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Joseph Schacherer

@schacherer

Genetics, genomics and yeast lover Professor of Genetics, Strasbourg University

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14.11.2023
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Latest posts by Joseph Schacherer @schacherer

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#Yeast #Genetics Meeting 2026 is in June - Abstract deadline is TODAY! Submit your abstract, attend the meeting this summer in Pacific Grove, CA at #Asilomar Conference Grounds, a 107-acre protected coastal state park located on the Monterey Peninsula. #Yeast26 #YGM2026 genetics-gsa.org/yeast-2026/

05.03.2026 20:03 πŸ‘ 14 πŸ” 7 πŸ’¬ 2 πŸ“Œ 1
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And @groupe-sncf.com to this one 🀣

05.03.2026 18:28 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration We are excited to announce the early-stage release of our S. cerevisiae Β structural interactome mapping project. Using AlphaFold3 (AF3), w...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...

04.03.2026 10:36 πŸ‘ 97 πŸ” 52 πŸ’¬ 6 πŸ“Œ 0
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Homepage - Yeast Genetics Meeting 2026 Visit our website to learn more.

πŸ“’ Reminder: March 5 is the abstract submission deadline for the Yeast Genetics Meeting. Don’t miss the chance to share your workβ€”submit an abstract and encourage colleagues to attend!
genetics-gsa.org/yeast-2026/

04.03.2026 08:57 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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The 2026 GSA Awards: The brightest geneticists combine intellect with excellence in education, research, and mentorship This year’s award recipients bring to the table expertise and leadership that have shaped, and will shape, science for years to come.

Thrilled and honored to be part of the 2026 GSA Award recipient! This honor reflects years of teamwork - huge thanks to everyone who has been part of the #haploteam. Proud to share this with you all! @genetics-gsa.bsky.social
genestogenomes.org/the-2026-gsa...

03.03.2026 20:23 πŸ‘ 6 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
a headshot of David Botstein

a headshot of David Botstein

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD.
www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

02.03.2026 15:39 πŸ‘ 52 πŸ” 29 πŸ’¬ 0 πŸ“Œ 3
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David Botstein | 1942 - 2026 | Online-Tribute.com David was a beloved husband, father, brother, scientist, teacher, mentor, musician, friend, who touched the lives of thousands. David’s wide-ranging scientific career spanned decades with a legacy o…

Sad to learn that David Botstein has passed away. Few people truly shape how you think and do science, and David was definitely one of them. I had a fun and influential time at Princeton with the Botstein, Kruglyak and co gangs. It shaped the way I do science.
www.online-tribute.com/DavidBotstein

02.03.2026 09:35 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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www.biorxiv.org/content/10.6... comparison of commercially available #Saccharomyces #mead yeasts.

Our new preprint w/ @balintnemeth.bsky.social and colleagues compares 13 mead #yeast strains for their phenotype, genome, and presents data on metabolites in experimental mead fermentations.

01.03.2026 10:51 πŸ‘ 15 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0
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Finally…

24.02.2026 17:18 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Beyond Mendel: a call to revisit the genotype–phenotype map through new experimental paradigms Abstract. The long-standing notion that genotypes map to phenotypes through simple one gene–one trait relationships continues to shape both research in the

New Perspective!πŸ”₯It's fascinating how scientists from different fields but interested in the same question [e.g. genotype-phenoytpe relationship] can have such different perspectives. Here we put in our 2 cents wrt genetic effects being context-dependent, and pheno variation being mostly polygenic

18.02.2026 09:55 πŸ‘ 32 πŸ” 20 πŸ’¬ 0 πŸ“Œ 0
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Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related β€˜proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

β€œAncient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

18.02.2026 16:03 πŸ‘ 228 πŸ” 115 πŸ’¬ 8 πŸ“Œ 10
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With @litinice.bsky.social, we built a haploid resource from 33 wild Taiwanese Saccharomyces cerevisiae strains β€” including some of the most genetically divergent Asian lineages β€” to bring natural yeast diversity into a genetically tractable framework. www.biorxiv.org/content/10.6...

16.02.2026 23:34 πŸ‘ 27 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

29.01.2026 15:03 πŸ‘ 42 πŸ” 37 πŸ’¬ 1 πŸ“Œ 2

New lab preprint - Common and rare variant studies for the same trait identify different genes and here Diederik Laman Trip developed a protein network AI enconding to investigate if traits studied by different approaches converge on the same molecular pathways
www.biorxiv.org/content/10.6...

29.01.2026 08:12 πŸ‘ 19 πŸ” 10 πŸ’¬ 2 πŸ“Œ 0
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Discovery of additional ancient genome duplications in yeasts Whole-genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages,1,2 preceding adaptive radiations in vertebrates,3,4,5 t…

Excited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! πŸ§ͺ πŸ„ 🧬
www.sciencedirect.com/science/arti...

28.01.2026 17:49 πŸ‘ 44 πŸ” 17 πŸ’¬ 1 πŸ“Œ 1
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Directors

Expressions of interest: Director at MPI EvolBio (f/m/d) β€” We invite expressions of interest from distinguished scientists in evolutionary biology with a bold, long-term research vision that complements our Institute. More information: www.evolbio.mpg.de/3856225/Dire...

21.01.2026 11:15 πŸ‘ 27 πŸ” 49 πŸ’¬ 0 πŸ“Œ 2
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From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...

✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...

16.10.2025 07:49 πŸ‘ 24 πŸ” 15 πŸ’¬ 0 πŸ“Œ 2
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πŸ“£ #EMBOEvoEco returns in 2026 to uncover the mechanistic foundations of ecological and evolutionary change!

Keynote lectures will spotlight the ecology and evolution of symbiosis.

Submit your abstract for the EMBO Workshop: https://s.embl.org/eae26-01-bl!

13.01.2026 12:26 πŸ‘ 10 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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Abstract submission for #Yeast26 is now open! 🍞🍺

Browse abstract submission topics online and start preparing your abstract today.

Topics include disease models & aging, evolution & population genetics, gene regulation, genomics & systems biology, and more!

Learn more: buff.ly/qotaLne

16.01.2026 14:03 πŸ‘ 4 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Flier for conference with list of name of speakers and discussion leaders, Title for conference "Evolutionary Perspectives of Metabolic,
Cellular and Genomic Diversity in Fungi", 50th Anniversary Conference
Chairs: Bridget Barker & Elaine Bignell. held June 20-21 GRS, June 21-26, GRC. URL https://www.grc.org/cellular-and-molecular-fungal-biology-conference/2026/ and list of speakers names.

Flier for conference with list of name of speakers and discussion leaders, Title for conference "Evolutionary Perspectives of Metabolic, Cellular and Genomic Diversity in Fungi", 50th Anniversary Conference Chairs: Bridget Barker & Elaine Bignell. held June 20-21 GRS, June 21-26, GRC. URL https://www.grc.org/cellular-and-molecular-fungal-biology-conference/2026/ and list of speakers names.

2026 is the 50th anniversary of the Cellular and Molecular Fungal Biology GRC. It will be June 21-26, 2026. Consider attending this is a great meeting if you work in the fungal biology field at genetic / genomic / molecular scale. www.grc.org/cellular-and... πŸ„πŸ§¬πŸ–₯️

13.01.2026 18:33 πŸ‘ 8 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

article from @gillesfischer.bsky.social echoing
www.pnas.org/doi/10.1073/...

10.01.2026 11:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Last work of the lab showing that Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution | PNAS www.pnas.org/doi/10.1073/...

08.01.2026 20:40 πŸ‘ 23 πŸ” 9 πŸ’¬ 2 πŸ“Œ 1
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

First paper of the year for the HaploTeam, showing how domestication repeatedly reshapes sexual–asexual life cycle trade-offs in yeast, and revealing convergent evolution. Huge kudos to the team, brilliantly led by Jing Hou!
www.pnas.org/doi/10.1073/...

09.01.2026 18:10 πŸ‘ 12 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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Yeast Genetics Meeting abstract submission and registration sites are open! Abstract submission and registration for the 2026 Yeast Genetics Meeting are now open! Present at this premier meeting for students, postdoctoral scholars, research staff, principal investigators, and...

#Yeast #Genetics Meeting abstract submission and registration sites are open! Abstracts due March 5!

community.alliancegenome.org/t/yeast-gene...

07.01.2026 16:11 πŸ‘ 8 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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πŸ“’ Open PhD position

Phasing polyploid genomes to decipher their phenotypic & adaptive potential

πŸ“ IGBMC - Strasbourg
⏰ Start: Spring
πŸ” Profile: MSc in bioinformatics, Python/Bash, R, sequencing data experience a plus.
πŸ“© Application: see below

06.01.2026 12:24 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Haploteam christmas dinner πŸŽ„ to celebrate an intense and demanding year, but one punctuated by great successes. What a fantastic team! Thanks to everyone!

17.12.2025 08:35 πŸ‘ 7 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ—žοΈ New preprint from the lab, led by our postdoc Ana GaroΓ±a (not on here) in collab with @andreagiometto.bsky.social: β€œExperimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: β€œhoney, we shrank the yeasts!” πŸŽ₯
www.biorxiv.org/content/10.6...

09.12.2025 17:07 πŸ‘ 71 πŸ” 24 πŸ’¬ 2 πŸ“Œ 3
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Don't wait to book your stay at Fungal 2026!
The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26
genetics-gsa.org/fungal-2026/...

15.12.2025 19:09 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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🧬 Join us at #Yeast26 - Yeast Genetics Meeting!
πŸ“ Asilomar, Pacific Grove, CA
πŸ“… June 13–17, 2026
πŸ“ Abstracts & registration open Jan 5 | Abstracts due March 5
πŸ”— genetics-gsa.org/yeast-2026/
@genetics-gsa.bsky.social

15.12.2025 19:14 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Population-scale chemical response revealed by a barcoded yeast collection Natural genetic variation shapes how microbial populations adapt to environmental and chemical challenges, but scalable approaches to map genotype-phenotype relationships across diverse genetic backgr...

🚨 New preprint! 🚨@haploteam
We built a barcoded collection of 520 natural S. cerevisiae isolates and screened 600+ natural compounds. Six functional response clusters and 100+ GWAS associations reveal how natural variation shapes chemical sensitivity.
πŸ”— Read the preprint: doi.org/10.64898/202...

11.12.2025 08:34 πŸ‘ 14 πŸ” 3 πŸ’¬ 1 πŸ“Œ 2