Jenn Orthmann Murphy

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles www.science.org/doi/10.1126/...

thank you!!

thank you! happy new year!

Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination Cuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre-myelina...

Our Paper is out! We studied cortical microglia and regenerating oligodendrocyte (OL) interactions. In short: demyelination induces transiently reactive microglia and depletion of these reactive microglia increase recovering OL number onlinelibrary.wiley.com/doi/10.1002/...

OMg outing at the Flyers game last night - they won and we had fun celebrating 7 years of Christine lab managing

Expanding the Early Childhood Manifestations of ITPR1 Heterozygous Variants Beyond Congenital Ataxia and Gillespie Syndrome | Neurology Genetics Background and ObjectivesHeterozygous ITPR1 variants have been previously linked to multiple human disease phenotypes, including congenital ataxia and Gillespie syndrome. Previous reports have describ...

Out today! Taking the diagnostic challenges from clinic into the lab bench to learn from our rare disease patients
Thanks to David Yule and his team for partnering with us in this project
www.neurology.org/doi/10.1212/...

#Gliadelphia Fall 2025 conference is underway with an incredible FLASH presenter talk session to introduce the poster session!!

Fantastic session this morning at #ANA2025 on 'Communicating your Science' with Drs. S. Andrew Josephson, @rkchoi.bsky.social, Sara Manning and Kelly Sloane

i can confirm this is true, unfortunately, from personal experience

Gong, @jennoligomyelin.bsky.social, Abrams et al. present two novel, disease-causing genetic variants of #connexin 47. In vitro assays and MD simulations reveal unique mechanisms that relate connexin 47 mutations to severities of Pelizaeus–Merzbacher-like disease 1. rupress.org/jgp/article/...

We had a beautiful day for the Philly WalkMS for @nationalmssociety.bsky.social . Team #Gliadelphia @pennmedicine.bsky.social MS Division and @pennngg.bsky.social was there to support our friends, family and patients

GitHub - PennSIVE/bossr: R package for BOSS algorithm R package for BOSS algorithm. Contribute to PennSIVE/bossr development by creating an account on GitHub.

Find it here: github.com/PennSIVE/bossr

Thanks to a wonderful collaboration with Caleb Bae and Taki Shinohara in Biostatistics.

FAST: Fast, Free, Consistent, and Unsupervised Oligodendrocyte Segmentation and Tracking System To develop reparative therapies for neurological disorders like multiple sclerosis (MS), we need to better understand the physiology of loss and replacement of oligodendrocytes, the cells that make my...

Excited to Share FAST - a free and user-friendly way to segment and track cells in longitudinal in vivo imaging sets. We developed it for #oligodendrocytes but it also works for #astrocytes! #Gliadelphia @pennmedicine.bsky.social
www.eneuro.org/content/12/2...

#GRCGlia25 #DwightBirdles is hanging out with his family!

TBCK-deficiency leads to compartment-specific mRNA and lysosomal trafficking defects in patient-derived neurons Monogenic pediatric neurodegenerative disorders can reveal fundamental cellular mechanisms that underlie selective neuronal vulnerability. TBCK-Encephaloneuronopathy (TBCKE) is a rare autosomal recess...

Standing up for science by sharing this labor of ❤️
out today!

What underlies selective neuronal vulnerability in rare 🧬 disorders when the gene is ubiquitously expressed?

TBCK patient derived neurons have axonal predominant lysosomal and mRNA trafficking defects, 👇🏽
www.biorxiv.org/content/10.1...

Today I was honored to represent the CSF1R-ALSP workgroup at the GLIA-CTN Scientific Conference here in #Gliadelphia and support Sisters' Hope Foundation and the CSF1R-ALSP community. Shown are workgroup members who were able to attend in person.

Congratulations to Hannah Loo, the first lab graduate, on her thesis defense and submission of her paper