Not all bacteria are beneficial in every context.
We found that enriching Drosophila with a commensal bacterium reduces tolerance to viral infection. The effect was virus-specific and occurred without changes in viral load, immune gene expression or intestinal damage.
rdcu.be/eZ4Sd
In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals.
#Aging #Infection #MicroSky #Virology
📖 shorturl.at/OeYVp
✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social
@salehlabparis.bsky.social @pasteur.fr
What a day! Another one flies the nest with a brilliant PhD defense. Congratulations Doctor @castellosanjuan.bsky.social ! I am so proud of you!!! #PILife #ProudMentor #PhD
Ha passat un any.
Temps insuficient per a un dol tan gran.
Hui és dia de fer memòria pels que ja no estan
i de cuidar a totes les víctimes.
Però cal recordar que s'ha de continuar lluitant,
perquè encara no s'han atés les nostres demandes:
VERITAT.
JUSTÍCIA.
REPARACIÓ.
4-Me working with @rubengonzalez.bsky.social. Text caption "Got to supervise my own post-doc (Rubén)"
2-A screenshot of my phone gallery showing all the sheets of manually recorded data. Text caption "This is a Snapshot of what my life has been"
3-The fly incubator with fly drawings all around, all customized. Text caption "Mum let me decorate my room"
I will think about this next time! Sorry I missed it here. Here is the description of the pics:
1- A cartoon of a sick Drosophila melanogaster, wearing a mask, and surrounded by four viruses of different colours (the viruses of the study)
(5/5)
Thanks to all members of the @salehlabparis.bsky.social for support and teamwork; couldn't have done it without you 🫶
Thanks to @pasteur.fr for hosting me during my PhD journey😄👨🔬
The corrected proofs are out! Read the full article at @plosbiology.org : plos.io/4olpuXmm
Having shared that...
(4/5)
We found that:
*Persistence reduces fly survival
*Hosts trade reproduction for immunity
*Persistently infected flies have impaired movement and altered sleep, but keep circadian rhythm
*Different viruses trigger distinct transcriptional responses
*And more!
(3/5)
But first, I wanna share some sneak peeks of how this work has come to be, how I made the lab home, and the bonding that comes with working closely:
(2/5)
In our latest work, we established persistent viral infections to examine their impact on this model organism.
We followed survival and other life history traits, and we also performed a transcriptomic analysis over time… (The data is available for you to play with it! 💻🧬🪰)
I'm so excited to share this with all of you!
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
Cartoon illustration depicting a sick Drosophila melanogaster surrounded by different viruses, symbolizing the impact of persistent viral infections on the model organism. Image credit Rubén González.
Persistent viral #infections in #insects are not as harmless as once believed. @salehlabparis.bsky.social &co show how such infections in #FruitFlies alter survival, reproduction, behavior & gene expression, revealing the hidden costs of #viral persistence @plosbiology.org 🧪 plos.io/4olpuXm
