Chris Chang

Congrats Gen!

An Inverse Electron-Demand Diels–Alder Approach to Selective Activity-Based Sensing of Acetaldehyde in Living Cells Acetaldehyde (AA) is a reactive aldehyde primarily produced in cells as a metabolic intermediate during ethanol oxidation. Excess AA, often resulting from impaired AA detoxification, leads to aberrant...

Excited to share work out in @jacs.acspublications.org led by Yuxuan and @genlichem.bsky.social on activity-based sensing of acetaldehyde using an inverse electron-demand Diels-Alder reaction, enabling selective detection of two-carbon metabolism! pubs.acs.org/doi/10.1021/...

As a consequence, copper is a single metal nutrient that now centrally controls both genome integrity and metabolic respiration in the cell. This allows cells with high needs for Cu, like locus coeruleus neurons in the brain, to boost activity while avoiding Cu toxicity from oxidative stress.

Acquisition of a histidine pair in RAD23B from amphibians to reptiles enables it to bind copper, making its ancient DNA repair function Cu-dependent and evolving a new function as a metalloadaptor that regulates all major Cu metallochaperone pathways, including those boosting respiration

RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity Increasing brain complexity is a major step in the evolution of species. Here, we show that, in the transition from amphibians to reptiles, the DNA re…

Copper regulates the evolution of REM sleep and transition of animals from water to land! It all relies on a new “metalloadaptor” function for RAD23B linking Cu uptake to distribution to multiple Cu targets. Tong and Dan co-led this @cp-molcell.bsky.social story www.sciencedirect.com/science/arti...

An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...

Thanks Mircea!

Thanks Boris!

Thanks Gilles!

Congrats to our grad student Angel on this well-earned award! #chemsky #proudadvisor

Happy to celebrate an early 90th birthday for my dear mentor Harry Gray! #chemsky #graynation @nuchemistry.bsky.social

Cool to see this lipid-redox crosstalk!

Cells with low levels of bioavailable Cu or Fe are susceptible to selective killing by chelation therapy to reduce Cu or Fe-dependent cell growth and proliferation, revealing a disease-relevant metal landscape that can be leveraged for new therapeutics chemistry.princeton.edu/news/chang-l... 2/end

Activity-based sensors identify cuproplasia and ferroplasia as druggable metal vulnerabilities in cancer! With @ginadenicola.bsky.social and Adam Renslo, we profile cancer cell lines to find those sensitive to Cu or Fe chelation www.pnas.org/doi/10.1073/... www.pnas.org/doi/10.1073/... #chemsky 1/n

Thanks Matt!

Yes, Michelle and I moved this fall!

An Activity-Based Sensing Approach to Multiplex Mapping of Labile Copper Pools by Stimulated Raman Scattering Molecular imaging with analyte-responsive probes offers a powerful chemical approach to studying biological processes. Many reagents for bioimaging employ a fluorescence readout, but the relatively br...

First Princeton paper! Activity-based sensing plus narrow Raman signatures enable multiplex copper imaging, revealing crosstalk between high antioxidant response element NRF2 activation and low labile Cu in cancer. Fun project with Wei Min’s lab at Columbia! #chemsky pubs.acs.org/doi/10.1021/...

Thanks! We need to do a poll on whether it is “metalloallostery” or “metallostery” 🤭

Thanks for hosting a fantastic day at NCI, was a lot of fun!

Welcome!

Hah! Where it all began…

Thanks, happy to be here!

Inspired by @krishnanyamuna.bsky.social @carolynbertozzi.bsky.social, I’m here too!