Olivier Parent

Investigating links between white matter hyperintensities and menopausal status using robust age-correction methods in UK Biobank Wezel, Parent et al. investigated white matter hyperintensity volumes across the menopausal transition in the UK Biobank using strict age-matching procedur

Excited for this new paper in @braincomms.bsky.social by Denise Wezel and @oknox.bsky.social

The association between white matter hyper intensity volume and menopausal status in the UK Biobank
@linasifi.bsky.social @nikigervais.bsky.social @dadarmahsa.bsky.social

academic.oup.com/braincomms/a...

Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis - Alzheimer's Research & Therapy Cerebral small vessel disease (CSVD) is a common neurological condition that contributes to strokes, dementia, disability, and mortality worldwide. We conducted a systematic review and meta-analysis t...

🚨 Hot off the press! 🚨
Our systematic review and meta-analysis on ML+CSVD for dementia diagnosis and prognosis has been published! An international collaboration, featuring @Valerie Lohner
@oparent.bsky.social
@helenagellersen.bsky.social
and many others.

doi.org/10.1186/s131...
@dzne.science

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative e...

After 3 years of "just one more analysis", our work on WMH pathophysiology is finally out!

Building on previous post-mortem findings of non-vascular WMHs, we identified a specific signature of neurodegenerative WMHs in vivo using microstructural MRI and normative modeling

doi.org/10.1101/2025...

Well you were so encouraging every time I had to keep doing it!

... and other bluesky-less co-authors Sophia Osborne, Aurélie Bussy, Manuela Costantino, Jérémie Fouquet, Daniela Quesada, Alexandre Pastor-Bernier, Alfonso Fajardo-Valdez, Ann McQuarrie, Josefina Maranzano, Gabriel A. Devenyi, Christopher J. Steele

Huge thanks to all who have supported and helped this project @zklsmr.bsky.social @alexapb.bsky.social @sylviavilleneuve.bsky.social @dadarmahsa.bsky.social @mallarchak.bsky.social ...

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative e...

After 3 years of "just one more analysis", our work on WMH pathophysiology is finally out!

Building on previous post-mortem findings of non-vascular WMHs, we identified a specific signature of neurodegenerative WMHs in vivo using microstructural MRI and normative modeling

doi.org/10.1101/2025...

Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus - Brain Structure and Function Age-related hippocampal alterations often accompany cognitive decline, a significant risk factor for dementias. Modifiable lifestyle factors may help preserve hippocampal neural tissue and slow neurodegeneration and potentially promote cognition in old age. Here, we sought to identify the relationship between lifestyle and cognition in the context of the hippocampal microstructure across the lifespan. We used data from 494 subjects (36–100 years old) without cognitive impairment from the Human Connectome Project-Ageing study. We estimated hippocampal microstructure using myelin-sensitive (T1w/T2w ratio), inflammation-sensitive (MD) and fibre-sensitive (FA) MRI markers. We identified microstructural-lifestyle/-cognition using non-negative matrix factorization to integrate MRI measures into a multivariate spatial signature of hippocampal microstructure covariance followed by partial least squares analysis. Our results reveal that the preservation of axon density and myelin in regions corresponding to subicular regions and CA1 to CA3 regions are negatively associated with age, and is associated with improved performance in executive function tasks, however, this is also associated with a decreased performance in memory tasks. We also show that microstructure is preserved across the hippocampus when there is normal hearing levels, physical fitness and insulin levels and this is negatively associated with age in the presence of cardiovascular risk factors like high body mass index, blood pressure, triglycerides and blood glucose that are in turn associated with hippocampal neurodegeneration. Taken together, our results suggest that lifestyle factors like normal hearing, physical fitness and normal insulin levels may help preserve hippocampal microstructure which may be useful in maintaining optimum performance on executive function tasks and potentially other modes of cognition.

Delighted to see this wonderful work by Tyler Ageykum out in Brain Structure and Function. Examining the relationship between hippocampal miscrostructure and lifestyle using integrative multivariate techniques.

link.springer.com/article/10.1...

ADPD! I'm excited to present the complete story of my WMH research: "Uncovering spatial pathophysiological patterns of white matter hyperintensities of neurodegenerative origins", including a cool new tractography analysis! Tue April 1st, Hall A, 12:45 #ADPD

Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors Neural alterations, including myelin degeneration and inflammation-related iron burden, may accompany early Alzheimer's disease (AD) pathophysiology. …

New paper led by Aurelie Bussy now out in Neurobiology of Ageing

Here we use non-negative matrix decomposition using morphological and qMRI measures (T1, T2*) to understand the relationship between GM and microstructure across the Alzheimer's spectrum.

www.sciencedirect.com/science/arti...

📢 Habemus preprint 📢
Our systematic review and meta-analysis on ML+vascular neuroimaging for dementia diagnosis and prognosis is out! Fantastic collaboration with @ValerieLohner, @oparent.bsky.social @helenagellersen.bsky.social and many others! Check it out! @dzne.science