Statistical Physics of Cells and Genomes

Saddened to learn of the passing of Moselio "Elio" Schaechter—Distinguished Professor at Tufts, SDSU and UCSD—humanist and visionary leader in the fields of microbiology and scientific communication—mentor, friend, and inspiration to me and so many others

Small Things Considered
Big Things Achieved

Our group has a SEMM PhD opening in single-cell dynamics and cancer persistence:

www.semm.it/sites/defaul...

We seek outstanding candidates with cell biology expertise and practical experience in microscopy; physics&engineering backgrounds welcome.

Apply here
www.semm.it/education/ap...

The Hands-On Growth Laws Theory Cookbook This tutorial covers the emerging field of coarse-grained cellular growth modeling, and aims to bridge the gap between theoretical foundations and practical application. By adopting an original "cookb...

Our "Growth Laws Theory Cookbook" preprint is out! 👨‍🍳👩🏼‍🍳🧑‍🍳
arxiv.org/abs/2507.19194
*Learn our hands-on recipes and create your own!*

With Ciandrini and Micali labs
@micalilab.bsky.social

Thanks to Rossana Droghetti for coordinating the heavy lift.

Optimal Treatment for Drug-Induced Cancer Persisters Involves Release Periods and Intermediate Drug Doses Extending persistence modeling to drug-induced, dose-dependent cancer persistence reveals that strategic drug holidays and reduced doses can improve long-term treatment outcomes.

Our work on optimal treatment in presence of cancer persisters is out today in @prxlife.bsky.social 🎉

Alternated drug-release periods may be an advantage due to dose-dependent transition rates and slow death of persisters

journals.aps.org/prxlife/abst...

Postdoc_Evol_Genomics_Sorbonne.docx Postdoctoral position in Yeast Evolutionary Genomics Hosting unit Laboratory of Computational, Quantitative, and Synthetic Biology (CQSB). The CQSB is an interdisciplinary research unit within the ...

🚨 We're hiring! 🚨
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.

🔗 More info here:
docs.google.com/document/d/1...

Please repost!

#Postdoc #Genomics #Yeast #Polyploidy #Evolution

Excellent opportunity for Palestinian 🇵🇸 students looking to pursue Bachelor/Master degrees

- 97 full scholarships across 37 Italian universities
- Covers fees, housing, meals, health insurance
- €12,000/year average scholarship

Inquiry deadline is May 23

Links below, please circulate widely!

Great fun and great science at QMPE 2025 in Shenzhen! www.qmpe.net

It was fun and instructing to host you!

Just out on bioRxiv - spcg collab with Piel lab: growing mammalian cells use two independent systems — one controlling volume, one driving protein synthesis — to control macromolecular density.

Together, they restore dry mass density homeostasis.

www.biorxiv.org/content/10.1...

Spcg preprint with Bertotti lab and @litinice.bsky.social. It took >5y but proud to say it works—and we know why and how. μSeq infers mutation rates from deep sequencing of single clonal expansions, >10x faster than MALs. Validated in cancer organoids and in yeast.

tinyurl.com/4jmk3tkh

New spcg preprint with Bokinsky lab (Milan Lacassin), by Andrea Ripamonti. We model the competition for transcriptional resources, and explain new data on E. coli’s second messengers ppGpp & cAMP reshaping gene expression globally.

www.biorxiv.org/content/10.1...

Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli - Nature Communications Current theories of bacterial growth physiology often lack mechanistic detail. Here, Droghetti et al. present a theoretical framework that includes sensing and regulation of protein synthesis at the m...

New spcg&collabs paper, by Rossana Droghetti: Model for E. coli dynamical balance of amino acid pools, ppGpp signaling, and ribosome allocation to regulate growth, explaining observed damped oscillatory feedback in response to nutrient shifts 🧫 #GrowthLaws

www.nature.com/articles/s41...

We just landed from X... almost ready to post about a lot of our recent news!

See here for our old posts x.com/SPCGgroup