My personal rule is: always be kind, understanding, and willing to listen to your female colleagues. Whatever they have achieved, in most cases it is more than deserved and they have something to teach you!
Great article by @NaturePortfolio
www.nature.com/articles/d41...
www.linkedin.com/posts/activi...
@science.org @nature.com @cellpress.bsky.social
Sometimes one is enough!
#neurons #tau
🧠 Congrats Diletta Cavezza presenting at the:
@hippocampus spring meeting (lnkd.in/di4KNgYgin) in Verona!
"#Sex-dependent engagement of reuniens-hippocampal pathway during incidental encoding"
#Consiglio Nazionale delle Ricerche - IBBC
#Mnesys
Tigem
#Fondazione Telethon
Great meeting
Great!
⚖️ Takeaway?
The good and the bad of dopamine all depend on the dose — and the circuit engaged.
🧠 A special thank to Maria De Risi, brilliant, talented, and extraordinarily productive scientist and to Diletta Cavezza #Giulia Torromino, Anita Capalbo Xabier Bujanda Cundin
🧪 Our #phosphoproteomic data reveal that low vs. high doses of D1 agonist trigger completely different signaling profiles.
It’s as if we were administering two entirely different drugs — astonishing!
🧬 #PKA has long been considered essential for hippocampus-dependent long-term memory, but deleterious for #WM.
We demonstrate that PKA activation in the striatum is beneficial for working memory capacity. This calls for targeted, region-specific PKA modulators — intelligent PKA agents.
🧠💡 Why does this matter?
✅ We confirm that low doses improve memory in a schizophrenia mouse model, using the same dose range previously applied by #PatriciaGoldman-Rakic in monkeys (unlike the much higher doses in recent rodent studies).
✔️ High-dose recruits PKA in the cortex — again, not novel — but:
Cortical PKA activation recruits parvalbumin interneurons in the #striatum, shutting down the striatum, thus impairing memory.
Thus: a fronto-striatal circuit mechanism for the dose-dependent effects of DA drugs on memory.
This inverted-U dose-response curve is well-known in the literature — nothing new here.
🔍 So, what’s new?
✔️ Low-dose D1 stimulation expands MC via #PKA activation in the striatum.
We show that striatal PKA activation is both necessary and sufficient to enhance memory capacity.
🧠💥 For #Dopamine (DA) & #Memory lovers!
📢 New paper!! we show that memory capacity (MC) in mice can be expanded from 6 to 8 objects using low doses of a D1 receptor agonist. Higher doses? Paradoxically, they reduce MC.
#Tigem
#Consiglio Nazionale delle Ricerche
lnkd.in/d9skfGeb
Looking for an exciting fellowship in AI & Neuro, with competitive salary (~£100k)? We got a new position in the lab at Oxford, working with @somnirons.bsky.social and me! 🧪
Our project: encode.pillar.vc/projects/beh...
General info: encode.pillar.vc
#compneuro #neuroai #neuroscience #sciencejobs
It took so much time to get here, we cannot give up!
Young researchers mobilize to protest Trump administration’s science policies www.statnews.com/2025/02/13/r... via @statnews.com
@jpflores.bsky.social @samschuelstein.bsky.social @emmalovesscience.bsky.social @leslie-bern.bsky.social @standupforscience.bsky.social
Grazie Francesco ❤️
📢 💥 We are ecstatic to announce that another one of our studies on Sanfilippo disease has been published in #MolecularPsychiatry.
#Sanfilippo is a rare genetic lysosomal storage disorder (#LSD) that leads to #neurodegeneration and #dementia.
www.nature.com/articles/s41...
Hard time for #science @scinews.bsky.social
www.science.org/content/arti...
Non c'è mai fine al peggio!
Remembering Eleanor Maguire, ‘trailblazer’ of human memory
www.thetransmitter.org/memory/remem...
#neuroscience
Hi Camille, we use rat 226 017. You can send an email to diletta.cavezza@ibbc.cnr.it for details
Super! Congrats!
Mhh we use it, without problems. What is the problem?
Thank Bita @bita137.bsky.social for this post. It gives us an idea of how much scientists need training on mentoring and evaluation, to understand our limitations and biases.
Striatal stimulation enhances cognitive control and evidence processing in rodents and humans
www.science.org/doi/10.1126/...
#neuroscience
Exciting news from the lab! In collaboration with our #EU-Nanobrigth partners, we’ve developed and tested a new probe for vibrational fiber photometry, enabling minimally invasive Raman spectroscopy deep into the 🧠. www.nature.com/articles/s41... @naturemethods.bsky.social
Anno Domini 2024
👉Nel mondo sono attivi 56 conflitti
👉A #Gaza sono stati uccisi oltre 3.000 bambini
👉In Italia 4,5 milioni di persone rinunciano alle cure
👉A Milano 1 km di poveri sono in fila per un pasto
Poi è stato anche un "anno difficile" per #ChiaraFerragni
Oggi il Servizio Sanitario Nazionale compie 46 anni.
La sua “mamma” sarebbe molto indignata per l’ignobile tradimento dei princìpi fondanti da lei voluti
#SalviamoSSN
