA ependymoma and diffuse midline glioma (DMG) are caused by complementary mechanisms mediated by EZ...

EZHIP has been puzzling us for years because of its incompletely understood role in pediatric brain tumors. Here we report new functions for EZHIP and that EZHIP is not only mutated in PFA ependymoma, but also in K27M+ HGGs with EGFR mutations.
actaneurocomms.biomedcentral.com/articles/10....

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Scientists uncover nuclear droplets that link multiple leukemias revealing new therapeutic target A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow...

Scientists uncover nuclear droplets that link multiple #leukemias revealing new #therapeuticTarget.
@gandhardatar.bsky.social @sciencyelmira.bsky.social @goodell-lab.bsky.social @superscijew.bsky.social et al
@cellcellpress.bsky.social @bcmhouston.bsky.social www.bcm.edu/news/scienti...

(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.

The November issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Diwakar Davar, @overacrelab.bsky.social, et al. showing sucralose consumption ablates cancer immunotherapy response via microbiome disruption - read that & more: aacrjournals.org/cancerdiscov...

Mind captioning: Evolving descriptive text of mental content from human brain activity Nonverbal thoughts can be translated into verbal descriptions by aligning semantic representations between text and the brain.

Our "mind captioning" paper is now published in Science Advances @science.org .
The method generates descriptive text of what we perceive and recall from brain activity — a linguistic interpretation of nonverbal mental content rather than language decoding.

doi.org/10.1126/scia...

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

Ludwig Oxford welcomes Dr Manav Pathania Ludwig Oxford is delighted to welcome Dr Manav Pathania as an Assistant Member of the Ludwig Institute for Cancer Research, Oxford Branch.

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned!

shorturl.at/thpyK