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Katy Brown

@thekatybrown

Postdoc in computational genomics studying RNA viruses at Cambridge. She/Her https://orcid.org/0000-0002-8400-6922

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19.12.2023
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Latest posts by Katy Brown @thekatybrown

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I cherish this mug so much that I don't even use it for liquids..
And it's from the 1993 my beloved paper by Dolja and Koonin. I will forever be grateful for @thekatybrown.bsky.social for such a thoughtful gift! :)

Their work was also what got me into virology without any hesitation:)

12.02.2026 19:11 πŸ‘ 11 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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🧬 Data scientists and enablers with experience in UK biomedical research: Your experience matters! MRC-funded research to tackle isolation & career barriers in biomedical data science roles.

app.onlinesurveys.jisc.ac.uk/s/oxford/bio...
πŸ“… Closes: 6/3/26
Β£50 Prize draw
Contact: integrate@imm.ox.ac.uk

15.01.2026 12:04 πŸ‘ 6 πŸ” 8 πŸ’¬ 0 πŸ“Œ 2
Expression of Retroviruses in Guinea Pig Lymphomas Retroviruses commonly cause neoplasia in many species but have not been described in guinea pigs. While historical evidence exists for the presence of an active retrovirus in domestic guinea pigs ( Cavia porcella), there has been no description of the sequence of these viruses or their role in disease in guinea pigs. This paper uses genome mining of the published domestic and wild ( Cavia aperea) guinea pig genomes for retroviral sequences to identify the gamma and beta-retroviral complement of the Cavia genome, describing eight groups of viruses with evidence of recombination between virus groups. The most intact group, gamma-like retroviruses related to HERV-T (integration estimates of 855,000 to 3.8 million years ago), has five near full length loci that are likely capable of active infection. RNA-Scope In-situ Hybridisation of archived formalin-fixed, paraffin embedded (FFPE) guinea pig lymphoma sections with a probe for one of these loci demonstrated viral RNA expression in lymphoma tissue, strengthening the case for a role of these viruses in the high incidence of leukaemia and lymphoma in this species. ### Competing Interest Statement The authors have declared no competing interest. University of Nottingham, https://ror.org/01ee9ar58

I have a new preprint! www.biorxiv.org/content/10.6... I found this endogenous retrovirus as a PhD student with @rtarlinton.bsky.social back in 2012 - a mere 14 years later we've written it up! This ERV is expressed in guinea pig lymphomas and might explain their high rate of lymphoma/leukemia. πŸ’»πŸ§ͺ

20.01.2026 14:27 πŸ‘ 11 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

It would be interesting to look! But it’s hard to find them.

17.12.2025 16:54 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Perfect summary!

17.12.2025 16:53 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

also the post at the ToL slack was captioned

barger badger badger badger
virus virus
AAAAAAAHHH sponge sponge it's a sponge

17.12.2025 16:39 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Thank you! This is amazing!

17.12.2025 16:35 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
comic doodle of a speaker in greys blacks and whites, with a red orange background, the topics include RNA viruses, a badger, and a sponge with viral spots.

comic doodle of a speaker in greys blacks and whites, with a red orange background, the topics include RNA viruses, a badger, and a sponge with viral spots.

really nice talk by @thekatybrown.bsky.social on fishing for viruses in our Darwin Tree of Life @sangerinstitute.bsky.social datasets 🎣🦠

#SciArt #sketchnote

17.12.2025 14:24 πŸ‘ 22 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0

Proud to have been a part of this! www.cell.com/cell/fulltex...

17.11.2025 10:41 πŸ‘ 7 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

#bioinformatics #rnavirus #virology

28.10.2025 13:27 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

+ all kinds of EVEs in arthropods! I also found a bunch of viral pathogens mislabelled as bacterial and explored "near miss" proteins - with probably coincidental similarity to RdRp. 5/5

28.10.2025 13:27 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I love EVEs so I spent time exploring and found orbivirus like EVEs in nematodes which pre-date species divergence and with a likely infectious counterpart, loads of diverse mitovirus-like regions in plants, and the first EVEs in the Perkinozoa phylum of protists 4/5

28.10.2025 13:27 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Initially I wanted to explore how complicated it is to use database proteins as a negative control when looking for viruses because so many are unlabelled viral sequences. But then I unexpectedly found hundreds of RdRp-like endogenous viral elements 3/5

28.10.2025 13:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I dug into proteins labelled as e.g. "unchacterised protein", "hypothetical protein" without any named function from any species in the NCBI protein and UniProt databases to find proteins related to RdRp 2/5

28.10.2025 13:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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My paper is out! Uncovering hundreds of exogenous and endogenous RNA viral RdRp sequences amongst uncharacterised sequences in public protein databases. doi.org/10.1093/ve/v... πŸ’»πŸ§¬ 1/5 🧡

28.10.2025 13:27 πŸ‘ 34 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0
Title screen for "Jeff Jet: Adventure on the InfoHighway".

Title screen for "Jeff Jet: Adventure on the InfoHighway".

Screenshot from "Jeff Jet: Adventure on the InfoHighway". In front of a green room that seems to be built out of giant circuit board pieces, there are close-up pictures of Jeff Jet and an NPC wearing glasses and a red sweater. A line of dialog is visible between them: "Good day to you!".

Screenshot from "Jeff Jet: Adventure on the InfoHighway". In front of a green room that seems to be built out of giant circuit board pieces, there are close-up pictures of Jeff Jet and an NPC wearing glasses and a red sweater. A line of dialog is visible between them: "Good day to you!".

Screenshot from "Jeff Jet: Adventure on the InfoHighway". The two main characters, Jeff and Donna, are standing near a road tunnel with a closed barrier gate in front of it and a guard standing by. There is a large truck loaded with gigantic ones and zeroes. The mouse cursor is hovering over these ones and zeroes, and the word "Bits" appears next to it.

Screenshot from "Jeff Jet: Adventure on the InfoHighway". The two main characters, Jeff and Donna, are standing near a road tunnel with a closed barrier gate in front of it and a guard standing by. There is a large truck loaded with gigantic ones and zeroes. The mouse cursor is hovering over these ones and zeroes, and the word "Bits" appears next to it.

Screenshot from "Jeff Jet: Adventure on the InfoHighway". One of the main characters, Donna, stands in the middle of a large desert tent with visible patches and holes. A small office area has been set up behind her, with a woman sitting at a desk with a computer on it. There is an empty chair with a green coat lying on it in the foreground facing the desk. At the bottom of the screen, there is a row of inventory items. The mouse cursor is over one of them, a red and green magnet, with the word "Magnet" shown next to it.

Screenshot from "Jeff Jet: Adventure on the InfoHighway". One of the main characters, Donna, stands in the middle of a large desert tent with visible patches and holes. A small office area has been set up behind her, with a woman sitting at a desk with a computer on it. There is an empty chair with a green coat lying on it in the foreground facing the desk. At the bottom of the screen, there is a row of inventory items. The mouse cursor is over one of them, a red and green magnet, with the word "Magnet" shown next to it.

I translated "Jeff Jet: Abenteuer InfoHighway" as "Jeff Jet: Adventure on the InfoHighway" archive.org/details/jeff... - a German promotional adventure game for Hewlett Packard from 1995.

22.09.2025 16:47 πŸ‘ 15 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0

Come to the BOKR session at 2:20 and see Charlotte Tumescheit @schnamo.bsky.social give a super interesting talk about improving prediction of molecular properties by incorporating ontologies. #ISMBECCB2025

23.07.2025 13:30 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Someone needs to implement an LLM to help select which talks to go to at #ISMBECCB2025

23.07.2025 13:22 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Come and see me in the ice rink if you want to plot phylogenies in matplotlib! Poster 206. GitHub.com/KatyBrown/plot_phylo #ISMBECCB2025

22.07.2025 09:13 πŸ‘ 8 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

You ring the doorbell on Oncology, just show any card, they won't check, then go down two floors in the lift, around the corner and then up one floor, once you get outside climb over the fence, scrabble up the verge, sign in as a visitor and you're there.

21.07.2025 20:38 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

It's the same in the UK. They specialise in roads which look like they link together but there's a huge fence or mysterious ditch blocking the way, or they've joined two buildings across the gap but not added a door to let people through.

21.07.2025 20:32 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
ISMBECCB_2025_All_Detailed_Schedule.csv

I reformatted the #ISMBECCB2025 schedule a bit - in case anyone else wants to use it this way - ordered by day and start time:

csv: drive.google.com/file/d/1JyhT...

xlsx:
docs.google.com/spreadsheets...

21.07.2025 08:05 πŸ‘ 2 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Thank you! This is amazing.

21.07.2025 08:09 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Excited for the ISMB/ECCB conference! I have two posters A520 today about an endogenous and exogenous virus I found in nematodes - and B206 tomorrow about my tool plot_phylo for drawing phylogenies in matplotlib. #ISMBECCB2025

21.07.2025 08:04 πŸ‘ 9 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

And the same colour!

09.07.2025 11:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Is it so much to ask for all my bullet points to be 1. the same size and 2. in a straight line?

09.07.2025 11:07 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

I could do my job in half the time if we just picked a column delimiter and stuck with it and then no-one can use that symbol for anything else. Let's not use * to both delimit columns and represent a stop codon, or use a random number of spaces, or put "_" in our sequence IDs. πŸ–₯️πŸ§ͺ

27.06.2025 13:58 πŸ‘ 4 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
Too poor to science: How wealth determines who succeeds in STEM From student to researcher, a career in science can come with a high price tag. This Perspective explores how persistent financial barriers limit who can succeed in science, revealing how wealth shape...

From student to researcher, a #career in #science can come with a high price tag. @drcraigmc.bsky.social explores how wealth shapes opportunity in #STEM and proposes structural changes to support #equity and inclusion. πŸ§ͺ
plos.io/4edGlY4

24.06.2025 09:41 πŸ‘ 28 πŸ” 13 πŸ’¬ 0 πŸ“Œ 0

There should be a ban on broadcasters using footage of β€œanonymous” (heads cropped out) larger people - who could nevertheless recognise themselves based on knowing their own bodies and clothes - to illustrate stories about obesity, fat or weight loss

23.06.2025 10:56 πŸ‘ 156 πŸ” 27 πŸ’¬ 11 πŸ“Œ 4

Are you interested in using AI to decode RNA? Have a look at this brilliant new review from my friend @schnamo.bsky.social and her colleagues.

23.06.2025 09:17 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0