Jean-Ehrland RICCI

Check how their study reveals a novel HPV16 E7-APC2-SPIN4 axis as a key driver of cervical cancer, where APC2 unexpectedly functions as an oncogene by activating the Wnt/β-catenin signaling to promote tumorigenesis and CSC properties.

“Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer”

🔵 Shizhou Yang ‘s latest research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how the authors demonstrated that USP21 physically interacts with G3BP1, enhancing its protein stability and thereby promoting ESCC progression through activation of the Wnt/β-catenin signaling pathway.

“USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling”

🔵 Interesting research led by Xiaogang Zhao has been featured in #Oncogenesis.

▶️ Read the full article here: www.nature.com/articles/s41...

Check how their findings uncover a muscle-induced pseudo-hypoxic program that restricts cancer cell proliferation. Therefore, they highlight the need for caution in targeting hypoxia in anti-metastatic therapies, as such it could weaken skeletal muscle’s natural defense against tumor colonization.

“Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell’s anti-proliferative effect on cancer cells”

🔵 Jerome Ruzzin‘s latest research is available to read in #Oncogenesis.

▶️ Read the full article here: www.nature.com/articles/s41...

Check how this study shows that TH1579 has the potential to improve ICI treatment by modulating immune checkpoint-related proteins and pathways.

“Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway”

🔵 Interesting research led by Thomas Helleday has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study suggests FABP4-mediated FA metabolism as a therapeutic target to counteract T cell senescence in adipocyte-rich TME, providing a novel immunotherapeutic strategy for Ovarian Cancer.

“Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer”

🔵 Weimin Deng ‘s research is now available to read in #Oncogenesis.

▶️ Read the full article here: www.nature.com/articles/s41...

Check how their study suggests that PHF2 acts as a candidate epigenetic tumour suppressor in HCC patients through the downregulation of SRXN1independent of Nrf2.

“The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1”

🔵 Edward Kai-Hua Chow‘s latest research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their results suggest that USP32 activates the RAF/MEK/ERK signaling pathway, which in turn promotes NSCLC cell proliferation, migration, and EMT progression through deubiquitination and stabilization of BAG3.

“USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway”

🔵 Interesting research led by Chunyan Liu has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their study presents a novel model for understanding how genetic alterations in cytoskeletal genes can directly contribute to cancer development and drive cancer evolution and shows it can lead to the reactivation of cancer dormancy and tumour spread.

“Cytoskeleton reorganization induced by a novel K6-K14 keratin fusion promotes cancer stemness and cellular plasticity via cGAS-STING selection”

🔵 Jim Jinn-Chyuan Sheu‘s latest research is now available to read in #Oncogenesis.

▶️ Read the full article here: www.nature.com/articles/s41...

As an advocate for Oncogenesis, I regularly encourage colleagues to submit their latest studies to the journal and aim to promote Oncogenesis broadly through cancer research networks.

We are very lucky to have him on the team at Oncogenesis! 🤝

I have served as Associate Editor of Oncogenesis for over 5 years and in this role, I continually strive to ensure we publish high quality research and new insights in these areas.

🧬 Meet One of Our Associate Editor: Philip Gregory

As head of the Gene Regulation in Cancer laboratory at the Centre for Cancer Biology in Adelaide, my research focusses on understanding how epigenetic changes regulate cancer cell plasticity and contribute to metastasis and treatment resistance.

Check how their findings demonstrate that Rab37 governs macrophage phenotype and function by orchestrating OPN/STAT3 signalling, thereby reinforcing an immunosuppressive TME and promoting lung cancer progression.

“Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression”

🔵 Yi-Ching Wang‘s latest research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their study revealed a potential mechanism by which DAB2IP can act as a scaffold to promote the interaction between HIF-1α and STUB1, thus inducing HIF-1α ubiquitylation degradation and inhibiting glucose uptake in breast cancer cells under hypoxic conditions.

“DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer”

🔵 Interesting research led by Jie Shen has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their findings uncover a novel PRAS40/PGK1 regulatory axis that promotes CRC stemness and tumorigenesis through enhanced glycolysis, suggesting potential therapeutic strategies targeting this axis for CRC treatment.

“PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation”

🔵Lin Huang‘s latest research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Congrats !!! Well deserved.

Check how demonstrated that combination therapies targeting PKC and PKC-independent signalling nodes, including PI3K/AKT activity, are required to improve responses in patients with metastatic uveal melanoma.

“PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma”

🔵 Outstanding research led by Helen Rizos has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this work provides evidence that targeting mitochondrial PE synthesis is sufficient to disrupt mitochondrial metabolism and promote oxidative stress, which may be a metabolic vulnerability that can be targeted to slow HCC progression.

“Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma”

🔵 Timothy D. Heden‘s latest and impressive research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...