It was a fantastic trip and a pleasure talking with the Pfizer team 😄 One highlight was discovering they’ve built a web GUI for ROCKET to make it more accessible—I’m thrilled (and even a bit surprised) to see how our tool helping people solve real-world problems.
New OpenFold3 preview out! (OF3p2)
It closes the gap to AlphaFold3 for most modalities.
Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9
After an Amtrak coding session with @minhuanli.bsky.social, ROCKET team is back at @rs-station.bsky.social HQ! Thank you to Pfizer for welcoming us in Groton and to everyone who attended our seminar online. Exciting work ahead to continue exploring frontiers in structure determination. Back to it 🚀
Take a look at our March issue: journals.iucr.org/d/issues/202...
On the cover: the response of two paradigmatic metalloproteins of different types, one iron-containing and one copper-containing, to X-ray-induced metal reduction at cryo- and room temperature journals.iucr.org/d/issues/202...
The @thecimr.bsky.social and MRC Mitochondrial Biology Unit are celebrating "Rare Research Day" TODAY!
By creating factsheets on how their work contributes to greater understanding and potential treatments.
#RareDiseaseDay #ShareYourColours #RareDiseaseDay2026 #UniversityofCambridge
I find Airlie’s composite self rotation representation much easier to interpret. Check it out!
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
Finally comms from UKRI - on a Sunday evening. No mention of the hundreds of ECRs who will see their careers ended by these decisions and notably no explanation for MRC retrospectively applying cuts and wasting all the work that went into writing, reviewing and scoring applications - £millions
Missed it, thanks for pointing it out!
My hero!!! An amazing scientist and a wonderful person!
Has the MRC research funding ‘pause’ been covered by any major news network?
It feels like it should be a major news story
We have a fantastic opportunity for a PhD studentship in collaboration with @jesuscollegecam.bsky.social and Cambridge Children’s Research Institute, part of the new Cambridge Children’s Hospital. Closing date 20th Feb; all the details here: www.cimr.cam.ac.uk/postgraduate...
She continues to be a lively presence at structural biology meetings. And for my money has the deepest, most intuitive understanding of protein geometry. A treasure.
As someone who works directly with her in Phenix, I can tell you she is still one of the most focused and dedicated people I know!
By the way, this is by the @alisiafadini.bsky.social behind ROCKET!
New Title Alert: meteor- a tool for computing crystallographic difference maps that specializes in robust identification of weak signals from minor populations such as bound ligands or time-resolved experimental changes.
Learn more here: buff.ly/bgJYF9N
#SBGrid #SBGridSoftware #StructuralBiology
Now available: the Proceedings of the 2024 @ccpem.bsky.social em Spring Symposium, including a review of the first ten years of the Symposium: journals.iucr.org/special_issues/2025/CCPEM2024/
View all of the Proceedings at journals.iucr.org/d/services/ccpem
Hope to see you there!
Logos for IUCr2026 and Phenix
#IUCr2026 Pre-Congress Workshop: Structure Solution with Phenix
Offers lectures and tutorials on using Phenix for automated macromolecular structure determination and validation from xtal and cryoEM data, integrating predicted models like AlphaFold
event.fourwaves.com/...
There are a lot of ways to say in words how confident you are about something happening, so it’s good to see how consistent you are with yourself and others! (Turns out I’m not very consistent in how I rank near-synonyms.)
Our January issue is out: journals.iucr.org/d/issues/202...
The cover highlights a data survey of the PDB and CSD for macromolecular and ligand structures that have been determined at elevated temperatures. Read more at doi.org/10.1107/S205...
Check our new preprint smoothing rugged Cryo-EM landscapes: shorturl.at/gYs9U
We tackle practical hurdles of Optimal Transport (OT) loss—differentiability, cost & noise sensitivity—make it a feasible inference workhorse.
W/ G. Woollard, D. Herreros, @pilarcossio.bsky.social, K. Dao Duc 🧵👇 (1/9)
This is a classic of the genre!
RE: https://fediscience.org/@Guillawme/111534984107819771
Something really cool happened to me this year!
@HRBridges re-processed a #cryoEM dataset from some previous work of mine and colleagues (publicly available as EMPIAR-10739; see quoted post below for a summary of this work). She […]
I got one even though I don’t have a current NIH grant. I’ve certainly been asked to update things before, though maybe not with this wording.
From Sameer Velankar & colleagues in @narjournal.bsky.social #NARDatabaseIssue | PDBe: enhanced structural data exploration to facilitate discovery | #Bioinformatics #Database #OpenScience #Proteomics #PDB 🧬 🖥️🧪🔓
⬇️
academic.oup.com/nar/advance-...
Wow, that’s exciting! Looking forward to seeing what you get up to!
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
IUCr 2026 Grants
Apply for #IUCr2026 travel grants
Funds are available to support students, early-career researchers, and participants from under-resourced institutions and/or developing countries.
Details at event.fourwaves.com/...
