Waggoner Lab

Preprint: Targeting the MALT1–MIF–IL-21/IL-17 axis restores glucocorticoid sensitivity in infection-associated steroid-resistant asthma
www.researchsquare.com/article/rs-8...

Preprint: The extracellular matrix- fibroblastic reticular cell axis acts as a dynamic and possibly tunable regulator of the immunological status of lymph nodes
papers.ssrn.com/sol3/papers....

Acute inflammation in macrophages and mice can be alleviated by optimized lncRNAs and delivery vehicle
www.science.org/doi/10.1126/...

@biorxivpreprint.bsky.social Acute Paternal Immune Activation Shapes Embryonic Development and Protects Offspring from Viral Infection
www.biorxiv.org/content/10.6... @upenn.edu
@cambupenn.bsky.social @colinconine.bsky.social @kelliejurado.bsky.social

@biorxivpreprint.bsky.social IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19
www.biorxiv.org/content/10.1... @ki.se

Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum @insight.jci.org
insight.jci.org/articles/vie...

Tissue resident memory T cells uniquely generated after early life metapneumovirus infection can contribute to Th2-driven asthma pathology @insight.jci.org
insight.jci.org/articles/vie...

Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis @natneuro.nature.com
www.nature.com/articles/s41... @ki.se @patrikernfors.bsky.social

STING haplotype alone does not fully account for disease expression in COPA syndrome @jem.org
rupress.org/jem/article-... @institutimagine.bsky.social

Out of many, IL-1 Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al...

@cp-immunity.bsky.social spotlight
Defined molecular and anatomical pathway through which inflammatory signals are sensed by the brain and translated into active social withdrawal
www.cell.com/immunity/ful...
on @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Diversify and conquer: Antibody feedback in the germinal center Pre-existing antibodies restrict naive B cell entry into germinal centers, but how antibody feedback shapes ongoing reactions is unclear. In this issue of Immunity, Barbulescu et al. and Yan et al. sh...

Antigen binding by locally produced high-affinity antibodies promotes epitope diversification, thereby broadening the humoral response @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...

Nutrient stress induces FLI1-mediated repression of pro-survival unfolded protein response programs, disrupting proteostasis and limiting NK cell persistence and function within tumors @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...

Dietary restriction, via glucocorticoids, rewires innate and adaptive immunity, and this leads to the conservation of glucose while maintaining protective host defense
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...

Polystyrene microplastics inhibit tissue-resident phagocyte clearance of dead cells, resulting in concerning consequences for organ function @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...

Spicy food 🌶️reduces diabetes risk: Dietary capsaicin attenuates type 2 diabetes via gut microbiota and bile acid metabolic pathways
www.cell.com/iscience/ful... @cp-iscience.bsky.social

Review @cp-trendsimmuno.bsky.social @unifr.bsky.social
Integration of biochemical and physical cues by patrolling CD8+ T cells
www.cell.com/trends/immun...

Spotlight @cp-trendsimmuno.bsky.social
Two models, one question: how does respiratory syncytial virus cause asthma?
www.cell.com/trends/immun...

Review @cp-trendsbiochem.bsky.social
Regulation of inflammatory gene transcription by ubiquitination and deubiquitination
www.cell.com/trends/bioch...

Commonly used chemotherapeutic agents, 5-FU and cisplatin, can induce mitochondrial DNA mutations in T cells @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts Tiash et al. show that adipocyte extracellular vesicles (adipoEVs) increase in circulation with obesity in mice and humans. Slowed clearance of EVs by tissue-resident macrophages and increased adipoEV...

Adipocyte extracellular vesicles increase in circulation with obesity in mice and humans due to increased production and slowed clearance by tissue-resident macrophages @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol... @washumedicine.bsky.social

MARK2 is a physiologically significant regulator of the circadian clock by regulating phosphorylation of PER2 and other proteins @cp-cellchembiol.bsky.social
www.cell.com/cell-chemica...

Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @ophirklein.bsky.social @jeremierispal.bsky.social @ucsfhealth.bsky.social @cedarssinaihsu.bsky.social

LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Identification and characterization of bone marrow plasma cells producing IFN-γ-neutralizing autoantibodies in adult-onset immunodeficiency @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Turn CAR T against TAMs The diversity of tumor-associated macrophages presents a major challenge to the clinical translation of myeloid cell-targeting strategies. In this issue of Cancer Cell, Yagel et al. and Mateus-Tique e...

IL-12 armored CAR T cells effectively target tumor-promoting macrophage populations and reset the microenvironment toward an anti-cancer mode @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...

CD4+ T cell-driven cytotoxicity, memory-biased T cell states, reduced exhaustion, and microenvironment effects linked to long-term responses to BMCA-CAR-T in multiple myeloma patients @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/... @mskcancercenter.bsky.social

Immune-microbiome coordination defines interferon setpoints in healthy humans @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @spitzerlab.bsky.social @ucsfhealth.bsky.social @joelbabdor.bsky.social
@pennmedicine.bsky.social

Ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself @cellcellpress.bsky.social
www.cell.com/cell/fulltex...