We make molecules!

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Microbial chocolatiers of fine flavour 🍫

by Pablo Cruz-Morales

www.nature.com/articles/s41...

Climate change is stressing our forests, fungal allies may turn into pathogens. Are we ready for this?
Don’t miss this call to action for new model organisms & functional studies in forest pathogens. By Anne Oostlander and col. at TU Braunschweig and FABI
nph.onlinelibrary.wiley.com/doi/full/10....

Data release in the next days: 87 genomes, >5000 BGC annotations and >400 mass spectra, hoping to help others working in SUSTAINABLE AGRICULTURE. Check our preprint for details

Our biosynthetic survey of biocontrol fungi is out now!
lnkd.in/dJbyis5f
Dr. Ana Calheiros de Carvalho combined analytical chemistry, post-genomics and Synbio to catalog and discover lots of natural products. Data release in the next few days:

Check our preprint for details ⚗️ 🍄 🥰 🌽

Our PhD student Adrian Gadar López and the Black Yeast Natural Products team made fungal PKS Heterologous Expression easy! Check out the preprint.
www.researchsquare.com/article/rs-6...
#wemakemolecules #blackyeast #NNF_BRIGHT

getphylo: rapid and automatic generation of multi-locus phylogenetic trees - BMC Bioinformatics Background The increasing amount of genomic data calls for tools that can create genome-scale phylogenies quickly and efficiently. Existing tools rely on large reference databases or require lengthy d...

getphylo is finally official! Build phylogenetic trees directly from genbank files - at breakneck speed! I'd like to thank everyone who provided feedback and encourage you to continue. Improving getphylo doesn't stop now the paper is out!
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bmcbioinformatics.biomedcentral.com/articles/10....

Have a look at our latest study on large-scale #Streptomyces BGC mining / pangenome analysis: genomebiology.biomedcentral.com/articles/10....

Fungi oysters: Inside the Danish lab producing next alternative food At a Technical University of Denmark lab, researchers are exploring the potential for fungi to be used as meat and seafood replacements.

Feeding 9 billion people will take lots of creativity and the best scientists. Check how Dr. Loes van Dam is working on new fungal foods are DTU biosustain. #DTU_BRIGHT
www.euronews.com/health/2025/...

StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes Streptomycetes hold immense potential for discovering novel bioactive molecules for applications in medicine or sustainable agriculture. However, high-throughput exploration is hampered by the current...

Are you working with #streptomycetes? Then you may be interested in trying our new #StreptoCAD platform: StreptoCAD is an open-source software
toolbox automating genome engineering
workflows in streptomycetes. www.biorxiv.org/content/10.1...

Development of a molecular genetics and cell biology toolbox for the filamentous fungus Diplodia sapinea Diplodia sapinea (Fr.) Fuckel is a widespread fungal pathogen affecting conifers worldwide. Infections can lead to severe symptoms, such as shoot blight, canker, tree death, or blue stain in harvested...

Diplodia sapinea a pine endophyte lives a harmless life until the tree is dying... Climate change is stressing trees and turning harmless fungi into pathogens. How? It is not clear, new tools to study them are needed, check work by Anne Oostlander of TU Braunschweig journals.plos.org/plosone/arti...

Happy new year!!

The perfect molecule doesn't exist... Until Dr Ana Calheiros de Carvalho find it with her metabologenomics workflow for biocontrol molecules! Check it out poster #81 #NP2025 San Diego #DTU_BRIGHT

N.R.P.S. will stand for No Resistant Pest will Stand after Dr Carolina Cano-Prieto engineer them with her SynBio tools. Poster 38 #NP2025 #DTU_BRIGHT #sustainableagriculture

Saccharomyces Fans are scared of this black yeast! Check out how our PhD student Adrian Gadar-Lopez and his black yeast makes bioproducts like gangbusters. Poster #37 #NP2025 #DTU_BRIGHT #clickbait

Do you dream of making polyketides advanced materials with polyketide synthases? Check our PhD student Sidharth Jayachandran's poster at #NP2025 San Diego #OMG #DTU_BRIGHT

The #antiSMASH beta is now live on the website. There’s some minor updates and maybe a bug fix out two separating us from what will be in the final release. Please let up know if you run into any bugs.
Thanks to all the contributors for getting us past 100 detection rules and all the other updates

StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes https://www.biorxiv.org/content/10.1101/2024.12.19.629370v1

ActinoMation: a literate programming approach for medium-throughput robotic conjugation of Streptomyces spp. The genus Streptomyces are valuable producers of antibiotics and other pharmaceutically important bioactive compounds. Advances in molecular engineering tools, such as CRISPR, has provided some access...

This time a little different story from our lab @dtu.dk: here we present #ActinoMation, a literate programming workflow to automate #Streptomyces conjugation on Opentron robots. www.biorxiv.org/content/10.1...

A conserved bacterial genetic basis for commensal-host specificity Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...

Check out this fantastic work on how Drosophila comensal bacteria evolved host-specific adhesins to hang to their gut. by Dr. Karina GUTierrez. Of Carnegie @karinagtzga by the power of functional genomics and live imaging! www.science.org/doi/10.1126/... #f

Today was a great day at YNP, DTU biosustain. we hosted a seminar by Dr. Manu Villalobos our winter guest. He showed us his systems biology tools for filamentous fungi and speed the Trichoderma gospel! #fungi #biocontrol #sustainabity