Peter Rodgers

Microglia: Replacing the immune system of the brain A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.

Surrogates can be used to study microglial biology and to model neuroinflammatory diseases.
elifesciences.org/articles/110...
elifesciences.org/articles/102...

Microglia: Replacing the immune system of the brain A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.

Making surrogates for microglia
Articles in @elife.bsky.social explain how progenitor cells isolated from bone marrow can be converted into microglia-like cells. (1/2)

For International Women’s day: a recent Feature Article in @elife.bsky.social highlights four women whose pioneering contributions to science have been largely overlooked.
Ethel Browne Harvey; Hilde Mangold; Ida Henrietta Hyde; Marthe Gautier
#WomenInScience
elifesciences.org/articles/110...

There’s more to light than meets the eye in Drosophila!!!
Articles in @elife.bsky.social explain how an ancient photoreceptor that senses light outside of the retina can regulate how flies respond to a range of visual cues.
elifesciences.org/reviewed-pre...
elifesciences.org/articles/110...

How can moths navigate for THOUSANDS of kilometres in the dark?
Read more in this research article and related Insight article about moths called fall armyworms in @elife.bsky.social:
elifesciences.org/reviewed-pre...
elifesciences.org/articles/110...

Image credit: David Hobern CC BY 2.0

Thanks @berniefolan.bsky.social and @dacrotty.bsky.social In the first instance authors could decide that publication as a preprint is enough for thier purposes

eLife’s Global South Committee is hosting a free webinar exploring Diamond Open Access, featuring a range of industry perspectives and highlighting successful implementations from around the world.

Register free: elifesciences.org/events/94216...

📣 We are looking for others to replicate our work!

🔗 More information: nanobubbles.hypotheses.org/replication-...

Marthe Gautier had a vital role in discovering that Down syndrome is caused by an extra copy of chromosome 21

Latest Feature Article in @elife.bsky.social e.bsky.social highlights four women whose pioneering contributions to science have been largely overlooked.
Ethel Browne Harvey; Hilde Mangold; Ida Henrietta Hyde; Marthe Gautier
#WomenInScience
elifesciences.org/articles/110...

More articles on lab handbooks from @elife.bsky.social

The SAFE Labs handbook: elifesciences.org/articles/108...
Welcome to the lab:
elifesciences.org/articles/79627
Why every lab needs a handbook: elifesciences.org/articles/88853

6/ These four scientists made foundational contributions to developmental biology and human genetics, yet their work has often been minimised or attributed elsewhere.

The Feature explores why, and what it means for how we tell the history of science.

🔗 buff.ly/eVipb6d

5/ Marthe Gautier played a crucial role in identifying trisomy 21 as the cause of Down syndrome.

Working with minimal institutional support, she built a cytogenetics laboratory from scratch and produced the preparations that revealed an extra chromosome in affected children.

4/ Ida Henrietta Hyde developed one of the first intracellular microelectrodes for stimulating and recording single cells. She opened new ways of studying nervous and circulatory systems, and became the first woman to receive a PhD in physiology from the University of Heidelberg.

3/ As a PhD student, Hilde Pröscholdt Mangold carried out the embryo transplantation experiments that demonstrated the organiser effect in newts. She performed more than 250 transplants, with only a handful surviving to provide the results that shaped the field.

2/ Ethel Browne Harvey’s experiments on hydra helped establish a key idea in developmental biology: that certain tissues can organise the development of an entire body plan.

In 1909, she showed that grafting tissue from the mouth region could induce a second body axis.

UNESCO international day of women and girls in science. celebrating four largely overlooked pioneers in science

1/ Today is UNESCO’s International Day of Women and Girls in Science #IDWGIS

To mark the occasion, Lisa Thomann and Julie Batut highlight four pioneering biologists whose work shaped developmental biology, electrophysiology, and genetics.

🔗 buff.ly/eVipb6d

To finish on a positive note: Marthe Gautier’s name, along with the names of 71 other female scientists, will soon be engraved on the Eiffel Tower, alongside the names of the 72 male scientists that have been present since the tower was opened in 1889.
presse.paris.fr/communiques/...
(fin)

𝗠𝗮𝗿𝘁𝗵𝗲 𝗚𝗮𝘂𝘁𝗶𝗲𝗿 (1925–2022) discovered that individuals with Down syndrome have an extra copy of chromosome 21 (trisomy 21) but her contributions were overlooked for many years.
(5/6)

𝗜𝗱𝗮 𝗛𝗲𝗻𝗿𝗶𝗲𝘁𝘁𝗮 𝗛𝘆𝗱𝗲 (1857–1945) was a physiologist who developed microelectrodes that could stimulate and make measurements on individual cells. She also worked tirelessly to support women in science.
(4/6)

𝗛𝗶𝗹𝗱𝗲 𝗠𝗮𝗻𝗴𝗼𝗹𝗱 (1898–1924) is belatedly receiving recognition for her contribution to the Spemann-Mangold organiser. She died tragically in an accident at the age of 25.
(3/6)

𝗘𝘁𝗵𝗲𝗹 𝗕𝗿𝗼𝘄𝗻𝗲 𝗛𝗮𝗿𝘃𝗲𝘆 (1885–1965) should be better known for her contributions to developmental biology, notably research that was the basis for subsequent work on the Spemann-Mangold organiser.
(2/6)

Equity, Diversity and Inclusion: Four women whose pioneering contributions to science have been largely overlooked Ethel Browne Harvey, Hilde Pröscholdt Mangold, Ida Henrietta Hyde and Marthe Gautier all made important contributions to developmental biology, but their names are largely absent from histories of sci...

Feature Article in @elife.bsky.social about four women whose pioneering contributions to science have been largely overlooked.
elifesciences.org/articles/110...
(1/6)

Advancing gender equality in STEM education: Inspiring girls to pursue Women and girls remain underrepresented in science, technology, engineering and mathematics (STEM), often due to persistent stereotypes and limited access to opportunities. Through education

Today is International Day of Girls and Women in Science. UNESCO show that women represent only 35% of STEM graduates around the world. We must stop losing so much talent that could improve the world for all www.unesco.org/en/articles/...

In particular, careers in research remain precarious, professional development continues to be undervalued, and the concordat lacks visibility in many institutions. (2/2)
#ResearchCulture

Research Culture: Going beyond compliance to build on the Researcher Development Concordat An agreement between universities, research institutes and funders to support the career development of researchers in the UK has led to improvements in research culture since 2019, but there is still...

Feature Article in @elife.bsky.social about efforts to improve #ResearchCulture in the UK. The Researcher Development Concordat has led to improvements, but there is still more to do. (1/2)
elifesciences.org/articles/110...

Feature article in @elife.bsky.social about the safelabs.info
project

HARSH!!!
One day you are the editor-in-chief of @nature.com
Next, according to @science.org, you are an “Unaffiliated scholar, London, UK”

AI leads to surge in the number of letters being sent to scientific journals or, as one editor-in-chief puts it - “the mass production of junk”

@vtraag.bsky.social et al. found the Matthew effect to be robust across 14 funders, and to generalize from those close to the funding threshold to the whole population.

However, early-career setback effect was not robust across funders and did not generalize to the whole population.

Those just below were - perhaps surprisingly - were found to be more likely to go on to have stronger publication records (early-career setback effect).