Happy to share this latest article from the Fan Yang group (Stanford), where microribbons were used as a bioink for 3D bioprinting.
Very grateful to have contributed by analyzing the printed materials :)
doi.org/10.1016/j.bi...
#3dprinting #biomaterials #chemsky π§ͺπ©βπ¬
Biorthogonal PEGylation of Hierarchical Porous MetalβOrganic Frameworks as Robust, Functional Nanocarriers for Hemoglobin-Based Oxygen Delivery http://dx.doi.org/10.1021/jacs.5c10582
Play a little game and choose the right icon for each role in science.
Play our CRediT Roles icon game/survey, and help make scientific authorship clearer and more accessible!
creditsurvey.sciux.org
#OpenScience #ScienceUX
Presenting my project on Modulating oxygen tension in bone tissue engineering via hemoglobin-loaded microribbon hydrogels.
Sunset view at BMES 2025
I had a great time attending and presenting my work at #BMES2025 in San Diego. It was such a nice opportunity to talk about my and others' projects on bone tissue engineering. Thank you everyone for the great talks! π§ͺπ©βπ¬
Red vine leaves turned red on a wall/building in autumn
π Beautiful autumn atmosphere at #DTU this morning
#Autumn
#Photography
#Nature
#Morninglight
Poster T37. Modulating oxygen tension in bone tissue engineering via hemoglobin-loaded microribbon hydrogels.
Excited to be attending #BMES2025!
I will be presenting my work on fabricating oxygen releasing scaffolds for bone tissue engineering in Friday's poster session (T37). Interested in targeting hypoxia, hemoglobin-based oxygen carriers, or bone TE? Please come say hi π
π§ͺπ©βπ¬
Cartoon from the Nobel Assembly showing the three prize winners, their names, and βfor their discoveries concerning peripheral immune tolerance.β
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi βfor their discoveries concerning peripheral immune tolerance.β
Whatβs your #1 survival tip for scientific conference season? π
Mine: update LinkedIn, sponsor others, and do something fun off-site
Read more about why these 3 strategies work on the Thriving Ibis blog: www.thrivingibis.com/post/3-must-...
#AcademicSky #WomenInSTEM #WomenInTech #WomenInScience
Excited to be a topic editor for:
Synthetic Biology in Pharmacology: Engineering Circuits and Cells for Therapeutics
We are seeking articles regarding:
- Artificial Cells for Drug Delivery
- Metabolic Engineering for Drug Production
- Synthetic Gene Circuits
tinyurl.com/38j4d6u4
π§ͺπ©βπ¬#Chemsky
Thanks nu.nl for featuring our recent research results on GRACE #bioprinting @natureportfolio.nature.com . Check out the "good news" section (a fitting home and anme!) of Nu . nl of today:
π³π± www.nu.nl/goed-nieuws/...
@utrechtuniversity.bsky.social
#3dprinting
Scientists at the Wyss have created cellular "backpacks," disk-shaped nanoparticles that can stick to immune cells without being engulfed, and release a steady stream of cytokines into their "host" cells to keep them activated.
Some say that #MOF were discovered in 1900s, but this figure from 1760s clearly show a crystal structure of a MOF with inclusion in pores. Look - metal centers, linkers, guest molecules, all in!
#MOF #chemsky #BraggYourPattern reporting from Portugal
New research shows that simply changing how a reaction vessel is positioned on a magnetic stirrer can significantly change a reaction's speed and product quality, influencing the reproducibility of results. #ChemSky #ScienceSky #EduSky
Instant assembly of collagen for tissue engineering and bioprinting
->Nature | More info from EcoSearch
Great to work on this review with Miguel Castilho, @ruidomingues.bsky.social and colleagues - we outline methods to design responsive #biomaterials that enable fabrication of more complex multicellular systems:
www.cell.com/trends/biote...
#TissueEngineering
Not sure where to publish your research? Here are 7 bookmark-worthy tools that help you decide on the right target journal or repository for your research!
A thread. π§΅
#ScienceSky
#PhDSky
#Postdoc
Check out this recent article from @bioe-stanford.bsky.social⬠on donor variability and 3D culture models influence human mesenchymal stem cell differentiation!
Read more here: doi.org/10.1089/ten....
Three new cases reported on using artificial oxygen carriers, by Dr Zhen Mei (UCLA, US).
HBOC-201 was successfully used on sickle cell disease patients as bridge therapy and/or as substitute for allogeneic blood transfusion.
doi.org/10.1097/MJT....
π§ͺ #MedSky #HBOCs
Extremely excited to share our latest research in Nature Communications @naturecomms.bsky.social! We show that inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles. Congratulations to all authors!! rdcu.be/d68EH @umbaltimore.bsky.social
The mononuclear phagocyte system obscures theΒ accurate diagnosis ofΒ infected joint replacements, by Manasherob et al. Published in the Journal of Tranlational medicine, 2024. https://doi.org/10.1186/s12967-024-05866-5. Below: Schematic understanding of dormant infection (green) as an MPS-mediated IL17 response to biofilm inhibiting PMN recruitment and function when compared to patients with (red) or without (blue) and active infection.
Attended an interesting talk by Prof. Derek Amanatullah (Stanford Med), discussing dormant infections in joint replacements. Concl.: MPS-mediated response as biomarker enables better screening and patient prognosis.
doi.org/10.1186/s129...
#AcademicSky #MedSky π§ͺ
@stanfordmedicine.bsky.social
Fully agree with this piece π§ͺ
In the past, I've contacted a Prof that miscited my paper (we did do the research, just in another ref). No response..
I think the reason is the long process of corrections post publ. So, better to ignore. Wrong citations should be treated easier, it will help everyone
It shows that each approach has its adv/disadvantages, whether using stem cells or particle systems.
While I am more interested in the latter, it is good to follow all the progresses made in each approach. Knowing a clinical trial was done in 2022 shows great promise for artificial blood!
Interesting & short article about artificial blood in Aljazeera, focusing on lab-grown blood (the alternative to HBOCs /PFCs).
Also summarizes their main disadvantage: "producing lab-grown blood is currently much more expensive than using donated blood".
1/2
π§ͺ #chemsky
Another TissueTalk is online, this time with with Prof. Warren Grayson (John Hopkins U, US)π§ͺ
www.youtube.com/watch?v=yNuK...
Gave a clear introduction to the use of scRNA-seq in deciphering cellsβ expressions during bone regeneration. Looking forward to reading the article on this.
#biomaterials
Paper: Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases, by Mohanto et al. Published in Journal of Nanobiotechnology, 2025. https://doi.org/10.1186/s12951-024-03060-9 TOC shows the four discussed products: hemoglobin-, perfluorocarbon-, stem cell-, and micro/nanobubble-based oxygen carriers. For each product, various disease models are targeted. These include i.a. hemorrhagic shock, oxygen preservation, tumor hypoxia, respiratory failure, stroke, chronic hypoxia, and sickle cell crisis. Fig 9 shows the required goals for the perfect O2 carrier. Include i.a. efficient O2 release, extended half-life, innate to inflammatory system, and no acute or long-term toxicities.
New review paper on artificial O2 carriers by Mohanto et al (Shosun U, KR)π§ͺ
-Products: Hb-, PFC-, stem cell-, bubble-based O2 carriers
-Targets incl: anemia, tumor hypoxia, hemor. shock, tissue regeneration, organ preservation
-Finishes with key considerations for future
doi.org/10.1186/s129...
Paint Our Research page on the Fan Yang Lab website. Showing the first three painings called: Tree of Life, Conversations, and the Crabs Cycle
Another way to showcase the group's researchπ©βπ¨π§ͺ
www.fanyanggroup.com/paintourrese...
Visit the site to see all 14 paintings (and maybe more to come!)
#AcademicSky
![Paper: Nanoparticle O2 Carrier Composed of a Polymerized Stroma-Free Hemoglobin Core and Serum Albumin Shell as a Red Blood Cell Alternative in Hemorrhagic Shock Therapy, by Kohyama et al. 2025, ACS Applied bio materials. https://doi.org/10.1021/acsabm.4c01901
TOC showing SFHbNPs product in solution, schematic of the NP system and the in vivo model. Fig 3. (A) Visible absorption spectral changes of SFHbNP at 25 Β°C (in PBS, pH 7.4). (B) O2 dissociation curves of SFHbNP, Hb, and RBC at37 Β°C (in PBS, pH 7.4). Fig 4. Changes in (A) survival rate and (B) MAP in anesthetized rats during the hemorrhagic shock and following resuscitation with SFHbNP solution ([Hb] = 5 g dLβ1, in PBS with 3 g dLβ1 HSA, pH 7.4) and controls (SAB, RL).](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:tqor7h2oefvnoze4k2dn6m5e/bafkreifwwbg5bpwewmg4aoa6c3w6twd3aljolugvhyenjrwp6fixicfe6a)
Paper: Nanoparticle O2 Carrier Composed of a Polymerized Stroma-Free Hemoglobin Core and Serum Albumin Shell as a Red Blood Cell Alternative in Hemorrhagic Shock Therapy, by Kohyama et al. 2025, ACS Applied bio materials. https://doi.org/10.1021/acsabm.4c01901 TOC showing SFHbNPs product in solution, schematic of the NP system and the in vivo model. Fig 3. (A) Visible absorption spectral changes of SFHbNP at 25 Β°C (in PBS, pH 7.4). (B) O2 dissociation curves of SFHbNP, Hb, and RBC at37 Β°C (in PBS, pH 7.4). Fig 4. Changes in (A) survival rate and (B) MAP in anesthetized rats during the hemorrhagic shock and following resuscitation with SFHbNP solution ([Hb] = 5 g dLβ1, in PBS with 3 g dLβ1 HSA, pH 7.4) and controls (SAB, RL).
New HBOC paper out by the Komatsu group (Chuo U, JP)π§ͺ
- HSA-coated SFHbNPs (30 nm), to evade RES
- NPs shows good functionality, with p50=8 Torr
- Full resuscitation in hemorrhagic shock model, with similar results as the shed autologous blood (SAB) control
doi.org/10.1021/acsa...
#chemsky
[πππ° ππ₯π¨π ] Only ~10% of drugs have been tested for safety in pregnant women, risking unexpected side effects. In collaboration with esqLABs, Bayer & Placenta Lab we developed an #organonchip platform to study if small molecules can cross the blood-placenta-barrier. Read it here: shorturl.at/5gfpY
