UPENN_ITMAT

Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

Age-related inhibition of #GutBrainSignaling reduces hippocampal activity and impairs #MemoryEncoding doi.org/10.1038/s415... #Aging #Microbiome #TranslationalScience

Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer - Nature Biomedical Engineering A pan-haematologic cancer approach, involving analysis of data from 256 patients across 5 cancer types and 13 clinical trials, revealed predictive biomarkers for understanding the response or non-resp...

Leveraging #ComputationalBiology at scale to individualize #Immunotherapy: www.nature.com/articles/s41... @JoeFraietta @carlhjune #CARTcelltherapy #CellTherapy #CARTCell #TranslationalScience

Charting a course toward meaningful #AIliteracy in #PediatricCaregiving doi.org/10.1542/peds... #AI #MediaLiteracy #GenerativeArtificialIntelligence #TranslationalScience

Optimizing #CRISPR for #FunctionalGenomics in patient-derived #Xenograft and primary #AcuteMyeloidLeukemia w/ diverse #PathogenicMutations doi.org/10.1016/j.mo... @junwei_s #AML #TranslationalScience

Interbreeding between Neanderthals and modern humans was strongly sex biased Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...

Novel insight into where the #Neanderthal DNA that persists in people today comes from: www.science.org/doi/10.1126/... @sarahtishkoff.bsky.social #PaleoGenomics #EvolutionaryBiology #TranslationalScience

Reimagining scientific communication using art as a tool for the next generation of translational scientists doi.org/10.1017/cts.... @carstenskarke.bsky.social #ITMATEd #ScienceCommunication #SciComm #SciArt #WorkforceDevelopment #TranslationalScience

#Tryptophan supplementation may attenuate #Naproxen adverse effects and widen its #TherapeuticIndex www.nature.com/articles/s41... @FitzGerald__Lab #Pharmacology #DrugMechanism #DrugSafety #TranslationalScience

Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.

#Drosophila model updates our understanding of brain–periphery interactions: www.nature.com/articles/s41... @amitaseh #BrainHealth #Neurobiology #SleepResearch #Neuroscience #TranslationalScience

Revising the model for #SurfactantProteinC maturation: doi.org/10.1016/j.jb... #PulmonaryFibrosis #CellBiology #ProteinTrafficking #AT2Cells #LungDisease #TranslationalScience

#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience

#1 in Medical Breakthroughs: Seven of the top 20 papers honored by the Clinical Research Forum (CRF) are from Penn @CRForumUS #TranslationalScience

#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience

Can #BrownAdipose tissue be activated for therapeutic benefit in #MetabolicDisease? Possibly by harnessing cell-autonomous pathways: doi.org/10.1016/j.mo... @BaurLab #TranslationalScience

Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy This cohort study using data from the Sarcomeric Human Cardiomyopathy Registry determines the association of area-based social determinants of health with clinical outcomes in patients with hypertroph...

How your neighborhood modulates genetically determined disease risk jamanetwork.com/journals/jam... #HypertrophicCardiomyopathy #HCM #TranslationalScience

Regulating acetyl-CoA levels through Acetyl-CoA Synthetase 2 emerges as potential safeguard for #CognitiveFunction www.pnas.org/doi/10.1073/... #ACSS2 #Neurodegeneration #Tauopathy #TranslationalScience

Need to consider pharmacokinetic & -dynamic properties & patient-specific risk factors when comparing the cardiovascular risk associated with specific #NSAIDs www.ahajournals.org/doi/epub/10.... @ktheken @TiloGrosser #TranslationalScience

Happy New Year from ITMAT!

Characterizing individual contributions of the different components of #mRNA #vaccine to mount #ImmuneResponse doi.org/10.1016/j.ce... #mRNAvaccine @Loccilab #TranslationalScience

#TargetedGeneTherapy for partial restoration of #MitochondrialFunction and protection against #DilatedCardiomyopathy www.nature.com/articles/s41... #MitochondrialCardiomyopathy #CardiacFunction #PGC1α #TranslationalScience

Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage | Circulation BACKGROUND: Black people bear a disproportionate burden of hypertension and hypertension-attributed chronic kidney disease. A role of apolipoprotein L1 (APOL1) risk variants (RVs; G1 and G2) in these ...

Defining the role of #ApolipoproteinL1 (#APOL1) #RiskVariants on #BloodPressure www.ahajournals.org/doi/10.1161/... @ksusztak.bsky.social‬ #HealthEquity #KidneyHealth #TranslationalScience

Scaling personalized gene-editing therapy into a future of “interventional genetics” through “umbrella of umbrellas” master protocol clinical trial approaches doi.org/10.1016/j.aj... @ahrensnicklas.bsky.social @kiranmusunuru.bsky.social #CRISPR #TranslationalScience

Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration - Nature Metabolism Modulating mitochondrial NAD+ levels by changing the expression of the mitochondrial NAD+ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than cytosolic or nuclear, NAD+...

Honing in on characterizing biological implications of the #hepatic #Mitochondria NAD+ pool www.nature.com/articles/s42... #OrganRegeneration #MembraneTransporter #TranslationalScience

#CARTCell based hyperlocalized targeting of #InflammatoryPathways involved in development of #AtheroscleroticPlaque doi.org/10.1161/CIRC... @IAmDrDex @PoseyLab #CellTherapy #ImmunoTherapy #Atherosclerosis #TranslationalScience

Wishing you a joyful and restful Thanksgiving!

Ilucidating the critical interplay between environmental timing cues and endogenous #CircadianRhythms for #Influenza outcomes www.jci.org/articles/vie... @sengupta_shaon #ImmuneResponse #Chronobiology #CircadianMedicine #TranslationalScience

Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death - Scientific Reports Scientific Reports - Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death

#ICU patients w/ reverse #BloodPressure dipping at 40% higher risk to be diagnosed w/ #Delirium & 13% increased #RiskOfDeath www.nature.com/articles/s41... @Nadimeljamal @carstenskarke.bsky.social #CriticalCare #BiologicalRhythm #Cognition #TranslationalScience

How Patients With Amyotrophic Lateral Sclerosis Perceive Respiratory Interventions | Neurology Clinical Practice Background and ObjectivesAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that commonly leads to respiratory failure. Early respiratory interventions that may improve symptoms and ou...

Determinants of receptiveness to respiratory care in patients w/ diagnosis of #AmyotrophicLateralSclerosis www.neurology.org/doi/10.1212/... #ALS #ALSResearch #LouGehrigDisease #ImplementationScience #TranslationalScience

Remote, Automated Gamification and Community-Based Physical Activity in Parkinson Disease This nonrandomized clinical trial tests the efficacy of a remote, automated gamification intervention for increasing daily steps in people with Parkinson disease.

Remote incentivized trialing raises #PhysicalActivity levels by ≈30% in #ParkinsonsDisease jamanetwork.com/journals/jam... #Parkinsons #TranslationalScience