Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
It’s an honor to receive the ACS Chem Biol Young Investigator Award! I’m most grateful for the contributions from all past & present lab members — it is an award for all of you as much as for me. (& also grateful to still be considered young 😅) axial.acs.org/chemical-bio...
@acsbiol.bsky.social 1/2
🚨🏆AWARD ALERT🏅🚨
The @acsbiol.bsky.social Young Investigator Award will honor a graduate student or postdoc in #biochem or #chembio at #ACSFall2025 with a symposium, plaque, and funding🤑.
Nominations are due Tuesday April 1. More details: www.divbiolchem.org/awards/dbc-y...
Flyer for Weill Institute Emerging Scholars Symposium at Cornell University, with QR code at bottom to obtain more information
Some good news: applications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology at Cornell should apply by Apr 14. Please repost! wicmb.cornell.edu/emerging-sch...
AlphaFold 3 prediction of the binding interface between SQSTM1/p62 and SHKBP1
Lin Luan
Xiaofu Cao
Our latest story: a protein-protein interaction between an E3 ubiquitin ligase and an autophagy adaptor affects liquid-liquid phase separation and sequestration of a key mediator of antioxidant signaling — but not via ubiquitination! Bravo to Lin Luan and Xiaofu Cao!
doi.org/10.1101/2025...
The actions of the Trump administration make me think of this quote 😞
en.wikipedia.org/wiki/First_t....
Are you a Japanese student interested in a postdoctoral fellowship in the US? The Chan Zuckerberg Initiative has an exciting new fully-funded Global Science Scholars program to pair students who have received their undergraduate or doctoral degrees in Japan with US bioengineering and biomedical...
We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?”
You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw
Thank you Johannes!! 🥰
Thank you, Jeremy!!!
My personal #lipidtime highlight is antigen-gated control of Gq/DAG signaling!🚦 Using PAGER-Gq, we showed DAG production driven by soluble and surface antigens in HEK cells and neurons. Plus, neuron images reveal local DAG production at antigen-contact membranes! Can it be something useful?🤔
Thank you so much, Sam, for highlighting our work!
Our paper about the development of programmable antigen-gated G-protein-coupled engineered receptors (PAGERs) is published today! www.nature.com/articles/s41...
PAGERs couple detection of a wide range of custom-defined antigen to a variety of output including transgene expression and cell signaling.
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
