Wertheim UF Scripps

Great talk by Ben Shen of @wertheimufscripps.bsky.social today at @leidenscience.bsky.social. He talked about his group's amazing work in natural product discovery. Cool insights into mining massive numbers of genomes and the power of making data openly available(1/2) www.biorxiv.org/content/10.1...

Development of clinically viable non-muscle myosin II small molecule inhibitors

A recent study presents two clinically viable non-muscle myosin II small molecule inhibitors. The molecules exhibit high brain penetration and demonstrate efficacy in preclinical models of methamphetamine use disorder. www.cell.com/cell/abstrac... 🧪 @wertheimufscripps.bsky.social

Dr. Amir Ardeshir and a team in Dr. @mamartins83.bsky.social's lab at @wertheimufscripps.bsky.social used AAV vectors to generate #HIV1 immunity in infant rhesus macaques!

Article: https://go.nature.com/4lwHts2
Episode with discussion: https://bit.ly/4mIESvZ

The lncRNA Gas5 is an activity-responsive scaffold that mediates cAMP-dependent synaptic plasticity RNA-protein complexes coordinated by the long noncoding RNA Gas5 locally support synaptic remodeling.

Latest paper out of the Puthanveettil lab! www.science.org/doi/10.1126/... congrats team!

Mutations Distrupt Touch-Based Learning, Study Finds » The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology » The Wertheim UF Scripps Institute » University of Florida A gene called Syngap1 enables touch-based perception, while certain mutations can lead to mixed signals, a new study finds.

Wertheim UF Scripps Institute professor Gavin Rumbaugh, Ph.D., and staff scientist Thomas Vaissiere, Ph.D., discovered that mutations to the Syngap1 gene can alter touch-based sensory perception. / Photo credit: Scott Wiseman

wertheim.scripps.ufl.edu/2025/03/12/m...

Making history with the Women Chemists Committee Serving the chemical, life science, and laboratory worlds

For #WomensHistoryMonth this March, the American Chemical Society Women Chemists Committee (WCC) will celebrate ACS president Dorothy Phillips and her impressive career in chemistry and leadership. cen.acs.org/acs-news/com...

Hey, #science BlueSky! You need a vacay. Join us for "RNA: From Biology to Drug Discovery" on April 14-15, 2025. This symposium brings together leading global experts in RNA research for new collabs and inspiration. wertheim.scripps.ufl.edu/departments/...

#science #RNA #mRNA #biology

Wertheim UF Scripps Neuroscience Chair Kirill Martemyanov, Ph.D., stands with Nobel Laureate Thomas C. Südhof, M.D., in the institute's Jupiter, Florida auditorium.

His talk focused on "adhesion" molecues that bridge synapses.
A discovery from his group is that these genes can have different functions in neurons depending on how they are spliced, and increased "excitation" is one of the factors that can change gene function. Fascinating!

Nobel Laureate Thomas C. Südhof, M.D. explains a slide showing evidence that the cell adhesion molecule Teneurin 3 acts presynaptically.

Nobel Laureate Thomas C. Südhof, M.D., spoke at the institute today.
🧪Südhof won the Nobel Prize in Physiology or Medicine in 2013 for “discoveries of machinery regulating vesicle traffic, a major transport system in our cells,” and he's a Howard Huges Medical Institute investigator. 🧵1/2

The science you need. 🧪

RNA: From Biology to Drug Discovery 2025: Explore the therapeutic potential of RNA with thought leaders in the field. » RNA: From Biology to Drug Discovery 2025 » The Herbert Wertheim UF Scripps Inst... Hear from world-class RNA scientists who are experts in diverse fields, including computation, biophysics, biochemistry, biology, and disease pathology, at the third biennial symposium, “RNA: From Bio...

Calling all #RNA #Scientists :
🧪 🧬 Register now to attend the free RNAsymposium at Wertheim UF Scripps on April 14-15. Participate in deep discussions about RNA biology and drug discovery. See you in Jupiter, #FL ! 🧪🧬
#science #academicsky Register: wertheim.scripps.ufl.edu/departments/...

A Novel Ribonuclease Targeting Small Molecule RNA-Degrader (MYC-RiboTAC) Overcomes MYC Dependency in Multiple Myeloma c-MYC (MYC) is an important oncogene in multiple myeloma (MM), driving MM cell proliferation, metabolism, and survival. However, MYC has been challeng…

Great coverage, thanks Jonathan. Did you happen to see Matt Disney etal's poster on a MYC-riboTAC degrader in multiple myeloma? Great teamwork. www.sciencedirect.com/science/arti...

On #GivingTuesday Your support matters! You can donate one of two ways 💙:

1️⃣ Give online
2️⃣ Give by phone with a credit card: 877-351-2377.
📎 Help us continue to inspire tomorrow's innovators—you can make a donation by visiting this link: wertheim.scripps.ufl.edu/ignite/

Our researchers tackle diseases affecting millions.
Support for innovation has:
🧬 Helped us expand research on Alzheimer’s, autoimmune disease, inflammatory illnesses, and more.
🧬 Accelerated pursuit of RNA medicines against incurable diseases including ALS, muscular dystrophy, and Parkinson’s. 1/2

Structural studies like these require a cryo electron microscope that can visualize things so small it's like seeing a nickel on the face of the moon from your back yard. These structural studies reveal basic biology and the root causes of disease. They also help scientists create new medicines.

High-resolution snapshots of the talin auto-inhibitory states suggest roles in cell adhesion and signaling - Nature Communications Talin controls cell adhesion and motility, impacting disease. 2.7 Å cryoEM structures reveal mobile membrane and F-actin binding domains, and force-sensing readiness, providing insights into the dynam...

This gobstopper molecule holds cells together, helps the heart beat, binds immune cells, and affects cancer metastasis. A recent structural study from Tina Izard, PhD shows dynamic talin. From Nature Communications.
Read the study here:
www.nature.com/articles/s41...

@ufhealthcancer.bsky.social

Greetings, Science BlueSky! We're Wertheim UF Scripps, based in Jupiter, Florida. Follow us for news about the molecular basis of health and disease, and our efforts to discover new treatments for unmet medical needs. #science #chemistry #neuroscience #biology #biotech