Journal of Molecular and Cellular Cardiology

🆕 in JMCC: Genetically encoded biosensors reveal real-time redox dynamics in cytosol and mitochondria of live cells. The study shows metabolic pathways shape compartmental redox balance and that mitochondrial redox status is highly sensitive to stress ⚡️
www.jmcc-online.com/article/S002...

🆕 in JMCC: Acetylation of ACTC1 at K326 and K328 weakens actin-tropomyosin interactions and reduces thin filament inhibition under low Ca²⁺, promoting contractile activation. New work reveals how actin modification can tune cardiac thin filament regulation 🫀 🦾
www.jmcc-online.com/article/S002...

🚨 🆕 in JMCC: Circadian rhythms are essential for cardiovascular health, yet hypertension & heart disease can disrupt the molecular clock itself. This review explores the bidirectional relationship between circadian biology, blood pressure, and CV disease 🕰️ 🫀
www.jmcc-online.com/article/S002...

Cyclic AMP-dependent regulation of ryanodine receptors in healthy and diseased hearts Cyclic adenosine monophosphate (cAMP) is a critical second messenger in cardiomyocytes, regulating essential cellular functions. Upon G-protein-coupled receptor stimulation, adenylyl cyclase (AC)…

New Review in JMCC! Hulsurkar et al. examine how localized cAMP signaling controls ryanodine receptors in healthy and failing hearts, shedding light on Ca²⁺ handling and arrhythmia risk.

www.jmcc-online.com/article/S002...

Single cell transcriptomic landscape of adult and pediatric non-ischemic cardiomyopathy Non-ischemic cardiomyopathy (NICM) is a devastating diagnosis with a wide array of phenotypes, ranging from mild cardiac hypertrophy to end-stage heart failure. Single-cell/nucleus RNA sequencing…

New Review in JMCC! Tadros et al. explore how single cell/nucleus RNA sequencing is transforming our understanding of adult and pediatric non-ischemic cardiomyopathy. These cutting-edge tools are critical for advancing precision cardiovascular medicine.

www.jmcc-online.com/article/S002...

Interplay between variability in intrinsic cellular properties and heart failure-associated remodeling in a simulated population with human heart failure Heart failure (HF) is the presentation of mechanical pump dysfunction, with HF patients facing increased risk of sudden cardiac death predominantly driven by ventricular arrhythmias. At the cellular…

New in JMCC! Miller et al. use a population-based simulation approach to uncover arrhythmia risk in heart failure. The framework captures both intrinsic cellular variability and disease remodeling in human ventricular myocytes.

www.jmcc-online.com/article/S002...

Sphingosine-1-phosphate activates ICl,swell in ventricular myocytes via mitochondrial reactive oxygen production We previously demonstrated that bacterial sphingomyelinase (SMase), which converts plasmalemmal sphingomyelin to long-chain ceramides, activates the swelling-activated chloride current (ICl,swell) in…

New in JMCC! Sphingomyelinase induces the swelling-activated chloride current via production of S1P and mitochondrial ROS- a pathway relevant to cardiac and metabolic diseases.

www.jmcc-online.com/article/S002...

Impaired retinoic acid signaling mediated Rbm20 downregulation induces aberrant splicing of CaV1.2 calcium channel: implications in myocardial hypertrophy Myocardial hypertrophy, a pathological adaptation to chronic stress, predisposes to heart failure through dysregulated calcium handling. Alternative splicing (AS) of CaV1.2 calcium channel…

New insights into cardiac hypertrophic remodeling now in JMCC! 🎉 Song et al. reveal that impaired RARβ suppresses Rbm20 and disrupts CaV1.2 alternative splicing to drive remodeling. Excitingly, RARβ agonism alleviates hypertrophy!

www.jmcc-online.com/article/S002...

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📅 May 31–June 3, 2026
Promoting the next generation of basic and translational scientists. Reserve your spot today! #ISHRNAS2026
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Human atrial skinned muscle fibers exhibit reduced length-dependent activation but show faster force development kinetics than ventricular muscle In humans, the left atria (LA) and the left ventricle (LV) play distinct physiological roles and express sarcomeric proteins with chamber-specific patterns. Despite these important differences, most…

New in JMCC! Atrial muscle fibers show reduced length-dependent activation but faster force development than ventricular muscle. Differences are driven by passive stiffness and cross-bridge kinetics highlighting chamber-specific mechanics in the human heart. 🫀

www.jmcc-online.com/article/S002...

ZIP14 upregulation leads to ferroptosis and lysosomal dysfunction through intracellular iron overload and induces myocardial ischemia/reperfusion injury in mouse hearts While the ZIP family Zn2+ transporters such as ZIP2 and ZIP7 play critical roles in myocardial ischemia/reperfusion (I/R) injury by regulating Zn2+ homeostasis, little is known about the roles of the…

🚨 New insight into I/R injury: Zhao and colleagues identify ZIP14 as a key driver of damage via iron overload, ferroptosis, and lysosomal dysfunction. Even better? Lowering ZIP14 reduces infarct size.

www.jmcc-online.com/article/S002...

Extracellular-cAMP suppresses pulmonary arterial hypertension-induced ventricular arrhythmias Pulmonary Arterial Hypertension (PAH), a major cause of right ventricular failure, is associated with a high 5-year mortality rate. Arrhythmias account for a significant proportion of morbidity and…

Arrhythmias are common in PAH. New work in JMCC shows that treating PAH murine models with e-CAMP significantly reduces cardiac arrhythmias while also improving pathological cardiac and pulmonary vascular remodeling.

www.jmcc-online.com/article/S002...

Inhibition of Pyk2 prevents Cx43 remodeling and cardiomyocyte injury during hypoxic and adrenergic stress Hypoxia induces pathological remodeling in cardiomyocytes, in part by disrupting gap junction communication through Connexin43 (Cx43) phosphorylation and internalization. Here, we identify…

New work in JMCC shows that Pyk2 is critical for hypoxia and adrenergic stress driven Cx43 internalization and cardiomyocyte damage.

www.jmcc-online.com/article/S002...

🚨🆕in JMCC Special Section: The Diabetic Heart This review highlights the angiotensin type 2 receptor (AT2R) as a therapeutic target in diabetic cardiomyopathy. Preclinical data show AT2R agonists ⬇️ inflammation & fibrosis & improve cardiac function.
www.jmcc-online.com/article/S002...

🚨 🆕in JMCC Special Section: Better Together - Exp+comp models in cardiac remodeling. This study shows lactation prolongs postpartum heart growth in mice, while non-lactation reverses hypertrophy. Modeling reveals complementary mechanical and biological drivers.
www.jmcc-online.com/article/S002...

🆕in JMCC: IGF-1 accelerates cardiac pacemaking by increasing cell surface expression of HCN4 channels in the sinoatrial node. This effect depends on Rab11-mediated endocytic recycling, offering a mechanistic explanation for IGF1-associated tachycardia.
www.jmcc-online.com/article/S002...

🆕in JMCC: In silico modeling reveals how stretch-activated ion channels drive ventricular re-entry. Arrhythmias emerge from interactions between stretch-induced depolarization and repolarization, shaped by stimulus timing, spatial gradients, & tissue properties.
www.jmcc-online.com/article/S002...

PhysioMEA: Signal processing platform for rate and rhythm analysis of multi-electrode array cardiac electrophysiological recordings This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

🆕in JMCC: PhysioMEA is a new open-source platform for advanced MEA analysis of cardiac organoids. It expands beyond 1D metrics to 2D electrophysiological biomarkers and beat rate variability, revealing complex spatiotemporal rhythm dynamics.
www.jmcc-online.com/article/S002...

Small-scale siRNA screen reveals WWC2 as a novel regulator of cardiomyocyte mitosis This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

🆕in JMCC: A small-scale siRNA screen identifies WWC2 as a key brake on cardiomyocyte mitosis. Loss of WWC2 activates YAP signaling, enables cytokinesis, and stimulates cardiomyocyte proliferation and cardiac regeneration after myocardial infarction.
www.jmcc-online.com/article/S002...

🆕in JMCC: Fibroblast-specific USP7 drives post-MI cardiac fibrosis by stabilizing KLF7 and activating pro-fibrotic GATA3 signaling. Genetic deletion of USP7 limits myofibroblast activation, improves cardiac function, and mitigates adverse remodeling.
www.jmcc-online.com/article/S002...

🆕in JMCC: Soluble epoxide hydrolase drives HFpEF by reducing cardioprotective EETs and activating CYP2E1. Genetic or pharmacologic sEH inhibition restores EETs, improves diastolic function, and reverses adverse cardiac remodeling in HFpEF.
www.jmcc-online.com/article/S002...

Homocysteine activates endothelial TP receptor to promote von Willebrand factor secretion and thrombosis This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

🆕in JMCC: Homocysteine drives thrombosis by activating endothelial thromboxane prostanoid receptors, triggering vWF secretion and platelet adhesion. Targeting TPr signaling reduces vWF levels and protects against hyperhomocysteinemia-related thrombosis.
www.jmcc-online.com/article/S002...

🆕in JMCC: Loss of the RNA binding protein Qki disrupts cardiac homeostasis, driving cardiac cachexia and death via altered Morf4l2 splicing. Targeting the Morf4l2Δex3 isoform rescues heart function, revealing a new therapeutic avenue 🧬 🫀
www.jmcc-online.com/article/S002...

Slit2-robo signaling regulates angiogenesis and repair following myocardial infarction This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

🆕in JMCC: Slit2-Robo signaling drives cardiac repair after MI. Fibroblast-derived Slit2 boosts angiogenesis, increases vascular density, limits cardiomyocyte hypertrophy, and improves function post-MI, highlighting a new therapeutic pathway for heart repair 💪🏼
www.jmcc-online.com/article/S002...

FABP4, marker of worse prognosis in cardiovascular disease, induces neutrophil's proatherogenic phenotype which is modulated by semaglutide This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

🆕in JMCC: FABP4 emerges as a marker of worse CVD prognosis🫀 Elevated FABP4 drives proinflammatory, proatherogenic neutrophil phenotypes, while semaglutide lowers FABP4 & dampens leukocyte migration & platelet activation pathways 💊 #JMCC #Atherogenisis

www.jmcc-online.com/article/S002...

The long non-coding RNA Snhg15 protects the heart after myocardial infarction This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

🚨 The January issue of JMCC is live! ⭐ Featured study: "The long non-coding RNA Snhg15 protects the heart after myocardial infarction". ⬇️Snhg15 is a hallmark of ischemic & dilated HF, while AAV-Snhg15 limits cardiomyocyte death & improves function after MI 🧬 🫀💪🏼

www.jmcc-online.com/article/S002...

Attention Early Career Investigators: ISHR-NAS is hosting a Winter Webinar on Dec. 4, featuring selected presentations from Post-Docs and PhD Students. Submit your abstract by Oct 31 to be considered for presentation. Learn more & register at ishrnorthamerican.org/eci/

JMCC and JMCC Plus are now on LinkedIn! Follow our joint JMCC Journals account at www.linkedin.com/company/jmcc...

Work from Patrick Boyle at University of Washington shows population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection

Read more: doi.org/10.1016/j.yj...

Editor's Choice! The role of the troponin T interactions with actin in regulation of cardiac thin filament revealed by the troponin T pathogenic variant Ile79Asn

doi.org/10.1016/j.yj...