Plus got to do some advertising for the new lab 👀 👀
#strphy26
19.02.2026 05:13
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Plus got to do some advertising for the new lab 👀 👀
#strphy26
What a great conference!! Leaving Brisbane inspired about the future of structural phylogenetics!
Thanks again to the organisers @cpuentelelievre.bsky.social @proteinmechanic.bsky.social and Jordan Douglas for an amazing work putting it all together!
Great to chair the session on Virus Evolution at APSPM2026. Thank you to all the speakers for sharing their cool research with us 🦠 Mihnea Bostina, Cinthy Jimenez Silva,
@spyroslytras.bsky.social @jonathonmifsud.bsky.social
#StryPhy26
APSPM2026 - Today's session starts with @claudiaalcar.bsky.social
Charting the protein universe: Deep evolutionary signals in sequence structure space (remote).
She'll present her work on exploring how protein folds emerged and diversified over billions of years.
#StrPhy26 #StrPhy
Amazing talk by @martinsteinegger.bsky.social at the #StructuralPhylogenetics meeting in Brisbane @strphy.bsky.social
The meeting is going to be live for the next 2 days. Excited to see what happens next. #Evolution
Chris Barnes on now! Outpacing RNA viruses. #lorneproteins26 is go 🎆
Looking forward to sharing this method as a hands-on workshop in the upcoming meeting
For a full list of workshop we have: biosig.lab.uq.edu.au/strphy26/wor...
#StrPhy26 #StrPhy #StructuralPhylogenetics #Evolution #Brisbane
Like with the MBE work, DeepRoots introduces a new and much faster way to bootstrap. It achieves this by introducing "Embedding Jitter"—injecting Gaussian noise into the latent space to estimate branch support.
#Phylogenetics #StructuralBiology #Structome #Evolution #StructuralPhylogenetics #StrPhy
The logic behind this is #EmergentLatentBiology #ELB & is now formalized in our new paper in Curr Op in #StructuralBiology arguing that transformers organize biophysics into a "substrate" where biology becomes easily-decodable. www.sciencedirect.com/science/arti...
#Strphy #StructuralPhylogenetics
Enter Structome-DeepRoots which uses high-dimensional embeddings from protein language models to see evolutionary "roots" invisible to geometry alone. It was turned into a web app (still has a lot of bugs 😅). 🔗 biosig.lab.uq.edu.au/structome_de...
#StructuralBiology #StructuralPhylogenetics #StrPhy
Protein structure is more conserved than sequence. Work in 2020 (MBE: academic.oup.com/mbe/article/...), showed 3D data unlocks deeper evolutionary signals. A thought was why not go higher than 3D? 🧵
#Phylogenetics #StructuralBiology #Structome #Evolution #StructuralPhylogenetics #StrPhy
The program is now live. An excellent global lineup of speakers - AUS, NZ, Korea, India, Laos, UK, Switzerland, France, Finland, Germany, Hungary, Japan, Uruguay, Mexico and USA. Browse abstracts. Just 3 weeks left. Super excited.
#StrPhy26 #Science #Evolution #StrPhy #StructuralPhylogenetics
An interesting way to look at encoded structural characters to build alignments and trees downstream. This takes structural phylogenetics one step further in the post-AlphaFold era.
#Evolution #Science #StrPhy
On Confidence Assessment in Structure-Aware Alignments
doi.org/10.1093/gbe/...
Phylomania logo
Had an amazing three days hanging out with brilliant minds at #Phylomania 2025. Amazing mathematicians tackling amazing challenges. #Science #Phylogenetics
We have had some amazing abstracts submitted to the free
@official-smbe.bsky.social APSPM meeting. To help you make up your mind, here is a sneak peek. Join for what will be an amazing meeting. biosig.lab.uq.edu.au/strphy26/sneakpeek/ . #StrPhy26 @strphy.bsky.social #Evolution #Science
Taking a break from the usual #Phylogenetic exploration to spend a little time on the #Quantum computing side of my work.
Hanging out with #Queensland Quantum community at the
Qx | Advanced Technologies for Life and Planet.
We are excited to announce APSPM 2026 - the SMBE Australasian Protein Structural Phylogenetics Meeting!
🗓️ 15-18 Feb. 2026
🌏 Brisbane, Australia
🔗 biosig.lab.uq.edu.au/strphy26/
📄 Abstract submission: 28.11.2025
✈️ Travel grant application: 28.11.2025
✏️ Registration: 15.01.2026
#StrPhy26
Announcing @official-smbe.bsky.social Australasian Protein Structural Phylogenetics Meeting in Brisbane Feb 15-18, 2026. FREE registration. Join for exciting talks & workshops at the interface of protein structure, function & evolution. biosig.lab.uq.edu.au/strphy26/ #StrPhy26 @strphy.bsky.social
Attending a fascinating talk by
Prof Begona Heras on “Structural insights into the function and inhibition of bacterial virulence proteins. “
Looking for overlaps with methods we are putting together in the Structural Phylogenetics space. #StrPhy #StructuralPhylogenetics @strphy.bsky.social
We’ve set up a dedicated Bluesky space for structural phylogenetics: @strphy.bsky.social. Follow for community updates.
#StrPhy #StructuralPhylogenetics
Special Section in GBE: Structural Phylogenetics
Here we showcase novel work on how 3D protein structures can reshape evolutionary biology, from methods to applications.
More papers coming out soon!
@genomebiolevol.bsky.social @proteinmechanic.bsky.social
academic.oup.com/gbe/search-r...
Third Era of Phylogenetics!
1️⃣ Era 1: Morphology 🦴
2️⃣ Era 2: Sequences 🧬
3️⃣ Era 3: 3D Structures ⚛️
Solving deep evolutionary puzzles like never before. Our new review in GBE explores what's next in #phylogenetics
academic.oup.com/gbe/article/...
#structuralbiology #evolution #AlphaFold #SciSky
Quantome: A Quantum Surrogate Model for Biophysical Landscapes https://www.biorxiv.org/content/10.1101/2025.08.06.668871v1
Quantome: A Quantum Surrogate Model for Biophysical Landscapes https://www.biorxiv.org/content/10.1101/2025.08.06.668871v1
Playing around with quantum-styled math on trivial biological problems before tackling the really hard questions. Initial signs are good, with the math behaving as expected. Next leg would be using a non-trivial dataset like missense variants.
Tagetes lemmonii, also known as Lemmon’s marigold (or mountain marigold according to Google's Brisbane result) is shown against a blurred background (bokeh).
Within Tagetes lemmonii, (Lemmon’s marigold) are defence molecules called thiophenes which become highly toxic when exposed to sunlight, damaging pests at the cellular level. An elegant example of how plants weaponize light to survive.
#Brisbane #nature #nikon #naturephotography #SciComm
If you do deep evolutionary analysis - structure-aware characters can help. To ensure correct alignments - give it a try: biosig.lab.uq.edu.au/structome_al...
If you would like any features added, drop a message and will give it a shot.
#Science #Evolution #MolecularEvolution #DeepEvolution
Explore it here: biosig.lab.uq.edu.au/structome_al...
Free to use, no login required.
Feedback welcome — especially if you're working on deep evolutionary comparisons.
🕰️ Let these structure-aware sequence alignments reveal a distant past that amino acid sequences alone couldn’t reach.
Using pairwise structure-aware character substitution scores across your proteins, the app computes per-column confidence, maps it to B-factors, and visualizes it in Mol*. You can spot conserved cores.
But structure-aware alignments can mislead if divergent folds cause misalignments. That’s where Structome-AlignViewer comes in — it helps you evaluate how reliable each alignment column is, and where structural consistency holds up.