We’ve mapped the Achilles tendon at single-cell resolution 🧬 — revealing 6 fibroblast types with distinct roles across muscle–tendon zones. A new atlas for understanding injury + repair.
Find our more in our new preprint www.biorxiv.org/content/10.1...
#Tendon #CellAtlas #SpatialTranscriptomics
Sending my deepest condolences. Frank was an amazing human, one of the kindest, cleverest, most supportive out there.
Very excited to see this Translational Perspective by Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer discussing our recent transcriptomics study on the early injury response in human quadriceps tendons in @jphysiol.bsky.social.
Dr Sarah Snelling @sarahsnelling.bsky.social is leading a new study aiming to develop a blood test that could identify markers of osteosarcoma. This could be game-changing for early detection of this disease.
Annemarie’s latest paper is out today!
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
To add to the excitement you can explore our data for your favourite cells and genes here
cellxgene.cziscience.com/collections/...
Fibroblasts & endothelial cells appear to orchestrate the early response to injury in ruptured quads tendons.
Great to see this published in & congratulations to @joletmimpen.bsky.social & the rest of the team.
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Join us online for the @humancellatlas.bsky.social Musculoskeletal Bionetwork seminar on 21st May at 4pm GMT. We're excited to hear about spatial mechano-transcriptomics from Dr Adrien Hallou @halloulab.bsky.social
Open to all interested in MSK atlases in any species!
Register now bit.ly/4jhakA8
Ever torn a tendon? Our study led by @joletmimpen.bsky.social discovered changes in fibroblast and immune cell populations that occur in quadriceps tendon tears.
Read more: doi.org/10.1113/JP28...
@sarahsnelling.bsky.social
@adamcribbs.bsky.social
Calling clinicians, research nurses, lab scientists & bioinformaticians!
Please fill out our short survey on challenges & enablers for #biobanks & #Omics research.
Respondents from #GlobalSouth & #LMICs especially welcome!
@ndorms.bsky.social @humancellatlas.org
bit.ly/41nHHex
Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
Word cloud, circular in shape, with tendon, human, cell, patient, healthy, expression, gene, diseased, patient all in large letters.
It had to be done!
I do love tendons, but other musculoskeletal tissues including synovium should get a bigger mention here - let's see what the next few years bring!
Banner showing the ORS ballot to vote for open seats on the Board of Directors.
A headshot of Megan.
I cannot think of anyone more deserving than Megan Killian (@megankillian.bsky.social) for the Community Council Chair on the ORS Board of Directors ballot 😍
Megan is one of those rare gems who goes above and beyond in making folks feel included and heard. A fantastic human being 👇
t.co/h60xhz38NN
If you're interested in the extracellular matrix of soft tissues and the role ECM plays in osteoarthritis then this systematic review is for you!
boneandjoint.org.uk/Article/10.1...
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation!
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social
www.biorxiv.org/content/10.1...
Thinking of doing a DPhil/PhD? Then take a look at this!
www.ndorms.ox.ac.uk/news/blog/st...
The brilliant @joletmimpen.bsky.social & 2 of our fab students @ndorms.bsky.social discuss PhD & post-PhD life in an interdisciplinary team.
From my perspective it's hugely fun & I'm always learning!
📢 Preprint! How does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
This is figure 1, which shows human adipose tissue retains cellular transcriptional changes after BaS-induced weight loss.
Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg
My first post on bsky☺️
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
