Viljami Sairanen 's Avatar

Viljami Sairanen

@viljamisairanen

Medical Physicist | PhD | Entrepreneur Researching brain models (dMRI) at Baby Brain Activity Center of the University of Helsinki, https://www.babacenter.fi/ Department chief physicist in radiology at Hämeenlinna Central Hospital, Finland

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25.09.2023
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Latest posts by Viljami Sairanen @viljamisairanen

Tai sitten arvaavat, kun omat tuotteet on kehitetty, että vain hetkellistä taloudellista voittoa ajattelevat poliitikot päättävät myydä ne (case Esko).

28.02.2026 14:52 👍 4 🔁 0 💬 1 📌 0

Not a desk reject! 🥳

10.02.2026 06:50 👍 3 🔁 0 💬 1 📌 0
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Preprint

From nodes to pathways: an edge-centric model of brain structure-function coupling via constrained Laplacians

www.biorxiv.org/content/10.1...

22.01.2026 05:18 👍 2 🔁 0 💬 0 📌 0
rom nodes to pathways: an edge-centric model of brain structure-function coupling via constrained Laplacians Understanding how functional interactions emerge from the brain structure remains a central challenge in network neuroscience. Structural connectivity (SC), derived from diffusion MRI tractography, provides the anatomical scaffold, whereas functional connectivity (FC), measured with fMRI, EEG, or MEG, reflects dynamic neural interactions that often extend beyond direct anatomical links. Existing spectral graph theoretical models successfully capture indirect interactions but largely remain node-centric, leaving the contributions of individual structural pathways implicit. This work introduces an edge-centric framework for structure-function coupling that reformulates the graph Laplacian as a constrained flow problem grounded in spectral graph theory and realized numerically through Modified Nodal Analysis (MNA). Functional relationships are modeled as nodal constraints (voltage sources), structural connections as conductances, and the resulting nodal potentials induce edge-wise flows (currents) that explicitly quantify how functional signals are distributed in anatomical network. This formulation preserves the theoretical foundations of Laplacian eigenmodes while extending them to compute interpretable, pathway-specific measures of functional signal flow. As a proof-of-concept, the framework is demonstrated in three settings: (i) a single-subject Default Mode Network example illustrating tractography filtering and streamline-wise functional currents, (ii) a ground-truth diffusion phantom showing accurate recovery of both direct and indirect pathways, and (iii) a group-level analysis of 207 Human Connectome Project subjects yielding a sparse, current-based connectome complementary to conventional SC and FC matrices. By bridging spectral graph theory and circuit analysis, this approach provides a mathematically consistent and physically interpretable method for mapping functional interactions onto structural brain networks, with practical applications in tractography filtering, network analysis, and multimodal connectomics. ### Competing Interest Statement The authors have declared no competing interest.

The feeling when you notice had made an typo in the title of a preprint 😅🤦‍♂️ thankfully the kind people at bioarxiv told me that it should get fixed automatically because title is correct in the pdf.

www.biorxiv.org/content/10.1...

17.01.2026 16:32 👍 0 🔁 0 💬 0 📌 0

Paristot loppu ja kello jätättää. Käynyt myös Akulle, niin miksei mullekin piirroshahmoille.

25.12.2025 10:41 👍 2 🔁 0 💬 0 📌 0
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🧠New preprint!

What if cortical geometry alone already encodes much of white-matter organization?

We introduce a subject-specific, reversible cortical folding model that unfolds and refolds the brain from a single T1w MRI; no diffusion, no ML.

www.biorxiv.org/content/10.6...

17.12.2025 01:48 👍 34 🔁 11 💬 2 📌 1

Getting a paper status to "under review" after six desk rejects feels already like a victory 🥳 I'm quite sure that even the infamous reviewer two can't be more offensive than some of the editors so far 😅

03.12.2025 06:49 👍 1 🔁 0 💬 0 📌 0
Mitä sairaalafyysikot tekevät? (ENG subs)
Mitä sairaalafyysikot tekevät? (ENG subs) YouTube video by Sairaalafyysikot

Oletko miettinyt, mikä ihme on #sairaalafyysikko tai, mitä kummaa moinen tekee? Tässäpä sinulle hieno yhteenveto alasta: youtu.be/HlFP2CqTiAs?...

Iloista sairaalafysiikan päivää!

07.11.2025 13:48 👍 2 🔁 1 💬 0 📌 0
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Is this a tractogram of the default mode network or a Romulan warship from Star Trek?

18.09.2025 07:20 👍 3 🔁 0 💬 0 📌 0

📢 Excited to share our new paper from Synnöve Carlson’s team! We show how prematurity impacts higher-order brain network dynamics in school-aged children and adolescents:

doi.org/10.1016/j.ne...

#Neuroscience #Brain #Prematurity #BrainHealth #Neurodevelopment

15.09.2025 08:19 👍 2 🔁 1 💬 0 📌 0

Some publisher like Elsewier take this even further: they say that if you review 3 or more papers in a year, you will get this reward. I *bet* that most reviewers will get at th3 most 2 papers to review per year.

28.07.2025 14:42 👍 0 🔁 0 💬 0 📌 0

Yes. Since there is no guarantee on getting the reduction and even less guarantee that reviewer could get a paper published in the same journal (or even publisher), this is not a reward but gambling (masked as a reward).

28.07.2025 13:45 👍 1 🔁 0 💬 1 📌 0

Gambling in science vol 56: this time I refused to review a paper in MDPI journal as they practice gambling (reviewer has a random chance to obtain reduction on their APC fee).

What do you think? Is this gambling or are you just wrong?

28.07.2025 13:16 👍 1 🔁 0 💬 1 📌 0
Preview
Konferenssisanastoa - Nuoren tutkijan elämää Miten konferenssiesitelmä eroaa posteriesitelmästä? Tai mitä tarkoittaa konferenssin työpaja? Oma mielikuvani on, että työpajassa korjataan ja rakennetaan tai upotetaan kädet saveen. Konferenssin työp...

Onko edessä ensimmäinen konferenssi? Etkö oikein tiedä, mitä siellä tapahtuu tai mitä esimerkiksi työpaja tarkoittaa? Ei hätää. Blogissani selitän konferenssiin liittyvää sanastoa.

26.06.2025 09:09 👍 4 🔁 1 💬 0 📌 0

5) I might sound pessimistic but then again the publishers make a shitload of money by providing PDFs and are well known of abusing whatever they can for profit.

I'm just waiting for the microtransactions! Review one paper and you can use *bold font* in your next paper in our prestigious journal!

31.05.2025 18:01 👍 0 🔁 0 💬 0 📌 0

4) The journal can simply reject the paper or delay the review process until the 40% discount is no longer valid (12 to 18 months).

Sure, a few will manage to get this done so the word gets out that the 'deal is true'. The rest just got scammed.

31.05.2025 18:01 👍 0 🔁 0 💬 1 📌 0

3) Skip a good night's sleep and the 4th review gets done! Yay, did you win the game?

No! The *game* has just begun. Now you need to make a paper suited to this journal.

Guess what, it is the journal's decision wether they publish or not your work. Why would they publish with reduced fee? ...

31.05.2025 18:01 👍 0 🔁 0 💬 1 📌 0

2) They don't state if 2 reviews are enough. So you are tempted to do 3rd and 4th to secure the entry ticket for the actual game*. Enter December and all the normal hurdles of end of the year. Then an editor asks you for the fourth review. You really don't have time, but you are already hooked...

31.05.2025 18:01 👍 0 🔁 0 💬 1 📌 0

1) The journal selects reviewers. There is no reason for them to offer fourth reviews equally. Some *will* get it, likewise some might win in a lottery. Majority, however, never will. This is the same old shit with a new color to exploit scientists - but even worse! ...

31.05.2025 18:01 👍 0 🔁 0 💬 1 📌 0

1/5 Loot boxes of academic publishing?

A journal asked me to review a paper. The journal "recognizes reviewers’ contributions via APC waivers". If you review 2-4 papers per year, you will get 40% off the (insanely high) pay-to-win (publish) fee.

Basically, this is the same as playing at casino...

31.05.2025 18:01 👍 2 🔁 0 💬 1 📌 0

Welcome to the dark side! I like how that gets represented even in the gui coloring on the screens (assuming left is Matlab and right is Python)

28.05.2025 07:54 👍 1 🔁 0 💬 2 📌 0

One point on the opening lecture was that the number of members hasn't increased since 2017 but costs are rising and something has to change. And at the same time stuff like this doesn't get support? Seems weird.. Highlights was a true highlight. Sad it is gone.

14.05.2025 05:01 👍 0 🔁 1 💬 1 📌 0

I've missed this discussion! How anyone could justify double space, I wonder?

11.04.2025 03:32 👍 1 🔁 0 💬 2 📌 0

Does anyone with a Siemens Trio have the gradient distortion correction .coef file they'd be willing to send us?
Thanks!

10.04.2025 09:45 👍 0 🔁 5 💬 1 📌 0
Preview
Tutkimus: Potilaan liike sotkee magneettikuvia – uudet menetelmät mahdollistavat sotkun siivoamisen eikä potilasta tarvitse välttämättä kuvata uudestaan

Hyvinvointialueilla tehdään myös tiedettä. Tai ainakin minä teen. Tällä kertaa osana kansainvälistä poppoota ja kohteena 16000 ihmisen magneettikuvat 🧠

omahame.fi/fi/w/tutkimu...

28.02.2025 14:52 👍 3 🔁 1 💬 0 📌 0
Preview
Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross‐Sectional Datasets Across the Lifespan We characterized motion during diffusion MRI scans across 16,995 image sessions and find that (1) modern preprocessing pipelines effectively mitigate motion to the point where biases are not detectab....

It's hard to overstate what a big deal this paper is: onlinelibrary.wiley.com/doi/10.1002/.... Head motion in dMRI is NOT like head motion in BOLD.

13.02.2025 17:42 👍 29 🔁 16 💬 1 📌 1

Miten ennen tutkimuksen aloittamista voisi edes olla varma, että tulokset ei jossain kohtaa saattaisi olla ristiriidassa turvallisuuspolitiikan (=mielipide) kanssa? Katkaistaanko rahoitus kesken ja kenen päätöksellä? Jäätävää, jos tuommoinen muutos menee läpi 🥶

13.02.2025 10:07 👍 1 🔁 0 💬 0 📌 0
Preview
Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross‐Sectional Datasets Across the Lifespan We characterized motion during diffusion MRI scans across 16,995 image sessions and find that (1) modern preprocessing pipelines effectively mitigate motion to the point where biases are not detectab...

Fresh from the press!

Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross-Sectional Datasets Across the Lifespan

Thanks to Kurt Schilling et al. for including me!

dx.doi.org/10.1002/hbm....

#dMRI

12.02.2025 09:42 👍 1 🔁 0 💬 0 📌 0

We are very excited to announce the open release of a new 170 participant dataset: Linked MEG, TMS, multimodal 3T MRI, 7T MRI, Connectom MRI, cognitive /questionnaire data. Immense effort from a fabulous
CUBRIC team. Paper by Carolyn McNabb et al: doi.org/10.1038/s415...

06.02.2025 11:43 👍 144 🔁 67 💬 2 📌 8
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Silly ChatGPT 🤭

26.01.2025 07:15 👍 2 🔁 0 💬 0 📌 0