Ana De la Rosa-Herencia

Back to class… eosinophils!!

Brain tumors are “rare” on paper, but when it’s your diagnosis or a loved one’s, it doesn’t feel that way.

On #RareDiseaseDay, help us ensure that rare doesn’t mean overlooked.

Today only, all gifts will be matched up to $20K!

Give by midnight to 2X your impact: BrainTumor.org/RDD

Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement Microglia are key drivers of synapse refinement during development. Ramirez et al. show that astrocytes instruct this process through the secreted synaptogenic protein Hevin/Sparcl1. The proteolytical...

Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement: Neuron www.cell.com/neuron/fullt...

ChEA-KG
Human Transcription Factor Regulatory Network with a Knowledge Graph Interactive User Interface

1554 TFs
>60k upregulated edges
>60k downregulated edges
>170k RummaGEO gene sets

chea-kg.maayanlab.cloud

Maayan Lab bioRxiv 2025
www.biorxiv.org/content/10.1...

More cool pictures from my platform. It is neat to see the behavior of the internet. 🧪 #100daysofnetworks

How a cell regulates its size Metabolism, far from being just a housekeeping function, underlies all changes in cell size and function

For many years, the assumption has been that cell size and function are regulated by genes and associated signaling pathways. But a new study reveals that cell size in fact hinges on metabolism—in particular, the fate of a metabolite called pyruvate. cen.acs.org/biological-c...

#chemsky 🧪

High-resolution map shows dark matter's gravity pulled normal matter into galaxies Scientists have created the highest resolution map of the dark matter that threads through the universe—showing its influence on the formation of stars, galaxies and planets.

Dark Matter Map

"Scientists have created the highest resolution map of the dark matter that threads through the universe—showing its influence on the formation of stars, galaxies and planets."

#News #Science 🧪

Don’t let January blues get in your way💙 #phd

#AlternativeSplicing analysis pipeline

MAJIQ v2 - VOILA v2 modulizer

👉Build gene splicegraph including unannotated, complex elements (e.g. de novo intron retention)
👉Quantify AS events & modules
👉Comparative analysis of GTEx v8 all 53 tissues

#NatComm 2023
www.nature.com/articles/s41...

Diffuse midline glioma tumor cells communicate with microglia through IGSF11-VISTA signaling, a tragetable pathway to promote tumor control
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...

Why cancer can come back years later — and how to stop it Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Understanding why cancers relapse - sometimes years or decades after successful treatment - is a major challenge in the cancer field

This perspective in Nature discusses several of the important recent advances and new studies in the field of tumor dormancy 🧪⚕️

www.nature.com/articles/d41...

Sex-specific astrocyte regulation of spinal motor circuits by Nkx6.1 Astrocytes play essential roles in functioning neuronal circuits and are regulated by regional transcription factors (TFs). Bosquez-Huerta et al. found that the TF Nkx6.1 is specifically expressed in astrocytes of the ventral spinal cord and that its deletion results in sex-specific effects on astrocyte morphology and spinal motor circuits.

Very interesting stuff: sex differences intersect with region-specific transcriptional programs to regulate #astrocyte function www.cell.com/cell-reports...

Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com!

www.nature.com/articles/s41...

Postdoctoral Researcher in "Cancer Neuroscience: the impact of neural activity on 3D genome organization and cellular plasticity in glioblastoma”

Excited to share I’ve received a #SSMF #Consolidator grant!

📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics

🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM

Interested? Apply now 👇
rb.gy/m7xz7b

Yesterday I was invited by #SRUK/CERU to join the British Spanish Society Scholarships at the Spanish Embassy in London ✨🇬🇧🇪🇸 Congrats to all winners, amazing works and people!! Hope to see you again next year…🫢

Sir John Hardy (@uclqsion.bsky.social) is on Esquire’s Better Men List 2025 for pioneering Alzheimer’s research. We’re proud to see him recognised as a role model in science. 🔗 https://www.ucl.ac.uk/brain-sciences/news/ucls-professor-sir-john-hardy-named-esquires-better-men-list-2025

Yup-

#SfN #SocietyForGlia #Astrocytes

ENDING STRONG in Astrocyte land here in San Diego.
Thanks for being an amazing community, and apologies (one last time) for anyone I missed! Please comment below with extra awesome astrocyte sessions.

See you in 2026!

library(tidyplots) study |> tidyplot(x = treatment, y = score, color = treatment) |> add_violin() |> add_data_points_beeswarm(white_border = TRUE) |> rename_x_axis_levels(new_names = c( "A" = "Dog", "B" = "Cat", "C" = "Hamster", "D" = "Dinosaur"))

This is how you can rename axis levels in #tidyplots 🎉

#rstats #dataviz #phd

I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...

🧪🔬🧬🎓So #JamesWatson is dead. Should we honor him for his undeniable essential contributions to modern biology?
No because he was an antisemite, a racist, an eugenecist, a sexist who tried to steal the work of #RosalindFranklin without crediting her. A terrible scientist and human being.

One thing I’m loving about London is discovering all the different Wetherspoons and their décor! Especially this one on Baker Street 🕵️‍♂️

Mini-tyrannosaur lived alongside T. rex, extraordinary fossil confirms Study finds fresh evidence for Nanotyrannus, a dinosaur whose existence has long been debated

Mini-tyrannosaur lived alongside T. rex, extraordinary fossil confirms | Science | AAAS www.science.org/content/arti... 🧪

Grateful for the chance to share my work on #Oligodendroglioma 🧠 at the #SRUK / #CERU meeting this Saturday!
Thanks to the organizers for the flash talk slot — great discussions and inspiring people.
Excited to keep connecting with the UK research community!

New Method Is the Fastest Way To Find the Best Routes | Quanta Magazine A canonical problem in computer science is to find the shortest route to every point in a network. A new approach beats the classic algorithm taught in textbooks.

This is a cool computer science story about a new method to find the shortest path between two points. “This thing might as well have been discovered 50 years ago, but it wasn’t” - Mikkel Thorup 🧪
www.quantamagazine.org/new-method-i...

Nice pic!!! 🥰

While analyzing confocal images of the EVL in zebrafish, I came across something I wasn’t even looking for,
cells in the middle of division❗

A little surprise from today’s imaging session, and honestly, it looked beautiful 😊

Excited to share I’ve recently started as a group leader at the University of Oxford @oncology.ox.ac.uk, @ox.ac.uk

Feeling grateful for the people who’ve helped me get here, and looking forward to growing a lab that asks important questions (and hopefully finds some answers).
#NewPI #CancerResearch

Congrats!!! 🎊

Teamwork makes the dream works! Thank you, PCUK, for your support! @prostatecanceruk.bsky.social
@prostateukprofs.bsky.social