๐ฅ๐ฅ๐ฅ๐ฅ๐ฅ๐ฅ๐ถ๏ธ๐ถ๏ธ๐ถ๏ธ Hottest new lab in town, led by the exceptional @calumgabbutt.bsky.social, is recruiting it's first #PhD student. If you love #maths and somatic #evolution it could be your dream come true! ๐ถ๏ธ๐ถ๏ธ๐ถ๏ธ๐ฅ๐ฅ๐ฅ๐ฅ๐ฅ๐ฅ
Is artificial general intelligence (AGI) already here? A thoughtful & compelling case: www.nature.com/articles/d41...
"General intelligence can...emerge from simple learning rules applied at scale to patterns latent in human language: patterns [that] encode much of the structure of reality itself"
Too kind Duncan, thank you.
Open postdoc position in our lab @icr.ac.uk to develop a cfDNA test for #early detection of colorectal #cancer in inflammatory bowel disease #IBD:
jobs.icr.ac.uk/vacancies/14...
It's bench-to-bedside research, translating biology of pre-cancer evolution.
Funded by @bowelcanceruk.bsky.social
Are you fascinated by cancer biology and also โค๏ธ ๐ป ? Feel like this ->๐ป<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...
A big thank you to @bowelcanceruk.bsky.social and all their wonderful supporters for funding our research that aims to develop a blood test to predict bowel #cancer risk for people with inflammatory bowel disease #IBD. www.bowelcanceruk.org.uk/research/our... @icr.ac.uk
With the start of our new study trying to find causes of bowel cancer in young people hitting the headlines today: www.bbc.co.uk/news/article... I'm so glad to see bold efforts to raise awareness, like this giant 5x3m poster on the Croydon station platform I pass by on my to the lab each day
Cool new paper from @bloodgenes.bsky.social in @science.org. A common non-coding germline variant protects against clonal haem (CHIP) by modifying RNA regulatory networks. Wonder if CHIP protection is a tradeoff though - presumably some impact on immunity...? www.science.org/doi/10.1126/...
All I want for xmas is... combined cell segmentation and phenotyping with high accuracy from whole slide histology images with #Classpose (semantic segmentation). www.biorxiv.org/content/10.6...
From the inimitable @sohmandal.bsky.social @icr.ac.uk
Huge congratulations to Fran on being awarded the ERC Consolidator Grant! ๐
Such a well-deserved recognition of an outstanding trajectory and a truly creative, exciting proposal on T-cell clonal hematopoiesis.
Canโt wait to see the discoveries that come out of this project.
So proud of you! ๐โจ
We focused the first #CANPOP on our local SE England community, but would be delighted to open it up nationally or even internationally for #CANPOP2.
Our goal is to help grow the cancer popgen community. Please do shout if you'd like to join us (also we're open to ideas of how to organise this too)
Speakers were:
@carolinewatson.bsky.social (pre-leukaemia)
Verena Kรถrber (Oxford) - SFS modelling
@calumgabbutt.bsky.social - methylation lineage tracing
@benjaminwerner.bsky.social - ecDNA evolution
@zaccasimo.bsky.social - CNA phylogenetics
Liz Murchison (Cambridge) - transmissible cancer
We held the first #CANPOP symposium today (cancer population genetics club) @icr.ac.uk. 6 excellent & didactic talks, all applying mathematical #popgen theory to dissect somatic evolutionary dynamics: spanning the full range of pre-cancer, metastasis through to 6000 year old transmissible cancer...
First paper from the exceptional Marco Bezzi, group leader in our @cec-icr.bsky.social: a disease-matched syngeneic mouse modelling platform for prostate cancer evolution. Many results here, highlighted is MYC/MAPK driving castration resistance & remodelling tumour microenvrn Congrats! @icr.ac.uk
Fantastic opportunity from @turajliclab.bsky.social! ๐
The CanDy Lab is recruiting an Associate Scientist to drive cutting-edge cancer research across @cruk-mi.bsky.social and @crick.ac.uk.
A rare chance to lead, grow, and shape high-impact science ๐
www.cruk.manchester.ac.uk/career/mi-25...
@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude
Calling cancer data scientists! ๐ ๐ฝ ๐งฎ
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...
Congratulations Alvaro! And your exciting papers are following...
Ouse Valley Viaduct, Sussex, UK
๐จ๐จ๐จ
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! ๐
Further info: www.evomg-dn.eu and ๐
Both projects involve lots of collaboration, supervision, mentorship and training (& travel!) across our @evomg-dn.bsky.social network. They mandate motility across the #EU and partner countries too. Consequently I think the studentships will offer exceptionally rich #PhD experiences.
The second is about potential fitness costs of cancer drug resistance, and how we might exploit them using approaches like adaptive therapy. (building on our work with @mlockley.bsky.social in ovarian cancer: aacrjournals.org/cancerres/ar...). Description here: www.icr.ac.uk/study-and-ca...
The first is about developing new approaches to track cancer evolution from cell free DNA (cfDNA - liquid biopsy), and is a collaboration with industry partner nonacus.com Description here: www.icr.ac.uk/study-and-ca...
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus ๐คฏ Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
Great flash talks from Anton Patrikeev (HPV evolution in head and neck cancer) and Florian Gabel (resistance evolution in prostate cancer) both from our @cec-icr.bsky.social @icr.ac.uk #CrickCancerConf
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
thanks Vijay!
Here's @calumgabbutt.bsky.social's nice thread on our #EVOFLUx paper in @nature.com that uses fluctuating methylation to track cancer evolution
