I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
Emma is an incredible mentor and scientist! Plus, Switzerland is a powerhouse of high-quality science. Don’t doubt to apply to this position.
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
We are hiring! 🧫 🧬 🚀
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens!
SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)
Excitability as a Design Principle in the Immune System https://www.biorxiv.org/content/10.1101/2025.08.31.673412v1
LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice https://www.biorxiv.org/content/10.1101/2025.08.28.672860v1
Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)
Our new review article led by Jordan Kramer:
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
As promised, a 'skeet' -orial on our paper published last week !
Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below!
www.science.org/doi/10.1126/...
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/
1/ Ever wonder how a clearly brilliant person – someone great a math and engineering and company building – can display shockingly unintelligent thinking when it comes to politics? Neuroscience has the answer!
Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!
Could you please add me to the pack? Thank you very much!
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
Our work led by Anna Huhn is now published!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything.
The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n)
doi.org/10.1242/dev....
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
Prior antigen experience of CAR T cells determines functional attributes and amenability to transcription factor-mediated functional enhancement
www.nature.com/articles/s41...
@koledegolier.bsky.social
www.nature.com/articles/s41...
Biologist, stop putting UMAP plots in papers!
Blogpost here: simplystatistics.org/posts/2024-1...
'The TME of Long Term Survival cases was distinguished by coinfiltration of T cells, B cells & plasma cells, along with upregulation of the PD-1/PD-L1 pathway. Remarkably, these prognostic associations were almost entirely restricted to tumors with high-epithelial content & the C4/DIF mol. subtype'
"(...) reinforcing 41BB costimulation on the day of vaccination did not result in a substantial improvement in vaccine responses. However, reinforcing 41BB costimulation on day 4 after vaccination, when 41BB expression levels were highest, resulted in a profound improvement in CD8+ T cell responses"
🖐️ Hi Mam! - A superantigen (MAM) goes to the head of the class (II) to find alternatives to TCRs for specific peptide:MHC binders doi.org/10.1038/s415...
This is a clever way to use synthetic biology: taking a toxin that overactivate the immune system (superantigen), rationally modify its core components and transform it into a platform of immunotherapy agents.
Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
Out this week @science.org by first release: Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.
https://buff.ly/4gvqKTz
From Shixin Ma, Sue Kaech @tcellogic.bsky.social and colleagues
#Immunology #immunometabolism
Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.
