Anastasia Kurzyukova

📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬

"How cells copy their epigenome"

Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science

Repair of DNA double-strand breaks leaves heritable impairment to genome function Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Epigenome dynamics in early mammalian embryogenesis - Nature Reviews Genetics Upon fertilization and during early mammalian development, major changes in cellular plasticity occur. This is accompanied by large-scale epigenome remodelling, as has been recently highlighted by the...

Our featured article:
Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla go.nature.com/45UA8Ob

The brain fires up immune cells when sick people are nearby When people viewed virtual avatars with coughs or rashes, their brains triggered an immune response.

Curious www.nature.com/articles/d41...

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Epigenetics Update - Bivalent chromatin instructs lineage specification during hematopoiesis bit.ly/3G4GmRv

Hanno Hock and Konrad Hochedlinger (Harvard) reporting in Cell

#Epigenetics #BivalentDomains #Hematopoiesis

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Gain deeper insights into gene regulation at epigenometech.com

Altering metabolism programs cell identity via NAD+-dependent deacetylation | The EMBO Journal imageimageHow alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study shows that forcing OXPHOS metabolism reprograms mouse embryonic stem cells (ESCs) to a more inner cell mass (ICM)-...

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios.
www.embopress.org/doi/full/10....

I believe these rules can apply to anyone, not just those doing a PhD.

Arrived! The Groth lab moved to the Danish Cancer Institute. Beautiful new labs shared with @nilskrietenstein.bsky.social Thanks to everyone at DCI for a warm welcome. We are excited to be here and get experiments going 🧬

Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells Abstract. Epigenetic mechanisms are crucial for developmental programming and can be disrupted by environmental stressors, increasing susceptibility to dis

Happy to share the lab's latest publication from @eli-elder.bsky.social and team in @narjournal.bsky.social ! What happens when #DNAmethylation maintenance is transiently interrupted in mouse embryonic stem cells? Let's dive in (1/11). doi.org/10.1093/nar/...

Targeting heterochromatin eliminates chronic myelomonocytic leukemia malignant stem cells through reactivation of retroelements and immune pathways - Communications Biology Chromatin and transcriptome studies in myelomonocytic leukemia stem cells revealed repression of retroelements and immune genes. Restoring these pathways by co-inhibiting DNA methylation and H3K9me2 e...

Don't miss this work by Donia Hidaoui at INSERM taking an #epigenetics approach to target heterochromatin in malignant stem cells to further options for CMML. They use a LINE-1 assay to analyze 5-hmC globally.

View the research - bit.ly/41Klqr2
See how the assay works - bit.ly/3QK5dfh

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

Exclusive: NIH to terminate hundreds of active research grants Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.

In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”….

🧪 #AcademicSky

www.nature.com/articles/d41...

Fingerprinting the recovery of Antarctic ozone - Nature Pattern-based detection and attribution methods that make use of trend pattern information as a function of month and height provide evidence that reduction of ozone-depleting substances has resulted ...

The ozone hole is healing, thanks to global reduction of CFCs

New results show with high statistical confidence that ozone recovery is going strong.

www.nature.com/articles/s41...

In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes.

Check out the full #preprint: shorturl.at/TJ9BK

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
 
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).

www.embl.org/about/info/c...

Migraine is more than a headache — a radical rethink offers hope to one billion people Drugs that can prevent or relieve migraine attacks are only effective for some people. Research is starting to untangle the reasons why.

Migraine is more than a headache — a broad phenomenon that originates in the brain & can manifest in many debilitating symptoms, including light sensitivities & aura, brain fog & fatigue.
A radical rethink of the condition offers hope to one billion people 🧪 #MedSky

www.nature.com/articles/d41...

Postdocs and PhD students hit hard by Trump’s crackdown on science As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether.

https://go.nature.com/43ao2zq

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Amazing work, congratulations!😊

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC) The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬

What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬

www.science.org/doi/full/10....

Learned the Business Model You framework in the Scientific Project Planning and Management course for PhD students led by Valeska Russo

A temperature-inducible protein module for control of mammalian cell fate - Nature Methods The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...

Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...

🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.

This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.

www.biorxiv.org/content/10.1...

Epigenetics-2025, from mechanisms to disease | Genetics Society Meeting background This international conference will bring together leading experts to foster dynamic discussions on the latest breakthroughs in epigenetics. It will cover mechanisms of epigenetic re...

Join us in Belfast for our #epigenetics meeting and hear from fantastic speakers. Submit an abstract until 26 Jan and register until 23 Feb!

Don't miss this chance to share your research & network with experts in the field.

genetics.org.uk/events/epige...

OpenAI has created an AI model for longevity science The company is making a foray into scientific discovery with an AI built to help manufacture stem cells.

OpenAI has created an AI model for longevity science.
GPT-4b micro is for protein engineering, re-engineering Yamanaka factors to for stem cell production efficiency by over 50 times. Their first model on biological data and protein design. (OpenAI)

www.technologyreview.com/2025/01/17/1...

Happy New Year, blue-sci-peeps!

My piece in Annual Review of Biophysics on chromatin replication is now available online.

doi.org/10.1146/annu...

If you have paywall issues, try this link:

madhanilab.ucsf.edu/s/annurev-bi...