"Saving Science by the Sea" – a piece on the importance of marine laboratories in advancing biomedical science, including the beginning of the Meselson-Stahl collaboration that ultimately elucidated the process of DNA replication:
www.science.org/doi/10.1126/...
Single-cell RNA sequencing data plotted by cell class and life stage
Our data suggests that the differences in body plan organization of larvae and adults is primarily based on differences in cell type composition and transcriptional state and that specific cellular complements have evolved to support the vastly different ecologies and behaviors of larvae and adults.
Here we study a hemichordate 𝘚𝘤𝘩𝘪𝘻𝘰𝘤𝘢𝘳𝘥𝘪𝘶𝘮 𝘤𝘢𝘭𝘪𝘧𝘰𝘳𝘯𝘪𝘤𝘶𝘮, a species with a complex lifecycle where the formation of the adult occurs through a dramatic metamorphosis transforms the planktonic larva into a burrowing benthic adult.
In many species the adult is formed not from an embryo, but through metamorphosis – the transformation of a larval body plan into an adult.
Even though this a common strategy across how this occurs at a molecular and cellular level remains unknown in many species.
Excited to share our recent work from @lowelab.bsky.social on the intersection of life history and cell type evolution: www.biorxiv.org/content/10.1...
