IFI16 senses and protects stalled replication forks Gamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DNA damage. Furthermore, IFI16 exhibits dual functionality during replication stress by protecting stalled, remodeled replication forks from nucleolytic degradation.

Online Now: IFI16 senses and protects stalled replication forks Online now:

IFI16 senses and protects stalled replication forks Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…

New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks.

www.sciencedirect.com/science/arti...

Whaaaaa? Noooooo

Great to see it out. Epic study.

Hab SoSlI' Quch!

Wake up by RATM.
Wake up bomb by REM
Wake up bh Funkadelic
Wham, obviously

5 - damn!

Tis pretty cool!

I feel like I'd miss the soul crushing.

Congratulations!

Last 3 days to apply for this post. Deadline 27/10/25

Cheers Sarah!

Thanks Pietro!

A nuclease-driven mechanism of post-replicative ssDNA gap suppression. The persistence of post-replicative ssDNA gaps following PRIMPOL-mediated replication repriming is linked to chemosensitivity, and in all models reported to date the nuclease MRE11 has been implicated...

New preprint from the lab for any DNA repair or replication stress geeks out there!

www.biorxiv.org/content/10.1...

Postdoctoral Fellow - Costa Lab Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Done lefkas, parga, Crete and Athens riviera a few times. All pretty fab. Corfu definitely on the list...

Was looking at Malta, but have gone for Xmas in Iceland - but different:)

Pre-print alert! Together with @stapleslab.bsky.social and @cejkalab.bsky.social we find that IFI16 binds to stalled replication forks where it acts as innate immune sensor for replication stress, and protects the nascent DNA from degradation. 👇👇

"give mouse guts now pls"

Cheers Pietro

IFI16 senses and protects stalled replication forks Replication stress is a key driver of DNA damage and genome instability. Replication stress-induced fork remodelling generates a new DNA end that is vulnerable to the action of nucleases, and which is...

New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social

www.biorxiv.org/content/10.1...

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

Nice work - our data in a totally different model suggests the same

Pls repost. Postdoc role on post-replicative ssDNA gap processing. Interesting models that should float replication aficionados boats. DM or c.staples@bangor.ac.uk for info. Until Dec26 but will strive for funding to provide continuity.
Fantastic place to live+work
www.jobs.ac.uk/job/DMG682/r...

jobs.bangor.ac.uk/details.php....

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info