#GI25 highlights #CommunityOnc:
1. #SCIENCE: Adv Eso SCC
2. #ESOPEC publication (Eso/GEJ/Ga)
3. Chemo in resectable Panc Ca
4. #StarterNET: GEP-NET
5. #CM8HW: dMMR/MSI-H mCRC
6. #BREAKWATER: BRAFV600E mCRC
7. ctDNA: #BESPOKE + SWOG80702
#OncSky #gism @ascocancer.bsky.social
1/8
🔥NRG GI-007🔥
LA-Esophagus Carcinoma
🔍 dCRT (50.4 Gy/28 fx carbo/taxol) + endoscopically injected oncolytic virus OBP-301
✅💯 cCR rate❗️
✅Comparatively favorable AE profile
👏🏽👏🏽 Brilliant work and looking forward to future study!!
#GI25 @ascocancer.bsky.social
🚨Pooled CAO/ARO/AIO-12 and OPRA Rectal trials🚨
Study suggests that selective WW compared with planned surgery offers:
✅ Comparable OS and DFS!!
🔥 Supports WW as a highly appropriate, and potentially preferable, option for patients with cCR after TNT‼️
#GI25 #CRC @ascocancer.bsky.social
@oncbrothers.bsky.social
@ascocancer.bsky.social
@jrgralow.bsky.social
@mandyda.bsky.social
@heloisasoares.bsky.social
@oncoalert.bsky.social
@weoncologists.bsky.social
🔥🔥🔥BREAKWATER🔥🔥🔥
BRAF V600E mut #CRC
SOC (FOLFOX) +/- encorafenib + cetuximab
EC + FOLFOX shows:
✅⬆️ORR
✅Strong suggestion of ⬆️OS
🚨EC + FOLFOX is a new SOC‼️
Pub available: idp.nature.com/authorize?re...
#GI25 @ascocancer.bsky.social
@oncbrothers.bsky.social
@ascocancer.bsky.social
@jrgralow.bsky.social
@mandyda.bsky.social
@heloisasoares.bsky.social
@oncoalert.bsky.social
@weoncologists.bsky.social
@oncbrothers.bsky.social
@ascocancer.bsky.social
@jrgralow.bsky.social
@mandyda.bsky.social
@krishanjethwa.bsky.social
@heloisasoares.bsky.social
@oncoalert.bsky.social
@weoncologists.bsky.social
🚨🚨CheckMate 8HW🚨🚨
🔥NEW SOC🔥
dMMR/MSI-H mCRC
Ph3 RCT 🔍 Nivo vs Ipi + Nivo
Ipi + Nivo offers:
✅⬆️ Early and sustained PFS
✅favorable safety profile
Pub available: www.thelancet.com/journals/lan...
#GI25 #crc @ascocancer.bsky.social
🚨SCIENCE Ph3 RCT🚨
🔥Check this one out!🔥
cT2-4N0-3, T1N2-3 Eso SCC
1️⃣neo Carbo + nab Paclitaxel + Sintilimab
2️⃣nCRT (41.4/23) w/ Carbo-taxol + Sintilimab
3️⃣nCRT
✅⬆️⬆️pCR CRT vs chemo (only 13% with chemo)
✅Sintilimab + CRT ⬆️ pCR (47%➡️60%) without added AEs
#GI25 @ascopost.bsky.social
