Rikeish R Muralitharan MD, PhD

Gut bacteria presence in the brain is increased after ischemic stroke in mice Systemic infections are a common cause of complications and death after stroke. These infections can occur due to the breakdown of the gut epithelial barrier and the translocation of bacteria from ...

New paper from our team 🧠🦠

After stroke, gut‑derived bacteria can migrate into the brain

Blocking sympathetic tone ↓ gut permeability, ↓ brain bacterial load, and improves motor outcomes—without changing infarct size

Congrats to Dr Alex Peh!

www.tandfonline.com/doi/full/10....

Thank you for the recognition! Grateful for the support from @fzmarques.bsky.social and Malindi, PhD student, lead coordinator for the study. Also to High BP Foundation for the seed funding!

Congratulations Dr Lizzie Kleeman, Dr Carol Gubert, @anthonyjhannan.bsky.social & co-authors 👏👏👏

Thank you for the invitation for @rikeish.bsky.social and I to help with the #microbiome analysis requested by reviewers - a pleasure to work with you as always

@natureportfolio.nature.com

🚀 Big milestone achieved!

GRAINS-BP trial is officially underway as we’ve randomised our first participant.

Huge thanks to @fzmarques.bsky.social, our collaborators, funders, and PhD student Malindi. 🙌

For more information and recruitment, please check out www.marqueslab.com/trials

Rare pathogenic variants in G-protein-coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk Gut microbial metabolites called short-chain fatty acids (SCFAs) confer protection against cardiovascular disease (CVD) and its primary risk factor, hypert

Our latest paper is out in Cardiovascular Research

We used a genetics approach to provide human evidence of gut-to-host crosstalk in how blood pressure is regulated

Authors include Leticia Camargo Tavares, @mattsnelson.bsky.social @rikeish.bsky.social

academic.oup.com/cardiovascre...

Our review on the gut-heart axis published in Circ Res is now out www.ahajournals.org/doi/10.1161/...

We cover gut #microbiome, 'leaky gut', foods & metabolites, +++

Congratulations @mattsnelson.bsky.social @rikeish.bsky.social and our co-authors 👏

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Join our clinical study exploring how fibre supplements may lower BP naturally.
✅ Free health checks
$ Compensation for your time
📍 @AlfredHealth VIC
🔬 Ages 18–75
📲 Apply now: grainsbp@monash.edu
#ClinicalTrials #BP

We addressing the gap in the literature by initiating a #clinical #trial.

Great team effort including Malindi, Vaughan Macefield, Damian Keating, Daniela Carnevale, and @fzmarques.bsky.social.

🧠🦠Can the gut communicate with the brain to regulate BP?

Our latest review explores how microbial metabolites (SCFAs) may regulate BP via the gut–brain axis.
A promising new frontier for hypertension treatment.
📖 Read more: doi.org/10.1042/CS20...

@monashuniversity.bsky.social @nhmrc.bsky.social @fzmarques.bsky.social

🚨 EMCRs in cardiovascular research!

Join our free webinar on the NHMRC Investigator Grant Scheme 🧠

📅 June 3 | 🕥 10:30am–12:00pm ACST
💡 Hear from successful applicants & peer reviewers
🔗 Register now: monash.zoom.us/webinar/regist…
#NHMRC #CardioResearch #EMCR #SACVRN #VicCVRN

Could the connection between the #gutmicrobiome and hypertension pave the way to better management strategies?

New findings in mice provide clues:

How a fat in our diet (omega-6 linoleic acid)—a dietary long-chain polyunsaturated fatty acid) has the potential to promote tumor growth www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org

Congrats @rikeish.bsky.social for your immunofluorescence image making it to the cover 👏👏👏 www.ahajournals.org/journal/res

Also read the ‘Meet the first author’ and accompanying editorial (thanks @annetkiraboc1.bsky.social 👏👏👏)

Paper and 🧵 👇

www.ahajournals.org/doi/full/10....

Super excited to join @ahajournals.bsky.social Hypertension as an #ECR editorial assistant!

Interesting breakdown by @fzmarques.bluesky.social & @rikeish.bsky.social on how the gut #microbiome shapes #bloodpressure of their paper published in #CircRes.

📝 Blog: www.marqueslab.com/post/underst…
📄 Paper: www.ahajournals.org/doi/10.1161/���

#Hypertension @ahajournals.bsky.social

New link revealed between hypertension and the gut Monash University researchers have revealed how the gut – and what we eat – regulates high blood pressure, opening the door to more specialised potential new drugs.

Press release: www.monash.edu/news/article...

Grateful to my mentors @fzmarques.bsky.social Dr Joanne O'Donnell and Charles Mackay who helped guide this work and to all co-authors for the support and funding bodies NHMRC, Heart Foundation Australia, @monashbiol.bsky.social @monashuniversity.bsky.social

Rare pathogenic variants in G-protein coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk Background: Gut microbial metabolites called short-chain fatty acids (SCFA) confer protective effects against cardiovascular disease and high blood pressure. Proposed mechanisms include anti-inflammat...

In short, the answer is yes, there is a gene-environment interaction that increases risk for hypertension. My colleague Dr Leticia Tavares has done more work in this area doi.org/10.1101/2024...

Mechanistic studies were performed in an animal model, so we asked ourselves whether these receptors are relevant to human hypertension

Immune cells and the inflammation are linked to hypertension but direct targeting of immune cells has not been particularly effective. Perhaps we could target these receptors to reduce immune activation instead?

We show that absence of these receptors leads to higher gut permeability (aka leaky gut) associated with higher inflammation in target organ such as the kidney. We also show that the absence of these receptors in immune cells was sufficient to worsen hypertension.

We and others have previously shown that SCFA supplementation can reduce BP but underlying mechanisms were unclear. Here we show that SCFA-receptors are protective in hypertension in the Ang II model.

Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension | Circulation Research BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Sh...

I am super proud and excited to share my latest publication, out now in @ahajournals.bsky.social (www.ahajournals.org/doi/10.1161/...)

People are bad at reporting what they eat. That’s a problem for dietary research Studies that use surveys to link dietary patterns to human health may be irredeemably biased, new paper suggests

www.science.org/content/arti...

The impact of a non-industrialized ("Restore") diet plus a key microbe on improving cardiometaboiic health markers and reducing body-wide inflammation, from a randomized trial
www.cell.com/cell/fulltex... @cellpress.bsky.social open-access

The gut microbiome products and.....
—propensity to eat foods high in sugar
nature.com/articles/s41...
—accelerating cellular senescence
nature.com/articles/s43...

Who’s quitting academia? Data reveal gender gaps in surprising fields Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

🔔🧪 #Women, even in well-represented #scientific fields, are up to 40% more likely than men to leave #research within 20 years (Nature News). Urgent #action is needed to close the #scissor-shaped curve.

#WomenInSTEM #genderequity #diversity #STEM

www.nature.com/articles/d41...

Yes, #SciComm is really underestimated and many researchers are failing still (No you aren't "smarter" when using lots of jargon!) 🧪 make research accessible!