Jee-Yon Lee

Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals - Nature Microbiology Using 21,561 individuals, the authors present a cross-sectional study of how gut microbiome signatures are associated with dietary intake patterns and with host health outcomes.

🧵 How does being a #vegan, #vegetarian or omnivore impact your gut #microbiome? 🥦 Find out in our new paper on gut microbiome signatures of vegan, vegetarian & omnivore diets & associated health outcomes across 21,561 individuals in @naturemicrobiol.bsky.social!🎉 1/10

www.nature.com/articles/s41...

Stable isotope fingerprinting can directly link intestinal microorganisms with their carbon source and captures diet-induced substrate switching in vivo Diet has strong impacts on the composition and function of the gut microbiota with implications for host health. Therefore, it is critical to identify the dietary components that support growth of spe...

We showed that #metaproteomics based "Stable isotope fingerprinting can directly link intestinal microorganisms with their carbon source and captures diet-induced substrate switching in vivo"
www.biorxiv.org/content/10.1...
Great work by Angie Mordant and Alfredo Blakeley-Ruiz @alfredob.bsky.social

Confronting risks of mirror life Broad discussion is needed to chart a path forward.

Gearing up vs the potential of building "mirror life"
A looming danger of bioengineered reversed-chirality bacteria and microbes.
www.science.org/doi/10.1126/... @science.org

Glad to share our preprint 🏃 **LongTrack**: long read metagenomics-based precise tracking of bacterial strains (and their genomic changes!) after 💩 fecal microbiota transplantation. A 4+ years journey and tour de force by ** @yufan01.bsky.social ** & team. A long 🧵 www.biorxiv.org/content/10.1...

Combinatorial, additive and dose-dependent drug–microbiome associations Nature - An analysis of 2,173 individuals from the MetaCardis cohort quantifies the individual and combinatorial effects of a range of drugs on host health, metabolome and gut microbiome in...

"Combinatorial, additive and dose-dependent drug–microbiome associations" by @inanna-nalytica.bsky.social investigates data from patients with cardiovascular disease within the MetaCardis consortium to disentangle the effect of drug combinations and other confounders (2021)

www.nature.com/artic...

This is figure 4, which shows collateral sensitivity and cross-resistance interactions between and within antibiotic classes.

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

An array of fruits and vegetables. Stock image.

A study in Scientific Reports finds that both high fruit and high vegetable intake were associated with lower depressive symptoms in people over 45 years old. Only moderate vegetable intakes were associated with lower depressive symptoms. https://go.nature.com/3ZDOIGL 🧪

A conserved bacterial genetic basis for commensal-host specificity Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...

How Lactiplantibacillus plantarum specifically recognizes the fruit fly foregut as a distinct physical niche?
Cool paper on host-microbiota interaction in @science.org : www.science.org/doi/10.1126/....

And a nice summary, aptly titled ‘Home Sweet Home’: www.science.org/doi/10.1126/...

Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…

New paper:

We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.

www.sciencedirect.com/science/arti...

Thrilled to share my latest research paper! It reveals how a high-fat diet may induce prolonged sorbitol intolerance following antibiotic-induced microbial depletion.
www.cell.com/cell/fulltex...