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Randy Ellis

@randalljellis

Host of Metascience Matters; Data Scientist https://youtube.com/@metasciencematters https://open.spotify.com/show/7coSExbjL2LnlBZh89BDZG?si=V4qEsyWzT4KQ1kCiNbBcIQ

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22.09.2023
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Latest posts by Randy Ellis @randalljellis

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Forensic Metascience, the GRIM test, and technology for checking papers | Metascience Matters #4 Spotify video

Also available on Spotify: open.spotify.com/episode/0zH0...

04.03.2026 02:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Forensic Metascience, the GRIM test, and technology for checking papers | Metascience Matters #4
Forensic Metascience, the GRIM test, and technology for checking papers | Metascience Matters #4 YouTube video by Metascience Matters

Here's my conversation with @jamesheathers.bsky.social, Founder/Director of the Medical Evidence Project, on Metascience Matters: www.youtube.com/watch?v=QH87...

We discussed his book on Forensic Metascience, the story behind the GRIM test, how technology can enable metascience, and other topics.

04.03.2026 01:36 πŸ‘ 8 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0
Maximum Likelihood Estimation (MLE) with Examples
Maximum Likelihood Estimation (MLE) with Examples YouTube video by Steve Brunton

Steve Brunton’s videos are good youtu.be/rCdxlN6Ph14?...

03.03.2026 20:29 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Building a Publishing Model for Replication: Q&A with the Senior Editors of Replication Research COS spoke with the senior editors of Replication Researchβ€”a community-led Diamond Open Access journal that supports reproduction and replication studies.

Replication Research (R2), a πŸ†• community-led Diamond OA journal, makes replication studies more discoverable, publishable & rigorously evaluatedβ€”without subscription barriers or author fees. Ahead of #LoveReplicationsWeek, R2's senior editors shared their vision in our Q&A:

27.02.2026 13:54 πŸ‘ 11 πŸ” 8 πŸ’¬ 0 πŸ“Œ 1
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Nanoscience is latest discipline to embrace large-scale replication efforts A European project calls for help to verify whether carbon quantum dots are really able to sense chemicals in cells.

Wonderful to see this replication effort in the physical sciences using the models of many labs, preregistration, and transparency that have benefitted other fields.

And, an investment of $9.5 million to do it!

www.nature.com/articles/d41...

22.02.2026 13:45 πŸ‘ 37 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0
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Here's what a Cohen's d = 22 looks like. Totally normal. See it all the time in my own data...

13.02.2026 17:48 πŸ‘ 11 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

Today in that-didn't-happen: Cohen's d = 22.

Williams et al. (2014) has 145 citations, putting it in top 1% of most cited psych articles.

It is a load-bearing publication in its area, despite having impossible results.

pubpeer.com/publications...

13.02.2026 16:51 πŸ‘ 42 πŸ” 9 πŸ’¬ 4 πŸ“Œ 0
It must be very hard to publish null results
Publication practices in the social sciences act as a filter that favors statistically significant results over null findings. While the problem of selection on significance (SoS) is well-known in theory, it has been difficult to measure its scope empirically, and it has been challenging to determine how selection varies across contexts. In this article, we use large language models to extract granular and validated data on about 100,000 articles published in over 150 political science journals from 2010 to 2024. We show that fewer than 2% of articles that rely on statistical methods report null-only findings in their abstracts, while over 90% of papers highlight significant results. To put these findings in perspective, we develop and calibrate a simple model of publication bias. Across a range of plausible assumptions, we find that statistically significant results are estimated to be one to two orders of magnitude more likely to enter the published record than null results. Leveraging metadata extracted from individual articles, we show that the pattern of strong SoS holds across subfields, journals, methods, and time periods. However, a few factors such as pre-registration and randomized experiments correlate with greater acceptance of null results. We conclude by discussing implications for the field and the potential of our new dataset for investigating other questions about political science.

It must be very hard to publish null results Publication practices in the social sciences act as a filter that favors statistically significant results over null findings. While the problem of selection on significance (SoS) is well-known in theory, it has been difficult to measure its scope empirically, and it has been challenging to determine how selection varies across contexts. In this article, we use large language models to extract granular and validated data on about 100,000 articles published in over 150 political science journals from 2010 to 2024. We show that fewer than 2% of articles that rely on statistical methods report null-only findings in their abstracts, while over 90% of papers highlight significant results. To put these findings in perspective, we develop and calibrate a simple model of publication bias. Across a range of plausible assumptions, we find that statistically significant results are estimated to be one to two orders of magnitude more likely to enter the published record than null results. Leveraging metadata extracted from individual articles, we show that the pattern of strong SoS holds across subfields, journals, methods, and time periods. However, a few factors such as pre-registration and randomized experiments correlate with greater acceptance of null results. We conclude by discussing implications for the field and the potential of our new dataset for investigating other questions about political science.

I have a new paper. We look at ~all stats articles in political science post-2010 & show that 94% have abstracts that claim to reject a null. Only 2% present only null results. This is hard to explain unless the research process has a filter that only lets rejections through.

11.02.2026 17:00 πŸ‘ 643 πŸ” 223 πŸ’¬ 30 πŸ“Œ 51
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Without publication bias, we might not need many replications. With publication bias, 20% to 40% might be justified (but of course, extremely dependent on the assumptions in the simulations!). If the field is a mess, we need a lot of replication studies to clean up!

11.02.2026 08:40 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

My colleague Krist Vaessen wrote a new book: β€œNeomania: How our obsession with innovation is failing science, and how to restore trust”. It's a great analysis how the drive for novelty hinders reliable scientific progress. Open Access, so read it here: books.openbookpublishers.com/10.11647/obp...

09.02.2026 15:42 πŸ‘ 13 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
300+ retractions, image manipulation, and why science should be boring | Metascience Matters #3
300+ retractions, image manipulation, and why science should be boring | Metascience Matters #3 YouTube video by Metascience Matters

Here's my conversation with Mu Yang on Metascience Matters: www.youtube.com/watch?v=E2EK...

We discussed her work as a scientific sleuth, academic incentives for positive data, individual cases she has pursued, and why she loves being a sleuth.

Also on Spotify: open.spotify.com/episode/16R6...

08.02.2026 19:10 πŸ‘ 14 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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New submission format at SBE:
β€œReplications as Registered Reports”

link.springer.com/journal/1118...

You can get "in-principle acceptance" before data collection even begins; final paper gets published regardless the results, if the study is conducted rigorously.

#EconSky

29.01.2026 05:54 πŸ‘ 25 πŸ” 17 πŸ’¬ 1 πŸ“Œ 4

Call for metascience grants has a focus on three areas:

πŸ”ΈοΈ The impact of artificial intelligence on scientific practice and the research landscape

πŸ”ΈοΈ The effective design and leadership of research organisations

πŸ”ΈοΈ Scientometrics approaches to understanding research excellence, efficiency and equity

27.01.2026 17:15 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Some discussion about this in a conversation I’ll be releasing in early March, thanks Rasu!

27.01.2026 16:23 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
Metascience Matters I'm Randy Ellis, a computational biologist and neuroscientist who cares about metascience, reproducibility, and rigor in science. I started Metascience Matters because I believe science communication ...

YouTube: youtube.com/@metascience...
Spotify: open.spotify.com/show/7coSExb...
Apple: podcasts.apple.com/us/podcast/m...
iHeart: www.iheart.com/podcast/269-...

23.01.2026 12:58 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Exposomics, Vibration-of-Effects, and the Future of AI in Health | Metascience Matters #1
Exposomics, Vibration-of-Effects, and the Future of AI in Health | Metascience Matters #1 YouTube video by Metascience Matters

I started a podcast! Metascience Matters features conversations with metascientists.

Two episodes are live:

Chirag Patel on Exposomics, and Vibration of Effects: youtu.be/RT2nypyb-iM?...

@floriannaudet.bsky.social on Clinical Trials, Registered Reports, and Psychiatry: youtu.be/fn4qtnc99Xo?...

23.01.2026 12:49 πŸ‘ 20 πŸ” 7 πŸ’¬ 2 πŸ“Œ 0
This paper in Management Science has been cited more than 6,000 times. Wall Street executives, top government officials, and even a former U.S. Vice President have all referenced it. It’s fatally fl...

This paper in Management Science has been cited more than 6,000 times. Wall Street execs, top govt officials, and even a former U.S. Vice President have all referenced it. It’s fatally flawed, and the scholarly community refuses to do anything about it.
statmodeling.stat.columbia.edu/2026/01/22/a...

22.01.2026 14:31 πŸ‘ 28 πŸ” 13 πŸ’¬ 0 πŸ“Œ 2

Congratulations!

19.01.2026 13:55 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Statistical Rethinking 2026 - Lecture B01 - Multilevel Models
Statistical Rethinking 2026 - Lecture B01 - Multilevel Models YouTube video by Richard McElreath

Statistical Rethinking 2026 Lecture B01 Multilevel Models is online. This is the first lecture of the "experienced" section, in which we start with multilevel models and venture into vast covariance spaces. Full lecture list still here: github.com/rmcelreath/s...

09.01.2026 10:34 πŸ‘ 97 πŸ” 17 πŸ’¬ 0 πŸ“Œ 1

With some trepidation, I'm putting this out into the world:
gershmanlab.com/textbook.html
It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class.

My hope is that this will be a living document, continuously improved as I get feedback.

09.01.2026 01:27 πŸ‘ 585 πŸ” 237 πŸ’¬ 16 πŸ“Œ 10
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Data sharing helps avoid β€œsmoking gun” claims of topological milestones Manipulating the topology of electronic bands can realize new states of matter, with possible implications for information technology. A central question is how to tell whether a topological regime ha...

The rarest of sights - a big glossy journal publishing negative replications! Yes, we had to bundle 4 replications into one article AND we had to wait 2 (!!) years in peer review, but here we are:

www.science.org/doi/10.1126/...

08.01.2026 19:21 πŸ‘ 58 πŸ” 19 πŸ’¬ 3 πŸ“Œ 5
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Abandon β€œAbundance” The latest Democratic fad sidelines equality and justice in favor of a focus on cutting red tape. This is not the path forward.

Here’s two, both from the left:

www.currentaffairs.org/news/abandon...

www.levernews.com/abundance-is...

30.12.2025 17:23 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Important. Remember you can’t take science at face value: publication bias is everywhere.

29.12.2025 22:37 πŸ‘ 9 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.

Have had the same surprise, the Errington paper is a milestone not just for the scale of the project, but they also have a separate paper about issues they encountered running the project, hugely instructive for anyone doing replication studies elifesciences.org/articles/67995

19.12.2025 13:46 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Investigating the replicability of preclinical cancer biology A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the...

The other classic ref is Begley and Ellis 2012 (www.nature.com/articles/483... ) which has the same issue, but the ref I always cite now is Errington et al :) elifesciences.org/articles/71601

19.12.2025 13:26 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
# Bayesians are to frequentists as vegetarians are to murderers

I have close friends who do not eat meat, for moral reasons. It's not that they find meat disgusting. In fact, they find it delicious. Instead they regard meat as murder.

And yet we continue to be friends. I myself do not think meat is murder. I regard it in fact as an ordinary and normative part of human society. It's so commonplace. How could it be murder?

This sort of moral incompatibility is commonplace. Vegetarians and vegans have to put up with assholes like me all the time. They are surrounded.

# Bayesians are to frequentists as vegetarians are to murderers I have close friends who do not eat meat, for moral reasons. It's not that they find meat disgusting. In fact, they find it delicious. Instead they regard meat as murder. And yet we continue to be friends. I myself do not think meat is murder. I regard it in fact as an ordinary and normative part of human society. It's so commonplace. How could it be murder? This sort of moral incompatibility is commonplace. Vegetarians and vegans have to put up with assholes like me all the time. They are surrounded.

When I take train journeys, I sometimes write things. Things that I probably shouldn't publish

16.12.2025 17:58 πŸ‘ 75 πŸ” 8 πŸ’¬ 7 πŸ“Œ 2
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To anyone who may have been present at my talk today in which I intimated that you can just, you know, do this: you can just, you know, do this.

11.12.2025 23:58 πŸ‘ 66 πŸ” 16 πŸ’¬ 2 πŸ“Œ 1

Registered reports now

30.11.2025 17:35 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

For many social dilemma's in Science (e.g. the slow uptake of diamond open access journals) stronger top down management is necessary. It won't just happen. If scientists will not create this management themselves, someone is going to create it for us.

24.11.2025 05:47 πŸ‘ 16 πŸ” 4 πŸ’¬ 2 πŸ“Œ 1

For comparison, the profits of four publishers (2.64B) amount to 5.58% of the FY2024 NIH budget. Revenues (7.36B) are *15.52%*. I agree with the authors' perspective that funders, governments, and universities should lead efforts to change this. All journals should be diamond open-access.

13.11.2025 14:21 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0