Giacomo Donati

Psoriasis-like disease prevents squamous skin tumor development by neutrophil-driven inflammation | PNAS Psoriasis is a chronic inflammatory skin disease affecting millions of people worldwide. Although growing evidence links chronic inflammation with ...

Our exciting collaboration paper is out 👇and investigates how chronic inflammation in the skin (psoriasis) prevents tumor development. 🔝👏👏Have a look 👀. Thanks for involving us in this important study 🙏🏾 Center for Cancer Research Medizinische Universität Wien

www.pnas.org/doi/10.1073/...

🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Bravo! @ryanrdriskell.bsky.social

Rete ridges form via evolutionarily distinct mechanisms in mammalian skin - Nature A spatial and single-cell transcriptomics study across multiple mammalian species identifies epidermal BMP signalling as a functional requirement for rete ridge formation, providing insight into ...

Ridges under the skin - paper in @nature.com www.nature.com/articles/s41...

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...

RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP

RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...

I am thrilled to share our paper introducing RBPscan, a novel approach to profile RNA–protein interactions in living cells. Free access link at the end ⬇️ 🧵 1/
www.cell.com/molecular-ce...

Excited to highlight a new preprint about mechanical contributions to tissue homeostasis, from the Manning group in collaboration with the amazing Carien Niessen and Sara Wickstrom @sarawickstrom.bsky.social labs, spearheaded by Dr. Somiealo Azote: www.biorxiv.org/content/10.6...

Single-cell susceptibility to viral infection is driven by variable cell states

www.sciencedirect.com/science/arti... #MicroSky

A competition model of multilineage priming and cell-fate decisions In development, cells navigate highly complex gene-regulatory landscapes to make fate choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity, and collective multi...

Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...

Check out our review on epithelial–microbiome interactions and their disruption in inflammatory skin disorders. + computational tools to study host–microbe crosstalk + ecological memory (epithelial and microbial memories) in barrier tissues. www.nature.com/articles/s41...

The G3BP stress-granule proteins reinforce the integrated stress response translation programme - Nature Cell Biology Smith and Bartel show that mRNA recruitment to stress granules imparts resistance to the integrated stress response translational shutdown.

The G3BP stress-granule proteins reinforce the integrated stress response translation programme
www.nature.com/articles/s41...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?

Yes, one can. with CUT&ID ✂️🪪

Spearheaded — singlehandedly — by @annanordin.bsky.social

No need of transgenesis, cloning and overexpression.

Check it out, it's fast and its works.

A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development Nature Cell Biology - The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is...

🚨 New paper out!
A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development
Here is the full paper: rdcu.be/eSWEs
🧵 A twittorial:
THREAD

Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth - Nature Communications The authors use 3D live imaging on micro-dissected human hair follicle segments cultured ex vivo to follow cellular migration patterns with single cell resolution. They provide evidence suggesting an ...

So proud to share this beautiful work developed in collaboration with @lorealfrance.bsky.social
Using 3D imaging at an outstanding level of resolution, we have uncovered the intricate cellular dynamics of human hair follicles - and the movies are stunning!
More details here: tinyurl.com/4vrywf3z

An amazing preprint on molecular evolution (p63-Notch) of Epithelial Multilayering

Cross-organ (14 in🐭), Cross-species (7🪰🐟x2🐸🐥🐭👤) single-cell transcriptomics

p63+Jag2+ basal signal sendor▶️ p63-Hes1+ suprabasal receivers🐭

bioRxiv 2025
www.biorxiv.org/content/10.1...

Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission @natcomms.nature.com
www.nature.com/articles/s41...

I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...

Proximal proteomics reveals a landscape of human nuclear condensates - Nature Cell Biology Li, Li, Wu et al. use a proteomics approach, PhastID to identify protein components of nuclear condensates (NCs). They reveal crosstalk between NCs, the dynamics of condensate components and identify ...

www.nature.com/articles/s41...

The latest in my favorite love triangle:
Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du

Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity Acute stress causes immediate hair follicle necrosis and hair loss via sympathetic nerves, which in turn activates and expands autoreactive CD8⁺ T cells targeting hair follicles. Thus, a single stress event not only causes immediate tissue damage but also predisposes the tissue to future autoimmune attack.

Now online! Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis Members of the interleukin-17 family are associated with tumor progression in various settings. Denk et al. find that, in colorectal cancer, IL-17RA switches from tumor promotion during early tumorige...

Finally announcing our new study in @cp-immunity.bsky.social!

We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!

#immunosky #cancer #immunology @loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social

Read here🧵👇:
tinylink.net/OS41F

Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export?
Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

Our latest paper has just been published in Cell!

doi.org/10.1016/j.ce...

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.

Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.

Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6

www.biorxiv.org/content/10.1...