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Katherine Horton

@kchorton

Infectious disease epidemiologist | Assistant Professor in #TB modelling @lshtm.bsky.social | Mama to πŸ‘¦πŸ‘¦πŸ‘¦πŸΆ

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08.02.2024
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Latest posts by Katherine Horton @kchorton

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World TB Day Symposium 2026: 2 weeks to go

Join us in London or online on 24 March for the annual UCL/LSHTM symposium

Topics include:
β€’ Beyond the lungs
β€’ Global trends & health systems
β€’ The potential for AI

Details and registration: www.ucl.ac.uk/tb/events/wo...

@tb-lshtm.bsky.social

09.03.2026 08:35 πŸ‘ 1 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

New paper in @plosmedicine.org led by @aportnoy.bsky.social builds on our analysis of the potential epidemiological impacts of reductions in donor funding for #TB to show the economic burden on affected individuals and their households.

08.03.2026 12:53 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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The potential impact of reduced international donor funding on the household economic burden of tuberculosis in low- and middle-income countries: A modeling study In a modelling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the household economic burden of Tuberculosis in low- and middle-income ...

In this modeling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the household economic burden of tuberculosis in low- and middle-income countries πŸ§ͺ #MedSky #TB
plos.io/4ryyBFX

24.02.2026 10:37 πŸ‘ 16 πŸ” 15 πŸ’¬ 0 πŸ“Œ 2
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Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis: A modelling study Hira Tanvir and colleagues estimate the potential impact of new tuberculosis vaccines under three scenarios of efficacy and conclude that to achieve the greatest impact, vaccines must prevent asymptom...

Our recent modelling study found that the estimated impact of new TB vaccines depends on the efficacy to prevent infectious asymptomatic TB. Read more in our paper out now in @plosmedicine.org!

journals.plos.org/plosmedicine...

24.02.2026 14:46 πŸ‘ 15 πŸ” 13 πŸ’¬ 1 πŸ“Œ 0

Really excited to share that this work from @aschwalbc.bsky.social estimating the burden of viable Mtb infection is now published in @plosmedicine.org!

13.02.2026 12:19 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Insights on the implementation strategies for a potential new tuberculosis vaccine in South Africa Several tuberculosis (TB) vaccines intended for adults and adolescents are in late-stage clinical trials, but there is limited research into how a new TB vaccine would be introduced. South Africa is a...

Our new paper on strategies for implementing a potential new #TB #vaccine in South Africa is now published in @plosglobalpublichealth.org!

doi.org/10.1371/jour...

04.02.2026 17:06 πŸ‘ 7 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0

PhD position (London, UK)
Real-time modelling of infectious disease outbreaks.
with @sbfnk.bsky.social @anne-cori.bsky.social @seabbs.bsky.social
at @epiforecasts.io @cmmid-lshtm.bsky.social
More details: http://iddjobs.org/jobs/2440

02.01.2026 18:29 πŸ‘ 4 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0
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Another successful "Intro to TB Modelling" course in Copenhagen at #WLHC2025. Over 70 joined to learn about TB modelling!

Followed by the now-traditional TB Modelling and Analysis Consortium social, which was also very well-attended and a lot of fun.

24.11.2025 13:51 πŸ‘ 12 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1

All are welcome to join the Gender Equity in TB Working Group today at 12:30 in Room B4B @theunion.org! We'll share updates on working group activities and host a panel discussion on progress to date and ways forward to ensure an equitable and inclusive #TB response.

20.11.2025 09:06 πŸ‘ 3 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Day 1: the LIGHT Annual Consortium meeting kicks off this morning at the Crown Plaza in Copenhagen.

Consortium partners from Nigeria, Malawi, Kenya, Uganda and the UK meet to discuss the key research findings, research uptake and impact so far.

16.11.2025 09:56 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
University of Glasgow - Postgraduate study - Centres for Doctoral Training - MRC DTP in Precision Medicine - Supervisors and Projects - Projects 2026 - Projects 26 - Peter MacPherson

🚨Fully-funded PhD opportunity!🚨

Interested in researching how to improve risk prediction for people with #tuberculosis #TB and #multimorbidity?

Joint project between @uofgshw.bsky.social 🏴󠁧󠁒󠁳󠁣󠁴󠁿 and @ki.se πŸ‡ΈπŸ‡ͺ, funded by UK MRC.

Details here⬇️

www.gla.ac.uk/postgraduate...

15.11.2025 08:48 πŸ‘ 6 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0

Interested in #TB, equity, and modelling? @reinhouben.bsky.social and I are advertising an MRC LID studentship on heterogeneity in the coverage of community screening for TB @lshtm-tbmod.bsky.social @lshtm.bsky.social.

For more details, visit mrc-lid.lshtm.ac.uk/2026-27-proj...

11.11.2025 08:27 πŸ‘ 3 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1

Many thanks to @theunion.org and @the-independent.com for highlighting our work estimating the impact of reductions in global health funding on #TB morbidity and mortality

@lshtm-tbmod.bsky.social
@tb-lshtm.bsky.social

10.11.2025 22:26 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Combining demographic shifts with age-based resistance prevalence to estimate future antimicrobial resistance burden in Europe and implications for targets: A modelling study Author summary Why was this study done? Infections caused by bacteria that are resistant to antibiotics are a major and growing threat to public health. Older adults and men are at higher risk of...

How will population shifts affect the future burden of #AMR? πŸ‘ΆπŸ‘©β€πŸ¦³ 🧫

We use a new modelling framework to explore future projections of #AMR by age and by sex, as well as interventions for control, building on our earlier findings that AMR isn’t uniform across demographics.

doi.org/10.1371/jour...

05.11.2025 12:06 πŸ‘ 17 πŸ” 9 πŸ’¬ 1 πŸ“Œ 1
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Impact of fluoroquinolone resistance on the cost-effectiveness of empiric treatment for multidrug- or rifampicin-resistant tuberculosis The WHO recommends the bedaquiline, pretomanid, and linezolid (BPaL) regimen with the additional fluoroquinolone antibiotic moxifloxacin (BPaLM) for initial treatment of multidrug- or rifampicin-resis...

When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! πŸ¦ πŸ’Š

doi.org/10.1371/jour...

20.10.2025 18:47 πŸ‘ 12 πŸ” 12 πŸ’¬ 1 πŸ“Œ 0
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Climate change and tuberculosis: an analytical framework Climate change is likely to exacerbate a range of determinants that drive tuberculosis, the world's leading cause of death from a single infectious agent. However, tuberculosis is often neglected in w...

Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease
www.thelancet.com/journals/lan...

31.10.2025 09:12 πŸ‘ 22 πŸ” 18 πŸ’¬ 1 πŸ“Œ 0

It was a real pleasure to deliver this Introduction to TB Modelling workshop for representatives from Kenya’s National TB, Leprosy and Lung Disease Programme last week with great discussions about how modelling can be used in policy and programme decisions.

30.10.2025 11:38 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Our analysis highlights underappreciated patterns in #TB exposure and transmission that are directly relevant to efforts to end TB. More systematic analyses to understand the epidemiology of TB transmission should be used to inform context-specific prevention and care strategies.

12.10.2025 12:51 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Across age groups, TB exposure typically peaked in adolescence. However, transmission contributions by age varied across regions with the highest proportion from adolescents aged 15-24 in AMR and SEAR, adults aged 35-44 in AFR and EUR, and older adults 65+ in EMR and WPR.

[NOT YET PEER REVIEWED]

12.10.2025 12:51 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 1

Both exposure and transmission were higher in males than in females. We found that a majority of TB transmission was attributable to contact with adult men: 67% (95% UI 62-71%) of transmission to men, 52% (95% UI 49-56%) to women, and 63% (95% UI 58-68%) to children.

[NOT YET PEER REVIEWED]

12.10.2025 12:51 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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A global analysis of patterns of tuberculosis exposure and transmission Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...

Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries.

bit.ly/4nbV492

12.10.2025 12:51 πŸ‘ 16 πŸ” 17 πŸ’¬ 1 πŸ“Œ 0
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Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...

In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...

07.10.2025 09:17 πŸ‘ 12 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0
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New approaches for modelling tuberculosis transmission in low incidence settings at University of Bristol on FindAPhD.com PhD Project - New approaches for modelling tuberculosis transmission in low incidence settings at University of Bristol, listed on FindAPhD.com

PhD opportunity: New approaches to modelling TB transmission in low-incidence settings.
Supervised by Ellen Brooks-Pollock (Bristol), me (Bath) & Rajeka Lazarus (Bristol)
Apply: www.findaphd.com/phds/project...
Deadline 20 Oct
#PhD #Tuberculosis #Epidemiology #InfectiousDisease

27.09.2025 07:10 πŸ‘ 5 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0

Our systematic review of rural/urban differences in #TB prevalence shows evidence of rapidly urbanising epidemics in many settings, with differences across countries and regions.

Link to preprint below ⬇️

22.09.2025 07:55 πŸ‘ 8 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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Sad (but not surprised) to read the latest Global Health 50/50 report, amidst turmoil in global health, erosion of democracy, withdrawal from multi-lateralism, aid cuts, attacks on science, DEI, human rights

@kentbuse.bsky.social @jocalynclark.bsky.social

global5050.org/2025-report/

15.09.2025 16:20 πŸ‘ 22 πŸ” 16 πŸ’¬ 1 πŸ“Œ 0

Men are more than twice as likely as women to have prevalent #TB.

We did updated meta-analysis including over 4million people in 99 surveys.

Despite increasing focus on gender equitable TB responses, this gap has widened since we last assessed these data over a decade ago.

16.09.2025 13:14 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

6/ @petermacp.bsky.social and I seem to be the only coauthors on Bluesky, but this work comes from a great team across @hsph.harvard.edu @uofglasgow.bsky.social @tb-lshtm.bsky.social @lshtm-tbmod.bsky.social

16.09.2025 11:50 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

5/ These findings show that, despite calls for gender responsive TB prevention and care, disparities have increased over the past three decades. Effective strategies to reduce men’s risk of TB and to engage men in TB prevention and care remain essential to end TB.

NOT PEER REVIEWED

16.09.2025 11:50 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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4/ The stability of pooled estimates doesn't mean sex ratios have remained consistent. We found evidence that male-to-female ratios likely increased 1.6% (95% CrI -1.0-6.2%) annually over the period 1994–2021, with the greatest increase in the Western Pacific region.

NOT PEER REVIEWED

16.09.2025 11:50 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

3/ We fitted multi-level Bayesian regression models to estimate a pooled male-to-female prevalence ratio of 2.21 (95% CrI 1.94-2.50) for bacteriologically-confirmed TB.

That's the same point estimate as our previous review, but the two studies used different analytical methods.

NOT PEER REVIEWED

16.09.2025 11:50 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0