Wojciech Pokrzywa

CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub The nucleolus, classically dedicated to ribosome biogenesis, also acts as a stress-responsive proteostasis hub. During heat shock, misfolded proteins accumulate in its granular component (GC), but whe...

Preprint alert! 🚨
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...

We have an open postdoc position! Join us to study how ubiquitin ligases and non-canonical modifications regulate protein stability.
🗓️Apply by: 10.03.2025
🔬Start: 01.08.2025 | Warsaw
💰Salary: ~8300 PLN gross
More & apply: tinyurl.com/pokrzywalab-...
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IIMCB

We're hiring! 🚨 Looking for a talented MSc graduate to join our team to work on bacteriophages, and bacterial translation using cutting-edge techniques like transcriptomics, proteomics, and single-molecule microscopy. Apply today: bit.ly/3PQjR46

We have identified a novel MAPK1 variant linked to a unique psychiatric disorder with early-onset dementia and demonstrated its role in age-dependent neurodegeneration. Thanks to all collaborators involved!
www.researchsquare.com/article/rs-5...

DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies In an era of rapid scientific advancement, the need for engaging educational tools is critical. DEGRADATOR, a 2D computer game, bridges this gap by immersing players in the ubiquitin-proteasome system...

Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @acspublications.bsky.social
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...