Dan Isom

Grateful to our organizers—@danisomlab, Jennifer Arcuri, and Kerry Burnstein—and to everyone who made the retreat such a success. Here’s to the next chapter. 🌴🔬

The result: new collaborations, new ideas, and a stronger sense of departmental community than ever.

The takeaway is clear—our science is cutting-edge, and bringing people together like this is essential for moving both individual and team discoveries forward.

We just wrapped up the 7th Molecular & Cellular Pharmacology Retreat in the Florida Keys, and the energy was incredible.

Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work.

PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators Periplasmic display in yeast is a promising but underdeveloped method for screening and studying genetically encoded biomolecules. We present PIONEER, a modular platform that localizes peptides, prote...

PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry www.jbc.org/article/S002...

Help me Challenge Cancer! The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTe...

Support my running of the 5K! Funds go directory to research labs @SylvesterCancer: dolphinscancerchallenge.com/participant/...

These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did

There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations.

"A recent study employing parallel mutagenesis of titratable residues in GPR68 identified a conserved triad of buried acidic residues in proton sensing GPCRs. Here, too, neutral mutations to these sites shift pH50 but do not abolish proton-mediated receptor activation."

I have received many requests for this, so I am sharing it here. I hope it works (password: 7i+fFdMG) @Pap_Corps @SylvesterCancer @danIsomLab:
tinyurl.com/Pap-Corps-EC...

Thanks Nina!

Welcome! You are invited to join a webinar: The Pap Corps Champions for Cancer Research Endowed Chair. After registering, you will receive a confirmation email about joining the webinar. Chair ceremony for Dr. Daniel G. Isom

miami.zoom.us/webinar/regi...

The combined single-day profit of the top 25 US companies would fully fund the annual $3.2B NIGMS budget.

Happy Thanksgiving from Miami.

Can a Diabetes Drug and Immunotherapy Help Treat Brain Cancer? - InventUM Defne Bayik, Ph.D., is pioneering new treatments to find combination therapies that may help T-cell response against glioblastoma.

Yay Defne! news.med.miami.edu/can-a-diabet...

In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂

Advances in yeast synthetic biology for human G protein–coupled receptor biology and pharmacology G protein–coupled receptors (GPCRs) are the largest family of transmembrane receptors in humans. Over 800 GPCRs regulate the (patho)biology of every o…

Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology.
tinyurl.com/2p88y72h

What a wonderful scientific retreat for UM Pharmacology this week @bakerscayresort. Time is running out to join our faculty and enjoy the Keys and science for yourself! bit.ly/3GAxDD6

Looking for cool colleagues! Recruiting at assistant and associate levels. I am happy to answer any questions. www.nature.com/naturecareer...

Chicagoland.

SUP on Lake Tahoe today:

Happy to be among this fine assembly of protonators: https://www.biophysics.org/2023tahoe-protonreaction/program/daily-schedule

Sugar gold.

I would.

That bill is strangely pleasing.

Wow, SoCal feeling SoFlo.

Otterly astounding ;)

Love the graphic.

PIEZO1 action up close: https://www.nature.com/articles/s41586-023-06427-4

Cool, but SUPER TINY proteins: https://www.nature.com/articles/s41586-023-06328-6

I share your whoa!