apreston243.bsky.social

Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by Micromonospora sp. RV43 The urgent need for new antibiotics emphasizes the importance of investigating the many biosynthetic gene clusters that remain silent under standard culture conditions and of assigning functions to th...

New paper alert! Using understanding of a compounds function to inform regulation of biosynthesis of potential antimicrobial compounds. @microbiologysociety.org @thomastorring.bsky.social www.microbiologyresearch.org/content/jour...

A set of genetic tools for use in Clostridioides difficile and related species The Clostridia are a phylogenetically diverse group of anaerobic, spore-forming bacteria that include species of medical, veterinary and industrial importance. The last two decades have seen major adv...

New paper alert! A toolbox of genetic tools for use in Clostridia, made available to the community. @microbiologysociety.org @robfagan.bsky.social www.microbiologyresearch.org/content/jour...

Killing of Coccidioides by drugs Coccidioidomycosis has long been regarded as one of the most difficult mycoses to eradicate in patients with progressive infection. There are few published studies of inhibition of Coccidioides in vit...

New paper alert! Insight into the effectiveness at killing Cocciodiodes by a spectrum of drugs. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Microbial Primer: Bacterial DNA supercoiling DNA in most bacterial cells is maintained in an underwound state. The DNA double helix responds to underwinding by adopting a minimum energy conformation through the supercoiling of the duplex, the fo...

New Microbial Primer alert! The fundamental must-knows of bacterial DNA supercoiling from the authoritative Charles Dorman. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Microbe Profile: Candidozyma auris: an emergent and resilient yeast and new antifungal strategies Candidozyma auris is an emerging opportunistic yeast that is important because of its multidrug resistance, persistence in healthcare environments and ability to cause outbreaks. Since its discovery i...

New profile alert! The latest microbial profile in Microbiology, the low down on the recently renamed Candidozyma auris. @microbiologysociety.org @leighannsherry.bsky.social www.microbiologyresearch.org/content/jour...

Divergent and overlapping roles of homospermidine and spermidine in Sinorhizobium meliloti physiology and symbiotic performance Unlike most rhizobia, Sinorhizobium meliloti produces spermidine (Spd) in addition to putrescine (Put) and homospermidine (HSpd) as soluble intracellular polyamines. To investigate their roles, we ana...

New paper alert! Spermidine and homospermidine have common and distinct roles in Sinorhizobium meliloti. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Synergistic interactions of ruthenium-based carbon monoxide-releasing molecules and antibiotics in their effects on Escherichia coli The emergence of antibiotic-resistant pathogenic bacteria poses a major and growing public health risk. Because antibiotics act on specific molecular targets, bacteria may evolve resistance mechanisms...

New paper alert! Carbon monoxide releasing molecules potentiate act in synergy with conventional antibiotics, reducing their MICs, across a range of antibiotic classes. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

D-amino acid substitution and cyclization enhance the stability and antimicrobial activity of arginine-rich peptides Cationic peptides, particularly those rich in arginine and/or lysine residues, are usually promising antimicrobial agents effective at low concentrations in laboratory settings. However, their applica...

New paper alert! Cyclisation and incorporation of D-amino acids for enhancing the stability and antimicrobial properties of cationic peptides. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Molecular surveillance of foodborne bacterial pathogens and resistome in food products from Hong Kong Foodborne infections pose an increasing public health challenge worldwide. The problem has been aggravated by the dissemination of antimicrobial resistance genes among zoonotic pathogens, which result...

New paper alert! Foodborne pathogens and antibiotic resistance genes identified among raw food products in Hong Kong raises the need for surveillance. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Microbial Primer: Ancientbiotics – making modern antimicrobials from historical infection remedies The modern antibiotic era began in the early twentieth century, but humans have long used materials from the natural world to attempt to treat the symptoms of infection. In this primer, we will discus...

New primer alert! Microbial primer discussing 'ancientbiotics': the search for 'new' antimicrobials from ancient remedies. @microbiologysociety.org @friendlymicrobe.bsky.social www.microbiologyresearch.org/content/jour...

Extensive hidden prophage diversity in Enterobacter species reveals host specificity and local distribution Bacteriophages are key drivers of bacterial evolution, particularly through their integration as prophages within host genomes. However, the diversity and host specificity of prophages in relevant pat...

New paper alert! Huge prophage diversity among Enterobacter: ecological and clinical perspectives. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Sigma B regulated motility and chemotaxis in Bacillus cereus This study describes an alternative role of the general stress response (GSR) regulated by Sigma B, via the two-component system RsbKY, which is methylated via RsbM, in motility regulation for the per...

New paper alert! New chemotaxis model in Bacillus cereus involving an additional regulatory role for the Sigma B-regulated Hpr-like protein Bc1009 via the unique two-component system RsbKY. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Microbe Profile: Paracoccus denitrificans - a versatile model Paracoccus denitrificans is a metabolically versatile alphaproteobacterium first isolated in 1910 by Martinus Beijerinck. Similarities between the aerobic respiratory chain and membrane composition of...

New profile alert! New microbial profile giving the low down on Paracoccus denitrificans. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Improving a Tn7-based luciferase reporter system for promoter activity studies Single-copy chromosomal integration systems are essential tools for stable gene expression in bacteria, minimizing variability associated with plasmid-based systems. The Tn7 transposon-based system is...

New paper alert! An improved Tn7 lux reporter construct with basal lux expression eliminated. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Variations in carbapenem resistance associated with the VIM-1 metallo-β-lactamase across the Enterobacterales The VIM-1 metallo-β-lactamase enzyme, encoded within class 1 integrons, is found in Gram-negative clinical isolates worldwide and has been linked to outbreaks of bacterial pathogens in nosocomial sett...

New paper alert. Epistatic interactions between plasmid-borne Vim1 and chromosomal genes is involved in Vim1 mediated antibiotic resistance. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Annual Conference 2026 Industry opportunities

Mycobacteria: Challenges and progress - this session tackles urgent global challenges.
M. bovis remains a dominant cause of bovine and zoonotic TB worldwide. Hear from leaders at Annual Conference 2026. Registration is open: microb.io/AC26Register #Microbio26

The glucose uptake inhibitor SgrS is induced by D-serine yet does not contribute to growth arrest in enterohaemorrhagic Escherichia coli Bacterial pathogens sense and respond to host-derived metabolites to regulate virulence and establish successful infections. d-Serine, an amino acid abundant in some extraintestinal environments but s...

Delighted to share the hard work of undergraduate student Ella Rellis and first publication from my group since relocating to TCD. Here we identify a new stress response regulator induced by D-serine. 🦠🔬🧫 @microbiologysociety.org #publishforthecommunity www.microbiologyresearch.org/content/jour...

Strain-dependent contribution of the AcrAB-TolC efflux pump to Klebsiella pneumoniae physiology Klebsiella pneumoniae is a prominent opportunistic pathogen increasingly associated with multidrug resistance and virulence. One of the main mechanisms of antimicrobial resistance in K. pneumoniae is ...

New paper alert! Acr/Tol efflux has strain-specific roles in physiology in Klebsiella pneumoniae. @microbiologysociety.org @ilyasalav.bsky.social www.microbiologyresearch.org/content/jour...

Animal modelling with the Francisella tularensis subspecies holarctica strain OR96-0246 Tularemia is a zoonotic disease caused by Francisella tularensis. Most human cases are caused by F. tularensis ssp. tularensis (type A) or F. tularensis ssp. holarctica (type B), with the former consi...

New paper alert! Establishing the infection properties of a type B Francisella tularensis strain. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model The Staphylococcus aureus type VIIb secretion system (T7SSb) is a multiprotein secretion system that secretes toxins with antibacterial activity, but which is also required for full virulence in anima...

New paper alert! Insight into the type 7 secretion system of Staph aureus, including locus type similarities and role in virulence. @microbiologysociety.org @proftracypalmer.bsky.social www.microbiologyresearch.org/content/jour...

Cas9 modulates Campylobacter jejuni virulence traits inside intestinal epithelial cells The CRISPR-associated protein 9 (Cas9) produced by disease-associated strains of Campylobacter jejuni contributes to full virulence, including immune evasion and bacterial survival inside eukaryotic c...

New paper alert! Campylobacter jejuni Cas9 affects an intriguing array of traits, including intracellular survival. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimized phage isolation Phage therapy is a promising treatment for multidrug-resistant bacterial infections. Due to their high host specificity, phages must be matched to the target clinical strains. Efficiently identifying ...

New paper alert! Elimination of restriction endonuclease activity produces the very useful tool of a Pseudomonas aeruginosa strain that enables propagation and purification of a wide range of phage. @microbiologysociety.org @btemperton.bsky.social www.microbiologyresearch.org/content/jour...

Identification and functional analysis of two oligopeptide transporters supporting the growth of Lacticaseibacillus paracasei strain Shirota in milk Oligopeptide transporters are important proteins in several lactic acid bacteria (LAB) that facilitate the transport of oligopeptides, the primary nitrogen source for growth in milk. Although the prot...

New paper alert! Oligopeptide transporters are used for nitrogen acquisition during growth in milk of Lacticaseibacillus paracasei strain Shirota. Also identifies the individual oligopeptide binding proteins involved. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Interpretation guidance for MHRA regulatory considerations for phage therapeutic products On 4 June 2025, the MHRA published ‘Regulatory considerations for therapeutic use of bacteriophages in the UK’. This was in response to recommendations made by the House of Commons Science, Innovation...

New paper alert! Guidance and perspectives on regulatory considerations for approval of phage therapies. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Microbial Primer: Artificial intelligence for microbiologists Artificial intelligence (AI) and machine learning (ML) are reshaping microbiology, enabling rapid antibiotic discovery, resistance prediction and clinical diagnostics. For microbiologists, the goal is...

New primer alert! Fantastic insight into how to apply machine learning and AI in microbiology. A must read. @microbiologysociety.org @delafuentelab.bsky.social www.microbiologyresearch.org/content/jour...

Mutations in the Esx-3 secretion system confer resistance to multiple chemical scaffolds in Mycobacterium tuberculosis We determined the mechanism of resistance to seven chemical series with potent activity against Mycobacterium tuberculosis. Resistant mutants were isolated against the aminothiazoles, phenylhydrazones...

New paper alert! Mutations in Mtb Esx-3 result in resistance to a broad range of anti-Tb compounds. @microbiologysociety.org @proftanya13.bsky.social www.microbiologyresearch.org/content/jour...

Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria Cellular proliferation relies on the successful coordination and completion of genome replication and segregation. To help achieve this, many bacteria utilize regulatory pathways that ensure DNA repli...

New paper alert! DNA replication and repair conflicts lead to cell death in gram positive bacteria, possible new targets for novel antimicrobials.
@microbiologysociety.org @winterhalterlab.bsky.social www.microbiologyresearch.org/content/jour...

Microbe Profile: Streptomyces formicae KY5: an ANT-ibiotic factory Streptomyces formicae KY5 was isolated from a Tetraponera penzigi plant-ant nest. It is primarily known for its production of the formicamycins, antibiotics with potent activity against Gram-positive ...

New profile alert! Microbial profile: Streptomyces formicae KY5, all you need to know about this formicamycin producing machine. @microbiologysociety.org @matthutchings.bsky.social www.microbiologyresearch.org/content/jour...

Seaweed exposure modulates Escherichia coli plasmid conjugation rate Seaweeds are a common and diverse component of coastal ecosystems and are known to be associated with Escherichia coli due to faecal pollution. As a biotic substrate, beach-cast seaweed may affect bac...

New paper alert! Seaweeds affect plasmid conjugation rates. Insight into the effect of biotic factors on HGT. @microbiologysociety.org
@davvi36.bsky.social www.microbiologyresearch.org/content/jour...

A commentary on the 2025 Annual Conference (Liverpool) Session ‘Beyond the lab – Turning your research into reality’ A session at the annual conference of the Microbiology Society 2025 (Liverpool) was held on gaining impact from basic and applied research, ‘Beyond the lab – Turning your research into reality’. This ...

New paper alert! Commentary on the Micro Soc annual conference 'Beyond the lab' symposium. The role of policy and regulation on translational research. @microbiologysociety.org @nicholden.bsky.social @drgvank.bsky.social www.microbiologyresearch.org/content/jour...