Tomas Dolezal

How does nutrient-responsive #mTORC1 sense the key amino acid #glutamine?
Gianluca Figlia, Aurelio Teleman et al @telemanlab.bsky.social identify a combination of GCN2-dependent processes triggered by secondary depletion of asparagine in glutamine-starved cells
www.embopress.org/doi/full/10....

Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila Hirooka et al. show that Draper-mediated phagocytosis induces Upd3 in macrophages, amplifying tumor-derived Upds and activating JAK/STAT signaling, which promotes RasV12/scrib tumor growth in Drosophi...

Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila: Current Biology www.cell.com/current-biol...

An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan Author summary Mutations in the invertebrate insulin/IGF signaling system robustly extend lifespan. Yet these interventions often cause insulin resistance, reduce growth, and impair fertility. In cont...

An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan
journals.plos.org/plosgenetics...

Online now - the Spotlight " #SAMcycle and #adenosine at the heart of immune conversations" from Tina Mukherjee and colleagues.

#macrophages #infection #immunometabolism #SAMtransmethylation

authors.elsevier.com/a/1lHcd3S6Gf...

Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin, and juvenile hormone | PNAS Dietary restriction (DR) slows aging in many animals, while in some cases, the sensory signals from diet alone are sufficient to retard or accelera...

Chen, J., Nouzova, M., Noriega, F. G., Tatar, M. (2024). Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormone. Proc Natl Acad Sci www.pnas.org/doi/abs/10.1...

Recent study by the team of Tomáš Doležal @tomasdolezal.bsky.social on the role of adenosin molecule in immune response was highlighted by the Science journal (www.science.org/doi/10.1126/...).

Julius Lukeš (@czechacademy.bsky.social) is the only living scientist from the Czech Republic to become a member of National Academy of Sciences (@nasonline.org) a prestigious US institution. And he does it his own way. Congratulations!
(Photo courtesy - Biologické centrum AVČR)

How does cancer affect motivation? Inflammatory cytokines hijack a brain circuit to cause apathy in cancer

In a new Science study, researchers describe a neural circuit underlying cachexia-related apathy in a mouse model of cancer.

Learn more: scim.ag/4iIQFbq #SciencePerspective

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice. Liu, Dantas, Ferrer, Miao T, Qadiri, Liu, Comjean , Davidson, Perrier, Ahmed, Hu, Goncalves, Janowitz, Perrimon. Nat Metab. 2025 doi: 10.1038/s42255-025-01265-2. PMID: 40275022

When the fruit fly larva looses, an alien emerges. (parasitoid wasp Leptopilina boulardi, essential for our immunometabolic studies) #parasitoid #Drosophila

We are excited to announce the opening of registrations for the upcoming #EDRC2025 conference (25th-28th September 2025) in Alicante to showcase the latest advances in #Drosophila biology and technology edrc2025alicante.com

David Bilder @bilderlab.bsky.social is one of #EDRC2025 plenary speakers. He is full professor @ucberkeleyofficial.bsky.social where he runs a research lab focusing on the mechanisms that govern epithelial polarity, cell shape, and tissue morphogenesis using #Drosophila of course! 🪰🧪

Energizing immune cells Experiments in fruit flies reveal a mechanism that immune cells can use to control the availability of nutrients when fighting infections.

Check this eLife Digest - elifesciences.org/digests/1050... of our new paper in eLife (@elife.bsky.social) if you want to learn how cells can use adenosine as a sensor of a balance between their activities and nutrient supply.

Have you ever wondered how a cell can measure its current activity? And if it is a privileged cell within an organism, how does it demand an adequate supply of nutrients from its environment? Check out our new article in eLife …

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.

In @elife.bsky.social: SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response doi.org/10.7554/eLif...

Scientists as political advocates Science, both teaching and doing, is under attack. The recent US presidential election of a person and platform with anti-science bias exemplifies this. The study of climate processes and patterns and...

"Science, both teaching and doing, is under attack."

Speak up. Act. And in the words of Dan Savage, keep dancing.

www.science.org/doi/10.1126/...