Alejandro Adam

Jenna Norton is absolutely right. Thank you for speaking up.

@holdenthorp.bsky.social, as someone that grew under a military dictatorship, I can safely say that keeping your head down is not an effective act of resistance.
As scientists, we do our work by keeping our head up and speaking the truth.

GIFT LINK to this very important news story:
share.inquirer.com/sIiF3w

😲 This is THE most amazing thing I've seen this year. (And that's saying something!)

A ResistDance retelling of ICE murdering Renee Good & Alex Pretti enacted through dance‼️😭

Performed by First Amendment Troop in DC. 🤍

I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..

A few points and new information that bioscientists may find interesting...

A 🧵

pretty wild statement re: Republican Chris Madel drop from race for MN governor:

"Saying he cannot support the national GOP's 'stated retribution on citizens of our state, nor can I count myself a member of a party that would do so."

Make Your Voice Heard! Both the House of Representatives and the Senate have advanced draft spending bills that maintain federal funding for lifesaving...

NAVBO is joining the January 21st Day of Action to urge increased FY26 funding for medical research! 🧪🫀🔬

✅ Join us: speak4.app/lp/6t01dslt/...

#SupportCures #FundMedicalResearch #CuresCantWait

THE NOBEL PEACE PRIZE MENU = • Knut Hamsun (Literature Prize 1920): In 1943, the Norwegian author Knut Hamsun travelled to Germany and met with Propaganda Minister Joseph Goebbels. After returning to Norway, he sent his Nobel medal to Goebbels as a gesture of thanks for the meeting. Goebbels was honoured by the gift. The present whereabouts of the medal are unknown.

Trump joins a not-so-long list of people who have acquired someone else's Nobel medal, including... uh... Joseph Goebbels. www.nobelpeaceprize.org/press/press-...

ROV pilots filmed this giant phantom jelly, or Stygiomedusa gigantea, at 253 meters during an ROV descent to explore the Colorado-Rawson submarine canyon wall. #ArgentinianDeepSeeps

a cartoon of spongebob reading a piece of paper with the words my new year 's resolutions above him ALT: a cartoon of spongebob reading a piece of paper with the words my new year 's resolutions above him

@governor.ny.gov we’re set on one goal in 2026: getting EBRI up & running so New Yorkers get the benefits ASAP after such a hard year for many.

EBRI is a transformative investment bringing new medicines & money that can solve other priorities in education, healthcare, transport for the long term.

NY medical schools press Gov. Hochul to put up billions for scientific research The request comes amid continuing uncertainty over federal funding, with research and thousands of jobs on the line.

As a doctor and scientist working to advance health, science, and economic growth in NY, I’m urging @governor.ny.gov to invest in the Empire Biomedical Research Institute to keep the state competitive, sustain jobs, and grow our life science economy.
@gothamist.com reports: tinyurl.com/5fab5k7u

Join us in Fort Myers to #connect, #share, and #learn from the leading #DiseaseResearchers at #Pathobiology2026! Submit your abstract and register to save by by January 20 pathobiology2026.asip.org

#DiseaseMechanisms #ASIP2026 #CareerDevelopment #PathobiologyResearch

Cartmans Mum gets a shot YouTube video by Cat Uploader

I stumbled across the 300th Episode of South Park, SHOTS!!!

One on the most funny/not funny things I have seen in a while.

It is about vaccinations and concerns about vaccine hesitancy and that vaccinations cause people to become "artistic".

www.youtube.com/watch?v=QZ40...

Last week, ICE arrested and separated a father and son after a routine check-in. Six-year-old Yuanxin had just enrolled in the first grade at an elementary school in Astoria. Now he's in custody, alone. ICE won't say where. This cruelty serves no one. It must end.

White background, red ribbon. Text says “World AIDS Day”.

My wife has been HIV+ for 34 years. She’s alive today b/c work of activists who destigmatized the virus, pushed medical science to adapt & find ways to treat it, & advocated for gov health programs that helped fund her care. The current U.S. regime may want to go back in time, but we won’t let them.

Great culture can save lives. Literally.

Amazing letter in today’s @thetimes.com about Tom Stoppard

An obviously AI-generated figure with AI slop and fake text all over it, recently published in Scientific Reports.

Since AI slop is again all over Scientific Reports, a thread on the economics of grey-zone publishing.

Why does slop keep getting published? What does it mean for science? How can we stop this?

Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy

Socialism is what they called public power.

Socialism is what they called social security.

Socialism is what they called the growth of free and independent labor organizations.

Socialism is their name for almost anything that helps all the people.

—Harry Truman, 1952

This team are searching for new "Asgard archaea" to sequence.

Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.

Once considered a type of oddball bacteria🦠...

So, I have read articles written by people who claim that the entire concept of modern medicine is bad, because "artificially" saving people's lives has put a stop to human evolution by letting genetically inferior people breed. Great that those folks are in charge of the CDC now.

Congratulations Margarida Barroso @barroso8.bsky.social for receiving the Carpenter Ranch Award from @histochemicalsoc.bsky.social ! So well deserved!

I wanted to share probably the most important sermon I’ve given and it’s while I’m being arrested. It’s torture pure and simple what happens at #Broadview. I’m ok, though I was thrown to the ground and choked with my pectoral cross. A review of the video shows I was peaceful - did I deserve this?

Without monkeys, neuroscience has no future Research in primate brains has been essential for the development of BCIs, ANNs. New funding and policy changes put future such advances at risk.

Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.

#neuroskyence

bit.ly/47MXYLH

Chuck Schumer Helps Pull Democrats Back From Brink Of Courage

Chuck Schumer Helps Pull Democrats Back From Brink Of Courage

Dems. Snatching defeat from the jaws of victory

Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.

This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.

www.jci.org/articles/vie...

The mechanical response of vinculin Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

Vinculin is a simple adapter protein right? Wrong!

That’s been the prevailing view for the 46 years since it was discovered.

Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.

www.science.org/doi/10.1126/...

10/10 EC-specific deletion of STING or a global deletion of STAT1 not only block the interferon-like response, but decrease the severity of the response to LPS

9/10 The transcriptional response involves IRF1, through a mechanism we do not yet fully understand

8/10 In parallel, IL-6 leads to mitochondrial dysfunction and mtDNA release that leads to cGAS/STING signaling