Biophysical Reports

Beneath the Hair Bundles: Imaging Activity within the Hair Cell Soma Our group focuses on the fundamental physics that enables the auditory system to detect extremely small, rapid mechanical movements. We study how it senses sub‑nanometer deflections, how it preserves ...

Read about the cover art for the newly released issue of Biophysical Reports on the BPS Blog: www.biophysics.org/blog/beneath...

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Computational Perspectives on Tubulin E-hook Structure and Mechanisms E-hooks, or the C-terminal tails of tubulin, mediate interactions between microtubules and associated proteins. Despite their functional importance in cellular and physiological processes, their…

Check out an article from our most read list: "Computational Perspectives on Tubulin E-hook Structure and Mechanisms" (Alexander C. Bromley and Dana N. Reinemann)

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Sequence and Topology Shape the Conformational Dynamics of Circular DNA Molecules In this work, we used coarse-grained molecular dynamics simulations to characterize the response of circular DNA molecules to mechanical stress—specifically, how the latter influences the occurrence…

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BPS2025 - Optical imaging of sub-cellular fluctuations within hair cells Hair cells of the auditory and vestibular systems are capable of detecting sub-nanometer deflections caused by air-borne or ground-borne vibrations. In certain species and under specific conditions, t...

Online now! Optical imaging of sub-cellular fluctuations within hair cells. Martín A. Toderi, Dzmitry Vaido, and Dolores Bozovic. www.cell.com/biophysj/ful...

Toward measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime Membrane potential (MP) changes can provide a simple readout of bacterial functional and metabolic state or stress levels. While several optical methods exist for measuring fast changes in MP in…

Check out an article from our most read list: "Toward measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime" (Debjit Roy et. al.)

Single Cell Vibration Analysis for Potential Diagnostic Applications Vibrational frequency profiling (VFP) using optical tweezers (OT) has emerged as a promising technique to characterize single cell behavior for diagnostic applications. These applications include…

Online now! Single Cell Vibration Analysis for Potential Diagnostic Applications. Jared J. Topham, Ali Al-Khaz’Aly, Salim Ghandorah, Tvara Parikh, Farshad Farshidfar, and Matthias Amrein.

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Mimicking oxidative damage in γS-crystallin with site-specific incorporation of 5-hydroxytryptophan The human eye lens plays an essential role in vision by focusing light onto the retina. This transparent tissue consists of densely packed crystallin proteins that exhibit remarkable solu- bility desp...

Online now! Mimicking oxidative damage in γS-crystallin with site-specific incorporation of 5-hydroxytryptophan. Yeonseong Seo, Zane G. Long, Tsoler K. Demerdjian, Acts A. Avenido, Carter T Butts, and Rachel W. Martin. www.cell.com/biophysrepor...

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Sequence and Topology Shape the Conformational Dynamics of Circular DNA Molecules In this work, we used coarse-grained molecular dynamics simulations to characterize the response of circular DNA molecules to mechanical stress—specifically, how the latter influences the occurrence…

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A piperidinyl amide compound enhances Ca2+ signaling in cardiomyocytes by increasing activity of Ca2+ pump In adult cardiomyocytes, the type 2a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a) plays a vital role in intracellular Ca2+ regulation. Reduced SERCA2a function has been associated with decreased ...

Online now! A piperidinyl amide compound enhances Ca2+ signaling in cardiomyocytes by increasing activity of Ca2+ pump. Elisa Bovo, Roman Nikolaienko, Samantha L. Yuen, Catherine A. Makarewich, Marzena Brinkmann, David D. Thomas, Robyn T. Rebbeck, and Aleksey V. Zima. www.cell.com/biophysrepor...

Computational Perspectives on Tubulin E-hook Structure and Mechanisms E-hooks, or the C-terminal tails of tubulin, mediate interactions between microtubules and associated proteins. Despite their functional importance in cellular and physiological processes, their struc...

Online now! Computational Perspectives on Tubulin E-hook Structure and Mechanisms. Alexander C. Bromley and Dana N. Reinemann. www.cell.com/biophysrepor...

Effect of Hemodynamic on Clot Formation and Flow Cessation in Patient-Specific Coronary Bifurcations Hemostasis prevents bleeding by forming clots, though disruptions can cause insufficient or excessive clotting. Shear stress is a critical factor influencing the normal function of the blood and can s...

Online now! Effect of Hemodynamic on Clot Formation and Flow Cessation in Patient-Specific Coronary Bifurcations. Mohammad Rezaei and Bahar Firoozabadi. www.cell.com/biophysrepor...

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