@achimlother
Clinician Scientist @imit-freiburg.bsky.social, basic to translational research in intensive care, heart failure, pharmacology, epigenetics, and mineralocorticoid receptor signaling #Freiburg http://cardiovascularpharmacology.org
🧪 Is aldosterone a risk factor for atrial fibrillation?
👩⚕️ What is the evidence from clinical trials exploring MR antagonists in the prevention and treatment of #AF?
🧫 Which cellular and molecular mechanisms are involved?
Read more in our latest review www.ahajournals.org/doi/10.1161/...
Looking forward to an exciting 2025 meeting of the European Section of the Aldosterone Council - at beautiful Rome!
@aldolabz.bsky.social @boulkrounshee.bsky.social
Save the date!
Liebe Kolleginnen und Kollegen,
ganz herzlich laden wir Sie zur Veranstaltung „Neues aus der Intensivmedizin“ (NIM 2026) am Freitag, 16. Januar 2026 ab 18 Uhr in die Bibliothek der Frauenklinik ein.
@afluegler.bsky.social @tobi-wengenmayer.bsky.social
![Comic. PERSON 1: That movie was so good. Maybe even the greatest movie of all time question mark? PERSON 2: Yeah comma, but you said that about italics *Charlie’s Angels Colon: Full Throttle* period. Paragraph break. I question your judgement period. [caption] When people say “question mark” out loud as a rhetorical device, it always makes me want to say my other punctuation and formatting too.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreihxesft4pcq3aeu62qofxlnddonvqehkf7o2n4kwtot3a6zh6qj6y)
Comic. PERSON 1: That movie was so good. Maybe even the greatest movie of all time question mark? PERSON 2: Yeah comma, but you said that about italics *Charlie’s Angels Colon: Full Throttle* period. Paragraph break. I question your judgement period. [caption] When people say “question mark” out loud as a rhetorical device, it always makes me want to say my other punctuation and formatting too.
Question Mark
xkcd.com/3143/
Happy to share our recent paper, led by Elias Erny:
👉 Endothelial cell stop proliferating in heart failure despite VEGF ⏫
👉 transcription factors TCF19 and ATAD2 control endothelial cell proliferation and angiogenesis
rdcu.be/eGYpJ
Big thanks to all co-authors for the great collaboration #SFB1425
This!
Our latest preprint from the lab is now online:
- single nucleus RNAseq comparison of aldosterone/salt vs high fat diet/L-NAME induced HFpEF
- fibroblast specific MR knock-out
dx.doi.org/10.21203/rs....
We are looking forward to your thoughts and comments!
Enjoying excellent presentations and meeting with colleagues and friends at International Aldosterone Conference at San Francisco. Can't wait to see you again in Rome later this year!
admire-network.org/2025/06/02/a... @endocrinesociety.bsky.social
Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
Happy to share our recent review article on Extracorporeal Cardiopulmonary Resuscitation in refractory cardiac arrest published in @lancetrespirmed.bsky.social covering all aspects and recent evidence of #ECPR for in-hospital and out-of-hospital cardiac arrest #OHCA #IHCA
Open Access bit.ly/3HjVSsV
Abstract submission for the #ESAC2025 European Aldosterone Conference in Rome will open from June 1st to July 15th. Looking forward to your submissions!
Congratulations! @cibss.bsky.social @uni-freiburg.de
#SpatialTranscriptomics 👤 #Cardiomyopathy #HeartFailure
GeoMx
Cardiomyocyte #EndothelialCell Fibroblast segmented
44👤🫀 #TissueMicroArray
#MyocyteDisarray HCMpEF➡️⏬ribosome
#CardicFibrosis➡️⏫ACKR1+PLVAP+CCL14+ endothelium
UCHL1 PFKFB2 for HF progression
#EHJ 2025
academic.oup.com/eurheartj/ad...
We found that aldosterone induces atrial myopathy and increases the risk for #Afib, likely involving atrial stretch caused by LV diastolic dysfunction www.ahajournals.org/doi/10.1161/...
#Aldosterone alters cardiomyocyte states and changes cell-cell interactions, finally leading to atrial myopathy and atrial fibrillation.
www.ahajournals.org/doi/10.1161/... #afib Shout out to David Meral de.linkedin.com/in/david-mer...
New insights from the German VA-ECMO registry: Clinical use and predictors of outcome in venoarterial extracorporeal membrane oxygenation.
link.springer.com/article/10.1...
@tobi-wengenmayer.bsky.social
#Mechanobiology #RigiditySensing
Cellular mechanosignaling for sensing and transducing matrix rigidity
#YAP/TAZ
#Piezo
Mechanometabolism
Substrate with tunable stiffness
Cynthia Reinhart-King lab #CurrOpinCellBiol 2023
www.sciencedirect.com/science/arti...
Meta analysis suggests benefit of prone positioning for patients on #ECMO - RCT needed for definite answers. link.springer.com/article/10.1... @tobi-wengenmayer.bsky.social
It takes excellent research to move intensive care medicine forward: Happy to see exciting data, lively discussions, and many new project ideas at IMIT Science Day 2025…
Our NEW Primer on Thoracic aortic aneurysm is live today! By Berger, Dumfarth, Kreibich, Minatoya, Ziganshin & Czerny. Check it out here:
Program of the 46th International Aldosterone Conference is now online, see you July 10-11 at San Francisco, USA.
aldosterone.org
Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction. New paper by Jasmin Rettkowski, Timo Heidt, Nina Cabezas-Wallscheidt and colleagues
www.nature.com/articles/s41... @achimlother.bsky.social
Neue Episode von Notfallreform - how to? mit @karagiannidis.bsky.social @uniklinik-fr.bsky.social
open.spotify.com/episode/4OPd...
🌟 SAVE THE DATE: Talent Forum 2025!
🗓️ November 18–19
📍 @www.helmholtz-munich.de, Germany
Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research!
Apply by July 31 for a speaker spot —travel & accommodation covered.
🔜 Website coming soon!
Excellent review, thanks to the authors for putting this together www.nature.com/articles/s41...
Planning of the next ESAC meeting on aldosterone and MR is in full process. Mark your calendars and see you October 17-18 in Rome
admire-network.org/2024/05/15/s...
A new benchmarking study assesses methods for comparing chromatin contact maps in 3D genome research.
www.nature.com/articles/s41...
Schönberg (maps.app.goo.gl/9XcNPE3UjkVU...) with nice views of Freiburg, Alsace and maybe Alps, visit Vitra
www.design-museum.de,
tasty ice cream at www.dieeismanufaktur.de (close to Biology), walk through old town and enjoy cafe and some French patisserie at www.kolbenkaffee-freiburg.de
Insightful Editorial by Milton Packer cleaning up some myths on #Aldosterone and MR in heart failure treatment
www.sciencedirect.com/science/arti...