Tom Ambrosi

Longeveron's Laromestrocel for Frailty: Breaking Down Cell Stem Cell Data & Problematic Nature Coverage - The Niche Biologist provides perspectives on new MSC frailty study published in Cell Stem Cell from Longeveron and provides background.

Longeveron's Laromestrocel for Frailty: journal club on @cp-cellstemcell.bsky.social pub Data & Problematic Nature news Coverage ipscell.com/2026/03/long... #stemcells #stemcell @caulfieldtim.bsky.social

A Discovery Enabled by Federal Funding: Scientists Identify Hormones That May Offer Hope for Osteoporosis and Osteoarthritis Patients - Office of Research Osteoarthritis and osteoporosis, two common degenerative musculoskeletal diseases affecting roughly 33 million adults in the United States, leave millions coping with fragile bones, fractures, and wor...

Enabled by federal funding, scientists @ucdavishealth.bsky.social and @ucsfhealth.bsky.social have identified a molecule that could open the door to treatments for conditions that weaken both bone and cartilage. Learn more.
bit.ly/4l0YnQW
#FromLabsToLives

Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis - Nature Communications Glucocorticoid (GC) induced osteoporosis (GIOP) remains a significant clinical problem. Here, the authors find that GCs disrupt skeletal stem cell–endothelial crosstalk via Basigin that can be targete...

Some good lab news among all the turmoil! Excited about this new publication in collab with Dr. Nancy Lane. Great effort by graduate student Dave & postdoc Kun! Looking forward to presenting this & more at @asbmr.bsky.social meet next month! @ucdavishealth.bsky.social www.nature.com/articles/s41...

Stronger bones? A @cp-cellstemcell.bsky.social study by @drambrosi.bsky.social of @ucdavis.bsky.social, funded in part by @wutsaialliance.bsky.social, shed light on how skeletal stem cells change with age and how to boost their fracture-healing abilities. humanperformancealliance.org/news/skeleta...

4/n

Grateful during these uncertain times to have had the support to continue Chuck's legacy. @ucdavis.bsky.social, @ucsandiego.bsky.social, Stanford University, @czbiohub.bsky.social www.cell.com/cell-stem-ce...

Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites Ambrosi and colleagues profile human skeletal stem cells (hSSCs) across ten fetal skeletal sites and from patients throughout adulthood, identifying, mapping, and functionally testing four distinct hS...

I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

We do have a “SSC diversity” grant🫣

Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration Abstract. In our aging society, the degeneration of the musculoskeletal system and adjacent tissues is a growing orthopedic concern. As bones age, they bec

Congratulations to Dr. Ambrosi and grad student Kelly Weldon of @UCDavisHealth for this important manuscript! 👏🏻👏🏻👏🏻
Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration academic.oup.com/stmcls/artic...

Just a reminder that Germany was the center of scientific progress until the Nazis suppressed, drove away, or killed all the non-Nazi scientists.

8/ BOTTOM LINE: NIH BUDGET CUTS WILL MARKEDLY HURT EVERY STATE IN THIS UNION. AND RED ONES RELATIVELY MORE. REPUBLICAN & DEMOCRATIC REPS IN EACH STATE SHOULD BE LASER FOCUSED ON NOT PASSING REFORMS OR ALLOWING EXECUTIVE ORDERS TO FLY THAT HURT REVENUE GENERATION & JOB PROSPECTS. THIS HURTS PEOPLE!

Check the comments for links to opportunities!

Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis Glucocorticoid (GC) induced osteoporosis (GIOP) and osteonecrosis remain a significant health issue with few approved therapies that can treat the bone loss and dysfunction of skeletal vasculature. Th...

New and first pre-print of the lab. Fun project with Nancy Lane @ucdavis.bsky.social. Feedback welcome. www.biorxiv.org/content/10.1...

Getting started on this platform by sharing this small year in review I wrote.
rdcu.be/d2U69

A maternal brain hormone that builds bone - Nature A brain-derived hormone, CCN3, is newly identified to have a role as an osteoanabolic factor to build bone in lactating females and in the viability of offspring.

Here is an excellent publication with some of the important work in brain-bone signaling from @drambrosi.bsky.social and team.

www.nature.com/articles/s41...